Successful treatment of juvenile laryngeal papillomatosis-related multicystic lung disease with cidofovir: case report and review of the literature.

Abstract:

:Cidofovir, a nucleoside analog antiviral agent, has been used with moderate success in the treatment of juvenile laryngeal papillomatosis (JLP) by direct intralesional injection. We report the first case where IV cidofovir was used successfully to treat a rare but lethal multicystic lung disease complicating JLP. A 35-year-old woman with a history of JLP requiring multiple laser ablations of laryngeal papillomata each year presented with hemoptysis and was found on CT scan to have bilateral, multiple pulmonary nodules and cysts. The results of BAL fluid analysis demonstrated no evidence of malignancy, and cultures were negative for fungi and mycobacteria. Molecular DNA typing of a biopsy specimen obtained from a laryngeal papilloma confirmed infection with human papilloma virus type 11. She received 12 months of treatment with IV cidofovir followed by 9 months of combined treatmentwith IV cidofovir and subcutaneous interferon-alpha-2A. This therapeutic regime resulted in a markedly decreased requirement for surgical removal of laryngeal papillomata, and CT scanning documented the regression of the lesions in the lung parenchyma that persisted after the discontinuation of therapy. The results of this case demonstrate that cidofovir may be used successfully to treat JLP-related lung disease and suggest that further studies are warranted.

journal_name

Chest

journal_title

Chest

authors

Dancey DR,Chamberlain DW,Krajden M,Palefsky J,Alberti PW,Downey GP

doi

10.1378/chest.118.4.1210

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

1210-4

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37730-8

journal_volume

118

pub_type

杂志文章,评审

相关文献

CHEST文献大全
  • Evaluation of variable mandibular advancement appliance for treatment of snoring and sleep apnea.

    abstract:OBJECTIVE:To evaluate an adjustable mandibular positioning appliance for treatment of snoring and sleep apnea. METHODS:One hundred thirty-four patients with baseline apnea/hypopnea index (AHI) of 37 +/- 28 events/h (mean +/- SD) received the appliance. The efficacy of the appliance was assessed by the following invest...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.6.1511

    authors: Pancer J,Al-Faifi S,Al-Faifi M,Hoffstein V

    更新日期:1999-12-01 00:00:00

  • Acceptance of CPAP therapy for sleep apnea.

    abstract::Although NCPAP is the most efficient nonsurgical treatment for patients with OSA, many patients do not accept sleeping with a nose mask. To determine the factors influencing acceptance, treatment with NCPAP was offered to 95 patients with an AHI greater than 15. After the first night on NCPAP, 47 of 65 patients decide...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.4.1019

    authors: Rauscher H,Popp W,Wanke T,Zwick H

    更新日期:1991-10-01 00:00:00

  • Carbon dioxide excretion via bronchopleural fistulas in adult respiratory distress syndrome.

    abstract::Expired gas and gas leaked via thoracostomy tubes was collected in nine patients with the adult respiratory distress syndrome (ARDS) and bronchopleural fistulas. Mean minute ventilation in the group was 23.9 +/- 7.5 L/min with 31 +/- 23 percent of the gas escaping via the leak. Carbon dioxide was present in the leaked...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.3.400

    authors: Bishop MJ,Benson MS,Pierson DJ

    更新日期:1987-03-01 00:00:00

  • Abdominal placement of tube thoracostomy due to lack of recognition of paralysis of hemidiaphragm.

    abstract::Tube thoracostomy is an invasive procedure that carries a risk of complications. We report a patient with liver cirrhosis, ascites and large left-sided pleural effusion, in whom a trocar type chest tube was inserted at the seventh left intercostal space in the midaxillary line. Chest roentgenogram revealed that the dr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.1.292

    authors: Foresti V,Villa A,Casati O,Parisio E,De Filippi G

    更新日期:1992-07-01 00:00:00

  • Effect of inhaled norepinephrine on the nitroglycerin-induced bronchodilatation in asthmatics.

    abstract::Previous studies on the bronchodilating effect of nitrates yielded conflicting results. We hypothesized that the concomitant bronchial vasodilatation induced by nitrates may limit the increase of airway patency due to bronchial smooth muscle relaxation. To test this hypothesis, we evaluated the bronchodilating effect ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.107.1.169

    authors: Rolla G,Bucca C,Brussino L

    更新日期:1995-01-01 00:00:00

  • Hemolysis in the aortic prosthetic valve.

