Reperfusion adequacy and functional recovery.

Abstract:

:Ischemic myocardium undergoes many physiologic changes, including alterations in contractile function, histologic condition, and oxygen utilization. Reperfusion of ischemic myocardium may reverse some of these changes; however, the level of reperfusion needed for adequate functional recovery, as opposed to myocyte salvage, remains controversial. This study examines the effects of varying levels of reperfusion following ischemia on functional parameters of recovery. Isolated rabbit hearts were subjected to global ischemia at 37 degrees C for 10, 20, or 45 min. The hearts were reperfused at either mean normal baseline pressure (80 mm Hg), one half baseline (40 mm Hg), or one fourth baseline (20 mm Hg). With reperfusion, although all hearts retained the compensatory metabolic ability to upregulate oxygen extraction, reduction of reperfusion pressure resulted in depression of contractility and myocardial oxygen consumption, especially with low-pressure reperfusion. These findings suggest that all levels of reperfusion are not equal for optimal myocardial functional recovery. As minimal reperfusion may result in persistent stunning of myocardium, other means of enhancing reperfusion, such as percutaneous transluminal coronary angioplasty or coronary artery bypass grafting, should be considered.

journal_name

Chest

journal_title

Chest

authors

Rohs TJ Jr,Benedict MB,Bolling SF

doi

10.1378/chest.112.4.1075

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1075-8

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)47236-8

journal_volume

112

pub_type

杂志文章

相关文献

CHEST文献大全
  • Expression of CXC chemokine receptors 1 and 2 in human bronchial epithelial cells.

    abstract:INTRODUCTION:CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2 (CXCR2) have been shown to play an important role in transepithelial migration of neutrophil granulocytes during inflammation in various tissues. This study investigated the regulation of gene expression and surface expression of CXCR1 and CXCR2...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.5.3724

    authors: Farkas L,Hahn MC,Schmoczer M,Jentsch N,Krätzel K,Pfeifer M,Schulz C

    更新日期:2005-11-01 00:00:00

  • Use of small-bore vs large-bore chest tubes for treatment of malignant pleural effusions.

    abstract:STUDY OBJECTIVE:To evaluate the efficacy of small-bore (12 French vanSonnenberg) catheters compared with standard large-bore chest tubes in the drainage and sclerotherapy of malignant pleural effusions. DESIGN:Retrospective review. SETTING:An academic tertiary care hospital. PATIENTS:Adult patients with documented n...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.1.19

    authors: Parulekar W,Di Primio G,Matzinger F,Dennie C,Bociek G

    更新日期:2001-07-01 00:00:00

  • A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 1: radiologic characteristics and imaging modalities.

    abstract::The solitary pulmonary nodule (SPN) is frequently encountered on chest imaging and poses an important diagnostic challenge to clinicians. The differential diagnosis is broad, ranging from benign granulomata and infectious processes to malignancy. Important concepts in the evaluation of SPNs include the definition, mor...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-0960

    authors: Patel VK,Naik SK,Naidich DP,Travis WD,Weingarten JA,Lazzaro R,Gutterman DD,Wentowski C,Grosu HB,Raoof S

    更新日期:2013-03-01 00:00:00

  • The effect of exercise on ischemic mitral regurgitation.

    abstract::This study investigated the effect of dynamic exercise on mitral regurgitation (MR) as assessed by color flow Doppler imaging and tested the hypothesis that MR increases in patients with left ventricular (LV) function worsening during exercise. We studied 513 patients (390 men, 123 women:mean age [+/-1 SD] 58+/-11 yea...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.4.1075

    authors: Peteiro J,Freire E,Montserrat L,Castro-Beiras A

    更新日期:1998-10-01 00:00:00

  • Nonfebrile mitral valve endocarditis due to Neisseria subflava.

