Effects of nutritional status on exercise performance in advanced cystic fibrosis.

Abstract:

:Initial evaluation of 22 patients with cystic fibrosis (CF) on entry into a trial of home oxygen therapy was used to elucidate the possible effects of poor nutritional status on exercise performance in CF. The patients had advanced lung disease (mean FEV1, 36 percent predicted) and all had a stable resting PaO2 less than or equal to 65 mm Hg. Nutritional status was determined by calculating weight as a percentage of ideal for height (Wt/Ht) for each subject. Exercise testing consisted of a progressive exercise test on a cycle ergometer to measure maximum work capacity (Wmax), and a steady state test at 50 percent of baseline Wmax. During the steady state test, cardiac output (Q) and stroke volume (SV) were computed by the indirect Fick (CO2) method. Wmax, SV, Q and lung function results are expressed as percent predicted. Mean (+/- SD) Wmax was 58 +/- 15 percent predicted. Wmax correlated with both FEV1 and Wt/Ht, but FEV1 and Wt/Ht were not related. During steady state exercise, 12 of 22 patients had a SV less than 80 percent predicted. SV correlated with Wt/Ht, but not with lung function. Thirteen of the 22 patients had a Wt/Ht less than or equal to 90 percent and were considered malnourished. When compared with the well-nourished patients (Wt/Ht greater than 90%), these malnourished subjects had significantly lower mean values for Wmax%, SV% and Q% predicted, but not for lung function parameters. We conclude that: in patients with CF and advanced lung disease, nutritional status plays a significant role in determining exercise capacity; lower exercise tolerance of malnourished patients is an independent effect, as nutritional status and lung function were not related; and malnourished patients with CF have an altered cardiac performance on exercise testing which is due to a reduced SV rather than an impaired heart rate response.

journal_name

Chest

journal_title

Chest

authors

Marcotte JE,Canny GJ,Grisdale R,Desmond K,Corey M,Zinman R,Levison H,Coates AL

doi

10.1378/chest.90.3.375

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

375-9

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37115-X

journal_volume

90

pub_type

杂志文章

相关文献

CHEST文献大全
  • Gas flow through a bronchopleural fistula. Measuring the effects of high-frequency jet ventilation and chest-tube suction.

    abstract::High-frequency jet ventilation (HFJV) is FDA-approved for ventilating patients with bronchopleural fistulae (BPF), yet little is known about its effect on the fistula airleak. We quantitated a patient's BPF airleak during both conventional volume-cycled ventilation and HFJV. The effect of chest-tube suction (CTS) on B...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.1.210

    authors: Roth MD,Wright JW,Bellamy PE

    更新日期:1988-01-01 00:00:00

  • Successful treatment of juvenile laryngeal papillomatosis-related multicystic lung disease with cidofovir: case report and review of the literature.

    abstract::Cidofovir, a nucleoside analog antiviral agent, has been used with moderate success in the treatment of juvenile laryngeal papillomatosis (JLP) by direct intralesional injection. We report the first case where IV cidofovir was used successfully to treat a rare but lethal multicystic lung disease complicating JLP. A 35...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.118.4.1210

    authors: Dancey DR,Chamberlain DW,Krajden M,Palefsky J,Alberti PW,Downey GP

    更新日期:2000-10-01 00:00:00

  • Decortication after 35 years.

    abstract::A 66-year-old white woman had a paraffin plombage performed in 1940 for tuberculosis. In 1975, she had decortication for terminal respiratory insufficiency, with return to an active life. Thirty-five years of pulmonary compression does not produce irreversible changes in the pulmonary parenchyma. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.5.668

    authors: Knudsen DF

    更新日期:1977-05-01 00:00:00

  • Pulmonary reaction to upper mantle radiation therapy for Hodgkin's disease.

    abstract::To study the effects of upper mantle radiation therapy on pulmonary function, forced expiratory volume in one second (FEV1), vital capacity (VC), inspiratory capacity (IC), diffusing capacity for CO (DLCO) and diffusion per unit of alveolar volume (DL/VA were determined in 28 patients with Hodgkin's disease, stages 1-...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.6.688

    authors: do Pico GA,Wiley AL Jr,Rao P,Dickie HA

    更新日期:1979-06-01 00:00:00

  • Management of adult acute epiglottitis by tracheal intubation.

