Abstract:
:To elucidate the criterion for amplitude of circadian FEV1 variation suitable for phase analysis, six FEV1 measurements within a day were made on 346 days in 125 stable asthmatic children aged 8 to 12 years. Since coefficient of variation (CV) of FEV1 within a day in nonasthmatic children in our laboratory is less than 5 percent, circadian FEV1 variations were divided into CV greater than or equal to 5 percent and CV less than 5 percent groups. Forty-two (12 percent) variations with significant fit of cosinor rhythm were CV greater than or equal to 5 percent. Troughs in 32 (76 percent) variations of the 42 were distributed between 12 PM and 6 AM, and the deviation was highly significant against a uniform distribution (p less than 0.001). This was consistent with nocturnal asthma. Thirty-five (10 percent) variations with significant fit of cosinor rhythm were CV less than 5 percent. Troughs in 12 (34 percent) variations of the 35 were distributed between 12 PM and 6 AM, and the deviation from a uniform distribution was nonsignificant. These suggest that 5 percent or more of CV of FEV1 may be clinically suitable for analysis of circadian FEV1 variation.
journal_name
Chestjournal_title
Chestauthors
Kondo Sdoi
10.1378/chest.102.3.771subject
Has Abstractpub_date
1992-09-01 00:00:00pages
771-4issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)39107-3journal_volume
102pub_type
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