    abstract::A review of the incidence and severity of hemolysis in the aortic prosthesis is presented. The noncloth-covered Starr-Edwards prosthetic series 1000, 1200, and 1260 had a 2 percent (1/54) incidence of anemia. The cloth-covered Starr-Edwards aortic prosthetic series 2300 was associated with anemia in 61 percent (28/46)...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.1.56

    authors: Santinga JT,Batsakis JT,Flora JD,Kirsh MM

    更新日期:1976-01-01 00:00:00

  • An analysis of in vitro T cell responsiveness in nontuberculous mycobacterial infection.

    abstract::In vitro cell-mediated immunity was examined in patients infected with nontuberculous mycobacteria, Mycobacterium avium-intracellulare complex in Japan. Peripheral blood lymphocytes of patients, as compared with those of tuberculous patients or tuberculin-positive healthy donors, showed depressed in vitro blastogenic ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.4.822

    authors: Tsuyuguchi I,Shiratsuchi H,Okuda Y,Yamamoto Y

    更新日期:1988-10-01 00:00:00

  • Health-related quality of life of persons with sarcoidosis.

    abstract:STUDY OBJECTIVES:To describe the health-related quality of life (HRQL) and mental health of persons with sarcoidosis, as well as to assess physician-patient agreement about the presence of sarcoidosis symptoms. DESIGN AND SETTING:Cross-sectional study at three university medical center outpatient pulmonary clinics. P...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.3.997

    authors: Cox CE,Donohue JF,Brown CD,Kataria YP,Judson MA

    更新日期:2004-03-01 00:00:00

  • Air within the spinal canal in spontaneous pneumomediastinum.

    abstract::Spontaneous pneumomediastinum is an uncommon benign condition that is occasionally associated with air within the spinal canal. We describe a further case in a 14-year-old girl and suggest a classification system based on a detailed review of the previous literature. Forty-eight patients with spontaneous pneumomediast...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.09-0514

    authors: Belotti EA,Rizzi M,Rodoni-Cassis P,Ragazzi M,Zanolari-Caledrerari M,Bianchetti MG

    更新日期:2010-05-01 00:00:00

  • Performance measurement through audit, feedback, and profiling as tools for improving clinical care.

    abstract::Clinical audits and practice profiling have become popular tools in the attempt to change physician behavior to improve quality of care. Unfortunately, the growing need for information on quality of care has often outpaced the development of standard, valid, and reliable approaches to using these tools. The studies of...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.118.2_suppl.53s

    authors: Weiss KB,Wagner R

    更新日期:2000-08-01 00:00:00

  • Bronchial hyperreactivity in patients with moderate pulmonary circulation overload.

    abstract::The clinical course of congestive heart failure (CHF) and mitral valve stenosis (MVS) is accompanied by episodes of dyspnea, wheezing, and cough, symptoms also observed in patients with bronchial hyperreactivity. However, it is still controversial whether bronchial hyperreactivity is demonstrable in patients with chro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.5.1477

    authors: Brunnée T,Graf K,Kastens B,Fleck E,Kunkel G

    更新日期:1993-05-01 00:00:00

  • Automated surveillance for ventilator-associated events.

    abstract:BACKGROUND:The US Centers for Disease Control and Prevention has implemented a new, multitiered definition for ventilator-associated events (VAEs) to replace their former definition of ventilator-associated pneumonia (VAP). We hypothesized that the new definition could be implemented in an automated, efficient, and rel...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-2255

    authors: Stevens JP,Silva G,Gillis J,Novack V,Talmor D,Klompas M,Howell MD

    更新日期:2014-12-01 00:00:00

  • Safety of over-the-counter inhalers for asthma: report of the council on scientific affairs.

    abstract::The occasional use of over-the-counter (OTC) epinephrine inhalers appears to be safe and effective when used according to labeled instruction by individuals with mild, intermittent asthma. However, gross misuse of these products can cause severe adverse reactions, including death. Limited survey data suggest that appr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.522

    authors: Dickinson BD,Altman RD,Deitchman SD,Champion HC

    更新日期:2000-08-01 00:00:00

  • Cardiac tamponade secondary to giant lymph node hyperplasia (Castleman's disease)

    abstract::A unique association of giant lymph node hyperplasia (Castleman's disease) and cardiac tamponade is presented. Although pleural effusions have been previously described with Castleman's disease, the authors believe this to be the first report of pericardial effusion and tamponade with this entity. The development of e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.2.637

    authors: Nicolosi AC,Almassi GH,Komorowski R

    更新日期:1994-02-01 00:00:00

  • Successful treatment of primary pulmonary angiosarcoma.

