The amplitude of circadian FEV1 variation suitable for phase determination by cosinor analysis in stable asthmatic children.

Abstract:

:To elucidate the criterion for amplitude of circadian FEV1 variation suitable for phase analysis, six FEV1 measurements within a day were made on 346 days in 125 stable asthmatic children aged 8 to 12 years. Since coefficient of variation (CV) of FEV1 within a day in nonasthmatic children in our laboratory is less than 5 percent, circadian FEV1 variations were divided into CV greater than or equal to 5 percent and CV less than 5 percent groups. Forty-two (12 percent) variations with significant fit of cosinor rhythm were CV greater than or equal to 5 percent. Troughs in 32 (76 percent) variations of the 42 were distributed between 12 PM and 6 AM, and the deviation was highly significant against a uniform distribution (p less than 0.001). This was consistent with nocturnal asthma. Thirty-five (10 percent) variations with significant fit of cosinor rhythm were CV less than 5 percent. Troughs in 12 (34 percent) variations of the 35 were distributed between 12 PM and 6 AM, and the deviation from a uniform distribution was nonsignificant. These suggest that 5 percent or more of CV of FEV1 may be clinically suitable for analysis of circadian FEV1 variation.

journal_name

Chest

journal_title

Chest

authors

Kondo S

doi

10.1378/chest.102.3.771

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

771-4

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)39107-3

journal_volume

102

pub_type

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