    abstract::Native valve endocarditis normally presents with fever and only later in its course demonstrates dysfunction of the affected valve. We describe a case of endocarditis due to Neisseria subflava, a Gram-negative diplococcal saprophyte of the oral cavity, which was unsuspected clinically and found unexpectedly during a m...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.109.1.280

    authors: Amsel BJ,Moulijn AC

    更新日期:1996-01-01 00:00:00

  • New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6.

    abstract::Serum levels of a high molecular weight circulating antigen KL-6, detected by means of a sandwich assay using a monoclonal antibody KL-6 against a sialylated carbohydrate antigen, were evaluated for usefulness in monitoring the activity of interstitial pneumonitis. Abnormally high levels of KL-6 antigen were observed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.1.68

    authors: Kohno N,Kyoizumi S,Awaya Y,Fukuhara H,Yamakido M,Akiyama M

    更新日期:1989-07-01 00:00:00

  • Obstructive sleep apnea and resistant hypertension: a case-control study.

    abstract:BACKGROUND:Obstructive sleep apnea syndrome (OSAS) has been linked to resistant hypertension, but the magnitude of this association and its independence of confounding have not been established. METHODS:Case patients were 63 patients with resistant hypertension (BP >or= 140/90 mm Hg using at least three BP-lowering dr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.07-1170

    authors: Gonçalves SC,Martinez D,Gus M,de Abreu-Silva EO,Bertoluci C,Dutra I,Branchi T,Moreira LB,Fuchs SC,de Oliveira AC,Fuchs FD

    更新日期:2007-12-01 00:00:00

  • Gender differences in the clinical characteristics among Japanese patients with obstructive sleep apnea syndrome.

    abstract:BACKGROUND:Gender differences in the prevalence of various manifestations of obstructive sleep apnea syndrome (OSAS) is not as great as previously believed. The aim of the present study was to clarify the clinical patient characteristics of Japanese women and men with OSAS. METHODS:A cross-sectional case-match control...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-1414

    authors: Yukawa K,Inoue Y,Yagyu H,Hasegawa T,Komada Y,Namba K,Nagai N,Nemoto S,Sano E,Shibusawa M,Nagano N,Suzuki M

    更新日期:2009-02-01 00:00:00

  • Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.

    abstract:BACKGROUND:Asthma therapy is typically prescribed and titrated based on patient or parent self-report of symptoms. No longitudinal studies have assessed the relationship between symptoms and severe asthma exacerbations in children. The goal of our study was (1) to assess the association of asthma symptoms with severe a...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.10-2794

    authors: Wu AC,Tantisira K,Li L,Schuemann B,Weiss ST,Fuhlbrigge AL,Childhood Asthma Management Program Research Group.

    更新日期:2011-07-01 00:00:00

  • Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis.

    abstract::This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic ac...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.4.1025

    authors: Nadler JP,Berger J,Nord JA,Cofsky R,Saxena M

    更新日期:1991-04-01 00:00:00

  • Clinical significance of a multiple biomarker assay in patients with lung cancer. A study with logistic regression analysis.

    abstract::The relative usefulness of a combination of some tumor markers, such as CEA, AFP, ferritin and NSE for the diagnosis of lung cancer was assessed by multiple logistic analysis. Serum concentration of these markers was determined in 68 patients with lung cancer (50 with NSCLC and 18 with SCLC, in 68 patients with benign...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.3.639

    authors: Lombardi C,Tassi GF,Pizzocolo G,Donato F

    更新日期:1990-03-01 00:00:00

  • Comparison of Dynamic Expiratory CT With Bronchoscopy for Diagnosing Airway Malacia: A Pilot Evaluation.

    abstract:OBJECTIVE:To assess the accuracy of dynamic expiratory CT for detecting airway malacia using bronchoscopy as the diagnostic "gold standard." MATERIALS AND METHODS:A computerized hospital information system was used to retrospectively identify all patients with bronchoscopically proven airway malacia referred for CT ai...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-2164

    authors: Lee KS,Sun MRM,Ernst A,Feller-Kopman D,Majid A,Boiselle PM

    更新日期:2007-03-01 00:00:00

  • Psychometric Validation of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT) Questionnaire: Results of the SYMPHONY Trial.

