Clinical Approach to the Therapy of Asthma-COPD Overlap.

Abstract:

:Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinical outcomes and increased health-care utilization than those with asthma or COPD. Therefore, there is a critical need to set a framework for the therapeutic approach of such patients. There are key distinctions in the therapy between asthma and COPD, particularly regarding the initial choice of therapy. However, there is considerable overlap in the use of existing medications for both diseases. Furthermore, novel therapies approved for asthma, such as monoclonal antibodies, may have a role in patients with COPD and ACO. The use of biomarkers, such as peripheral blood eosinophils, exhaled nitric oxide, and serum IgE, may help in selecting appropriate therapies for ACO. In this review, we provide an overview of available treatments for both asthma and COPD and explore their potential role in the treatment of patients with ACO.

journal_name

Chest

journal_title

Chest

authors

Maselli DJ,Hardin M,Christenson SA,Hanania NA,Hersh CP,Adams SG,Anzueto A,Peters JI,Han MK,Martinez FJ

doi

10.1016/j.chest.2018.07.028

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

168-177

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(18)31129-2

journal_volume

155

pub_type

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