    abstract::Angiosarcoma in the lung is an uncommon disorder and is usually attributable to metastasis from a primary site. Primary pulmonary angiosarcoma is extremely rare, and the prognosis of affected individuals is dismal, with most patients dying within months of presentation. Indeed, there have been no reported instances of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.6.2397

    authors: Kojima K,Okamoto I,Ushijima S,Yoshinaga T,Kitaoka M,Suga M,Sasaki Y

    更新日期:2003-12-01 00:00:00

  • Assessment of interrater and intrarater reliability in the evaluation of metered dose inhaler technique.

    abstract:STUDY OBJECTIVE:To determine if a training session using videotaped metered dose inhaler (MDI) performances can result in high interrater and intrarater reliability of five evaluators assessing MDI technique. DESIGN:Five evaluators (three pharmacists, two pulmonary fellows) were trained to evaluate MDI technique durin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.3.710

    authors: Gray SL,Nance AC,Williams DM,Pulliam CC

    更新日期:1994-03-01 00:00:00

  • Thoracoscopy and video-assisted thoracic surgery in the treatment of lung cancer.

    abstract::The contemporary surgical repertoire for the evaluation and treatment of patients with lung cancer includes the bronchoscope, mediastinoscope, thoracoscope, and standard surgical instrumentation. The recent advances in video optics and the development of endoscopic instruments have significantly expanded the surgical ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.6_supplement.298s

    authors: Mentzer SJ,DeCamp MM,Harpole DH Jr,Sugarbaker DJ

    更新日期:1995-06-01 00:00:00

  • The effect of a computerized reminder system on the prevention of postoperative venous thromboembolism.

    abstract:STUDY OBJECTIVE:To measure the effect of an altered process of care, directed by a computerized reminder system, on rates of symptomatic postoperative venous thromboembolism. DESIGN:Comparisons of preintervention and postintervention measurements. SETTING:A university-affiliated community hospital in Utah. PATIENTS:...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.125.5.1635

    authors: Mosen D,Elliott CG,Egger MJ,Mundorff M,Hopkins J,Patterson R,Gardner RM

    更新日期:2004-05-01 00:00:00

  • Palliative Care in Advanced Lung Disease: The Challenge of Integrating Palliation Into Everyday Care.

    abstract::The tendency toward "either/or" thinking (either cure or comfort) in traditional biomedical care paradigms does little to optimize care in advancing chronic illness. Calls for improved palliation in chronic lung disease mandate a review of related care gaps and current clinical practices. Although specialist palliativ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-2593

    authors: Rocker GM,Simpson AC,Horton R

    更新日期:2015-09-01 00:00:00

  • Reversibility of airways injury over a 12-month period following smoking cessation.

    abstract::In this investigation, we examined changes in exfoliated tracheobronchial cells in sputum in 46 individuals (mean age = 49.2 years; mean packyears = 48.7) who discontinued smoking and 37 individuals (mean age = 54.9 years; mean packyears = 65.2) who continued to smoke over a 12-month period after participation in the ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.3.607

    authors: Swan GE,Hodgkin JE,Roby T,Mittman C,Jacobo N,Peters J

    更新日期:1992-03-01 00:00:00

  • Thrombolysis with tissue plasminogen activator in suspected acute myocardial infarction. The ASSET Study.

    abstract::Intravenous rtPA (total dose, 100 mg over 3 h) was compared with placebo in a prospective, randomized, double-blind trial in 5,011 patients with suspected AMI of less than 5 h duration. No ECG or enzymatic confirmation of the diagnosis was required for study entry. At 1 month 9.8% of patients given placebo had died co...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Wilcox RG

    更新日期:1989-05-01 00:00:00

  • Nd-YAG laser vs bronchoscopic electrocautery for palliation of symptomatic airway obstruction: a cost-effectiveness study.