    abstract::We present a case of adult acute epiglottitis that was successfully managed by endotracheal intubation without the need for subsequent tracheostomy. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.1.93

    authors: Ward CF,Benumof JL,Shapiro HM

    更新日期:1977-01-01 00:00:00

  • A significant increase in breathing amplitude precedes sleep bruxism.

    abstract:BACKGROUND:Sleep bruxism (SB) is a stereotyped movement disorder that is characterized by rhythmic masticatory muscle activity (RMMA) and tooth grinding. Evidence has suggested that SB is associated with sleep arousals and that most RMMA episodes are preceded by physiologic changes occurring in sequence, namely, a rise...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-0115

    authors: Khoury S,Rouleau GA,Rompré PH,Mayer P,Montplaisir JY,Lavigne GJ

    更新日期:2008-08-01 00:00:00

  • Enoximone vs nicardipine during the early postoperative course of patients undergoing cardiac surgery. A prospective study of two therapeutic strategies.

    abstract::The hemodynamic effects of enoximone and nicardipine were compared during the early postcardiac surgery period in 40 patients with systemic hypertension and moderate cardiac dysfunction. Patients were prospectively randomized into two groups. Mean right atrial pressure was maintained above 7 mm Hg. The drug infusion r...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.106.1.52

    authors: Squara P,Denjean D,Godard P,Brunet F,Brusset A,Dubois C

    更新日期:1994-07-01 00:00:00

  • Pulmonary impairment after tuberculosis.

    abstract:BACKGROUND:Pulmonary impairment subsequent to a cure of pulmonary tuberculosis has been described only in selected populations. METHODS:We compared pulmonary function in a case-control study of 107 prospectively identified patients with pulmonary tuberculosis who had completed at least 20 weeks of therapy and 210 pati...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-2949

    authors: Pasipanodya JG,Miller TL,Vecino M,Munguia G,Garmon R,Bae S,Drewyer G,Weis SE

    更新日期:2007-06-01 00:00:00

  • Preoperative pulmonary function and complications after cardiovascular surgery.

    abstract::Results of preoperative pulmonary function tests were evaluated in 106 patients who had major thoracic or upper abdominal cardiovascular surgery. These results were related to the occurrence of postoperative complications by comparison of pulmonary function data in patients with an ICU stay of less than 5 days versus ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.2.130

    authors: Cain HD,Stevens PM,Adaniya R

    更新日期:1979-08-01 00:00:00

  • Thoracoscopic talc poudrage pleurodesis for malignant effusions. A review of 360 cases.

    abstract:OBJECTIVE:To assess the efficacy, permanence, and safety of thoracoscopic talc poudrage (TTP) for pleurodesis in malignant effusions. DESIGN:Retrospective. PARTICIPANTS:Patients with lifetime follow-up who received TTP in two related centers in Marseilles, France. RESULTS:Three hundred sixty patients were included i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.6.1387

    authors: Viallat JR,Rey F,Astoul P,Boutin C

    更新日期:1996-12-01 00:00:00

  • Evaluation and management of pill aspiration: case discussion and review of the literature.

    abstract::Pill aspiration represents a unique type of foreign body aspiration requiring a distinct diagnostic and therapeutic approach. In many cases, the "foreign body" itself may no longer be present, whereas the airway manifestations may persist for months to years. Limited data exist to guide management decisions. We report...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-1571

    authors: Kinsey CM,Folch E,Majid A,Channick CL

    更新日期:2013-06-01 00:00:00

  • Activation of bronchial epithelial cells in smokers without airway obstruction and patients with COPD.

    abstract:STUDY OBJECTIVE:The aim of this study was to investigate the basal level as well as the tumor necrosis factor (TNF)-alpha- and interferon (IFN)-gamma-induced expression and release of the neutrophil chemoattractants interleukin (IL)-8 and growth-related oncogene (GRO)-alpha in primary bronchial epithelial cells (PBECs)...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.5.1706

    authors: Schulz C,Krätzel K,Wolf K,Schroll S,Köhler M,Pfeifer M

    更新日期:2004-05-01 00:00:00

  • The endocrinometabolic effects of beclomethasone dipropionate in asthmatic patients.