    abstract:BACKGROUND:Disease-specific patient-reported outcome (PRO) instruments are important in assessing the impact of disease and treatment. The Pulmonary Arterial Hypertension-Symptoms and Impact Questionnaire is the first instrument for quantifying pulmonary arterial hypertension (PAH) symptoms and impacts developed accord...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.chest.2018.04.027

    authors: Chin KM,Gomberg-Maitland M,Channick RN,Cuttica MJ,Fischer A,Frantz RP,Hunsche E,Kleinman L,McConnell JW,McLaughlin VV,Miller CE,Zamanian RT,Zastrow MS,Badesch DB

    更新日期:2018-10-01 00:00:00

  • Characterization of chronic fatigue in patients with sarcoidosis in clinical remission.

    abstract:BACKGROUND:Patients with sarcoidosis frequently complain of fatigue, even when sarcoidosis has come into clinical remission. The primary aim of this study was to assess the severity of fatigue in patients with sarcoidosis in clinical remission and to characterize it according to the international criteria for chronic f...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-2629

    authors: Korenromp IHE,Heijnen CJ,Vogels OJM,van den Bosch JMM,Grutters JC

    更新日期:2011-08-01 00:00:00

  • A 37-Year-Old Man With Pleuritic Chest Pain.

    abstract:CASE PRESENTATION:A 37-year-old man with poorly controlled type 2 diabetes presented with severe right-sided pleuritic chest pain, respiratory splinting, and cough. Two weeks earlier, he had been evaluated at an urgent care for cough and was prescribed a 5-day course of azithromycin for bronchitis. He then presented to...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.02.002

    authors: Galant-Swafford J,Light M,Onaitis MW,Rawlings SA,Fierer J,Landsberg JW

    更新日期:2019-07-01 00:00:00

  • A review of why and how we may use beta-blockers in congestive heart failure.

    abstract::The history of the use of beta-blockers for congestive heart failure, beginning with the innovative seminal study by the Swedish group in 1975 to studies in 1995, is reviewed and shows that almost all trials favored the use of beta-blockers. They tended to demonstrate an increase in ejection fraction, a decrease in le...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.3.800

    authors: Constant J

    更新日期:1998-03-01 00:00:00

  • Diastolic rumbles in normally functioning porcine mitral valves.

    abstract::Fourteen of 22 patients (64%) with normally functioning porcine prosthetic valves in the mitral position had apical diastolic rumbles on phonocardiogram and by auscultation. Six (27%) had opening snaps. Factors necessary for the production of a diastolic rumble appear to include central flow, a flexible stent, and the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.2.189

    authors: Mirro MJ,Phyhel HJ,Wann LS,Weyman AE,Tavel ME,Stewart J

    更新日期:1978-02-01 00:00:00

  • Carcinomatous and tuberculous pleural effusions. Comparison of tumor markers.

    abstract::As an aid in the differential diagnosis of exudative pleural effusions, tumor markers were investigated. We measured immunosuppressive acidic protein (IAP), carbohydrate antigen 19-9 (CA 19-9), tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), adenosine deaminase (ADA), and alpha 1-acid glycoprotein (A...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.87.3.351

    authors: Niwa Y,Kishimoto H,Shimokata K

    更新日期:1985-03-01 00:00:00

  • An Audit of medical thoracoscopy and talc poudrage for pneumothorax prevention in advanced COPD.

    abstract:OBJECTIVES:To prospectively study all patients with COPD and spontaneous pneumothorax (SP) who underwent thoracoscopic talc poudrage (TP) under local anesthesia to determine its efficacy and safety in recurrence prevention. METHODS:Data on clinical measurements, complications, duration of chest tube drainage, length o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.4.1315

    authors: Lee P,Yap WS,Pek WY,Ng AW

    更新日期:2004-04-01 00:00:00

  • Diaphragm muscle thinning in patients who are mechanically ventilated.