    abstract:STUDY OBJECTIVE:To evaluate the cost effectiveness of the Nd-YAG laser and bronchoscopic electrocautery for palliation in patients with symptomatic tumor obstruction. DESIGN:A retrospective study. SETTING:Bronchoscopy unit of a university hospital. PATIENTS AND INTERVENTION:Thirty-one consecutive patients with inope...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.4.1108

    authors: Boxem Tv,Muller M,Venmans B,Postmus P,Sutedja T

    更新日期:1999-10-01 00:00:00

  • The use of 201thallium for myocardial perfusion imaging in sarcoid heart disease.

    abstract::Cardiac dysfunction due to systemic sarcoidosis is most of ten due to severe restrictive pulmonary diseases. Although the diagnosis is frequently missed during life, direct granulomatous infiltration of the myocardium may occur with systemic sarcoidosis and, when present in the heart, is a major cause of death. To exp...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.1.27

    authors: Bulkley BH,Rouleau JR,Whitaker JQ,Strauss HW,Pitt B

    更新日期:1977-07-01 00:00:00

  • Clinical Approach to the Therapy of Asthma-COPD Overlap.

    abstract::Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinica...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2018.07.028

    authors: Maselli DJ,Hardin M,Christenson SA,Hanania NA,Hersh CP,Adams SG,Anzueto A,Peters JI,Han MK,Martinez FJ

    更新日期:2019-01-01 00:00:00

  • Heimlich valve treatment of Pneumocystis carinii-associated pneumothorax.

    abstract::Two patients were treated for AIDS-associated bilateral pneumothoraces which persisted despite prolonged chest tube drainage. Heimlich flutter valves were used to facilitate the outpatient management of these patients. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.1.281

    authors: Driver AG,Peden JG,Adams HG,Rumley RL

    更新日期:1991-07-01 00:00:00

  • Single-breath nitrogen washout; effects of alterations of lung volumes and elastic recoil.

    abstract::Strapping of the chest causes decreased lung volumes and increased elastic recoil pressure. Such strapping was used in conjunction with single-breath nitrogen washout to study the effects of changes in these factors on the dynamics of the small airways. Studies consisted of simultaneous measurements of the quasistatic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.1.83

    authors: Al-Bazzaz FJ

    更新日期:1979-07-01 00:00:00

  • Regional differences in emphysema scores and BAL glutathione levels in HIV-infected individuals.

    abstract:STUDY OBJECTIVES:Evidence exists that HIV-seropositive individuals may be at increased risk for the development of precocious pulmonary emphysema. HIV infection is also associated with antioxidant deficiency in both the serum and lungs, and it is therefore possible that increased oxidant stress may contribute to parenc...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.126.5.1439

    authors: Diaz PT,Wewers MD,King M,Wade J,Hart J,Clanton TL

    更新日期:2004-11-01 00:00:00

  • The preventable burden of productivity loss due to suboptimal asthma control: a population-based study.

    abstract:BACKGROUND:Productivity loss is an overlooked aspect of the burden of chronic health conditions. While modern guidelines emphasize achieving clinical control in asthma management, few studies have reported on the relationship between asthma control and productivity loss. We calculated the productivity loss that can be ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-1619

    authors: Sadatsafavi M,Rousseau R,Chen W,Zhang W,Lynd L,FitzGerald JM

    更新日期:2014-04-01 00:00:00

  • Diagnosis and treatment of cystic fibrosis. An update.

    abstract::Cystic fibrosis is the most common fatal inherited disease of Caucasians. At present, cystic fibrosis accounts for most cases of chronic progressive pulmonary disease and for many other clinical features in the first three decades of life. Thus, it is a challenge to both pediatricians and internists, particularly ches...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/s0012-3692(16)62421-2

    authors: Davis PB,di Sant'Agnese PA

    更新日期:1984-06-01 00:00:00

  • An unusual case of left upper lobe pulmonary edema.

    abstract::This is a report of an unusual case of left, predominantly upper lobe, pulmonary edema secondary to paravalvular mitral regurgitation (MR) complicating mitral valve replacement. Transesophageal echocardiography proved helpful in making the diagnosis of MR and suggesting the mechanism of the pulmonary edema. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.1.328

    authors: Rice J,Roth SL,Rossoff LJ

    更新日期:1998-07-01 00:00:00