    abstract::The endocrinometabolic effects of the aerosol administration of beclomethasone dipropionate (100 microng four times daily) were evaluated in 20 asthmatic patients (11 corticodependent and nine noncorticodependent) during one month. In the noncorticodependent group, aerosol administration of beclomethasone had no stati...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.6.698

    authors: Yernault JC,Leclercq R,Schandevyl W,Virasoro E,De Coster A,Copinschi G

    更新日期:1977-06-01 00:00:00

  • The natural history of radiographically occult bronchogenic squamous cell carcinoma: a retrospective study of overdiagnosis bias.

    abstract:OBJECTIVE:An overdiagnosis bias occurs with the diagnosis of a disease that does not produce signs or symptoms before the patient dies from other causes. We sought to determine whether overdiagnosis bias is a factor when screening for squamous cell carcinoma of the lung. DESIGN:Retrospective study of the Miyagi Popula...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.126.1.108

    authors: Sato M,Saito Y,Endo C,Sakurada A,Feller-Kopman D,Ernst A,Kondo T

    更新日期:2004-07-01 00:00:00

  • Combination antihypertensive therapy among patients with COPD.

    abstract:BACKGROUND:COPD and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform the selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-1770

    authors: Herrin MA,Feemster LC,Crothers K,Uman JE,Bryson CL,Au DH

    更新日期:2013-05-01 00:00:00

  • Prediction of successful ventilator weaning using airway occlusion pressure and hypercapnic challenge.

    abstract::We studied eleven patients during 14 attempts at weaning from mechanical ventilation to determine whether central ventilatory drive, measured as airway occlusion pressure 0.1 s after onset of inspiration (P 0.1), during spontaneous breathing before and during a brief hypercapnic challenge, could accurately predict the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.4.496

    authors: Montgomery AB,Holle RH,Neagley SR,Pierson DJ,Schoene RB

    更新日期:1987-04-01 00:00:00

  • Long-term results of neoadjuvant ifosfamide, cisplatin, and etoposide combination in locally advanced non-small-cell lung cancer.

    abstract::Thirty-three patients with T3,N2,M0 or T4,N2,M0, non-small-cell lung cancer (NSCLC) took part in a phase 2 study in an attempt to evaluate the feasability of neoadjuvant chemotherapy followed by surgery and thoracic radiotherapy. Chemotherapy consisted of daily administration of the following treatment: etoposide, 100...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.106.5.1451

    authors: Pujol JL,Hayot M,Rouanet P,Le Chevalier T,Michel FB

    更新日期:1994-11-01 00:00:00

  • Nearly fatal idiopathic anaphylactic reaction resulting in cardiovascular collapse and myocardial infarction.

    abstract::We report a case of nearly fatal cardiovascular collapse attributable to an idiopathic anaphylactic reaction in a 76-year-old man. The event began with gastrointestinal symptoms of abdominal cramps, diarrhea, nausea, and vomiting as manifestations of IA. The patient subsequently progressed to develop urticaria, flushi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.2.501

    authors: Wong S,Greenberger PA,Patterson R

    更新日期:1990-08-01 00:00:00

  • Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial.

    abstract:STUDY OBJECTIVE:Our group performed a randomized trial to assess whether the addition of endobronchial ultrasound (EBUS) guidance will lead to better results than standard transbronchial needle aspiration (TBNS). EBUS guidance seems to be beneficial in increasing the yield of TBNA but has not been proven to be superior...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.125.1.322

    authors: Herth F,Becker HD,Ernst A

    更新日期:2004-01-01 00:00:00

  • Coagulation activation and organ dysfunction following cardiac surgery.

    abstract:STUDY OBJECTIVES:Cardiac surgery with cardiopulmonary bypass (CPB) is associated with major inflammatory triggers that cause marked activation of the microcirculation. This inflammatory response is associated with significant organ dysfunction. How this response causes organ dysfunction is not well understood; conseque...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.1.229

    authors: Dixon B,Santamaria J,Campbell D

    更新日期:2005-07-01 00:00:00

  • Pericarditis with effusion casued by Actinomyces israelii.

    abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.5.680

    authors: Schlossberg D,Franco-Jove D,Woodward C,Shulman J

    更新日期:1976-05-01 00:00:00

  • Successful Healing of Tracheal Radionecrosis: Role of Hyperbaric Oxygen Therapy.

