Abstract:
:The hemodynamic effects of enoximone and nicardipine were compared during the early postcardiac surgery period in 40 patients with systemic hypertension and moderate cardiac dysfunction. Patients were prospectively randomized into two groups. Mean right atrial pressure was maintained above 7 mm Hg. The drug infusion rate was adjusted to maintain mean systemic artery pressure (SAP) within the 65 to 80 mm Hg range. Complete hemodynamic evaluations were performed before any drug infusion and during the following 24 h with special attention to O2-related variables. Oxygen consumption, cardiac index, and stroke index improved significantly and similarly in the two groups. The SAP and systemic vascular resistance decreased more rapidly in the enoximone group but whole body lactate level increased after the second hour of infusion. Furthermore, this was paralleled by an arteriovenous O2 contents difference deficit. In our study, nicardipine was found superior over enoximone in terms of recovery from intraoperative tissue hypoxia. Furthermore, enoximone's inotropic effects were not found to be clinically relevant.
journal_name
Chestjournal_title
Chestauthors
Squara P,Denjean D,Godard P,Brunet F,Brusset A,Dubois Cdoi
10.1378/chest.106.1.52subject
Has Abstractpub_date
1994-07-01 00:00:00pages
52-8issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)38958-9journal_volume
106pub_type
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