    abstract::Hyperbaric oxygen therapy, the administration of 100% oxygen at pressures > 1 atm, is believed to promote wound healing by increasing angiogenesis and collagen synthesis. To our knowledge, this treatment modality has never been described in patients with tracheal radionecrosis. Here, we report the case of a 55-year-ol...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.03.027

    authors: Ariza-Prota M,Morales A,Grajeda J,López-Lisbona R,Cubero N,Dorca J,Rosell A

    更新日期:2016-12-01 00:00:00

  • Positive end-expiratory pressure vs T-piece. Extubation after mechanical ventilation.

    abstract::Because T-piece breathing may impair oxygenation, the best airway pressure from which to extubate ventilated patients is controversial. We compared the effects of extubation after 1 h of either CPAP 5 and T-piece/ZEEP. Once weaned from mechanical ventilation and breathing spontaneously, 106 patients were randomized to...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.100.6.1655

    authors: Jones DP,Byrne P,Morgan C,Fraser I,Hyland R

    更新日期:1991-12-01 00:00:00

  • Treatment of the adult respiratory distress syndrome with continuous positive airway pressure.

    abstract::Fifteen patients in the early stages of the adult respiratory distress syndrome with severe hypoxemia who were capable of maintaining adequate spontaneous ventilation were treated with continuous positive airway pressure (CPAP). The optimal level of CPAP was adjusted for each patient to achieve the highest oxygenation...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.3.257

    authors: Venus B,Jacobs HK,Lim L

    更新日期:1979-09-01 00:00:00

  • New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6.

    abstract::Serum levels of a high molecular weight circulating antigen KL-6, detected by means of a sandwich assay using a monoclonal antibody KL-6 against a sialylated carbohydrate antigen, were evaluated for usefulness in monitoring the activity of interstitial pneumonitis. Abnormally high levels of KL-6 antigen were observed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.1.68

    authors: Kohno N,Kyoizumi S,Awaya Y,Fukuhara H,Yamakido M,Akiyama M

    更新日期:1989-07-01 00:00:00

  • Better With Ultrasound: Transesophageal Echocardiography.

    abstract::Transesophageal echocardiography (TEE) is a safe and minimally invasive tool that can routinely provide high-quality anatomic and hemodynamic information in the severely ill. Despite its potential for frontline acute care clinicians, TEE use has typically been reserved for diagnostic experts in the cardiac-surgical mi...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2018.09.023

    authors: Jaidka A,Hobbs H,Koenig S,Millington SJ,Arntfield RT

    更新日期:2019-01-01 00:00:00

  • Mid-systolic sound associated with aortic insufficiency and bisferiens pulse.

    abstract::Systolic ejection clicks, often associated with cardiac disease, can be distinguished from mid-systolic clicks of mitral and tricuspid origin, which are frequently benign. A different mid-systolic sound has been recognized, with timing similar to the mid-systolic clicks, which is associated with aortic insufficiency. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.1.141

    authors: Robertson WS,Tavel ME

    更新日期:1983-01-01 00:00:00

  • Pneumothorax in the ICU: patient outcomes and prognostic factors.

    abstract:STUDY OBJECTIVE:To identify the prognostic factors for pneumothorax in patients in the ICU. DESIGN:Retrospective cohort study. SETTING:ICU at a university-based teaching hospital. PATIENTS AND METHODS:Sixty patients developed pneumothoraces in the ICU during a period of 36 months. Medical records relating to patient...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.122.2.678

    authors: Chen KY,Jerng JS,Liao WY,Ding LW,Kuo LC,Wang JY,Yang PC

    更新日期:2002-08-01 00:00:00

  • Perioperative risk factors for anastomotic leakage after esophagectomy: influence of thoracic epidural analgesia.

    abstract:STUDY OBJECTIVES:Anastomotic leakage after esophagectomy is associated with high postoperative morbidity and mortality. The most important predisposing factors for anastomotic leaks are ischemia of the gastric conduit and low blood oxygen content. The aim of this study was to evaluate the influence of thoracic epidural...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.5.3461

    authors: Michelet P,D'Journo XB,Roch A,Papazian L,Ragni J,Thomas P,Auffray JP

    更新日期:2005-11-01 00:00:00

  • Periodic breathing with no heart beat.

    abstract::A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-2950

    authors: Bartsch S,Haouzi P

    更新日期:2013-10-01 00:00:00