    abstract:BACKGROUND:Approximately 40% of patients in medical ICUs require mechanical ventilation (MV). Approximately 20% to 25% of these patients will encounter difficulties in discontinuing MV. Multiple studies have suggested that MV has an unloading effect on the respiratory muscles that leads to diaphragmatic atrophy and dys...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-1638

    authors: Grosu HB,Lee YI,Lee J,Eden E,Eikermann M,Rose KM

    更新日期:2012-12-01 00:00:00

  • Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. An international, multicenter, prospective survey.

    abstract::An international, multicenter, prospective survey has been conducted to determine the hospital survival rates of patients with potentially reversible acute respiratory failure (ARF) who are managed in sophisticated intensive care units by leading critical care specialists, using current (1991 to 1992) support and trea...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.107.4.1083

    authors: Vasilyev S,Schaap RN,Mortensen JD

    更新日期:1995-04-01 00:00:00

  • The effects of macrolides on inflammatory cells.

    abstract::Bronchial epithelial damage and mucus hypersecretion are characteristic features of chronic airway inflammation that can impair mucociliary clearance and can cause recurrent or persistent respiratory infection. In response to chemoattractants produced by damaged or inflamed tissue, neutrophils move through sequential ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.125.2_suppl.41s

    authors: Tamaoki J

    更新日期:2004-02-01 00:00:00

  • Pneumonia in allogenic and autologous bone marrow recipients. A retrospective study.

    abstract::Pulmonary infections, which frequently occur during the early and late period following bone marrow transplantation for hematologic malignancies, are associated with significant morbidity and mortality. In this study the incidence, the infectious causes of pneumonia and the mortality related to pneumonia in 130 alloge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.2.371

    authors: Gentile G,Micozzi A,Girmenia C,Iori AP,Donati PP,Capria S,Martino P

    更新日期:1993-08-01 00:00:00

  • Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking.

    abstract:STUDY OBJECTIVE:To determine the indications for preoperative localization of a small indeterminate pulmonary nodule. DESIGN:In this retrospective study, univariate and multivariate analyses were performed by the logistic regression procedure. SETTING:A single National Cancer Center Hospital in Japan. PATIENTS:A ser...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.2.563

    authors: Suzuki K,Nagai K,Yoshida J,Ohmatsu H,Takahashi K,Nishimura M,Nishiwaki Y

    更新日期:1999-02-01 00:00:00

  • Upper airway dysfunction in olivopontocerebellar atrophy.

    abstract::We report the findings in a patient known to have olivopontocerebellar atrophy who developed respiratory distress, inspiratory stridor, and maximum inspiratory and expiratory flow volume loops. Treatment with carbidopa-levodopa gave symptomatic relief. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.4.1291

    authors: Schiffman PL,Golbe LI

    更新日期:1992-10-01 00:00:00

  • Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma.

    abstract:OBJECTIVES:A fixed combination of long-acting beta(2)-agonists (LABA) plus inhaled corticosteroids (ICS) has never been proven to reduce asthma exacerbations vs ICS alone in children. This 12-month, double-blind, randomized study in 341 children (age range, 4 to 11 years) with asthma uncontrolled on ICS investigated wh...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.130.6.1733

    authors: Bisgaard H,Le Roux P,Bjåmer D,Dymek A,Vermeulen JH,Hultquist C

    更新日期:2006-12-01 00:00:00

  • Retrieval of embolized central venous catheters by a Dormia ureteral stone dislodger with straight filiform tip.

    abstract::Two cases are presented in which a Dormia ureteral stone dislodger with straight filiform tip was used to retrieve broken central venous pressure catheters from the right side of the heart and vena cavae. It should be emphasized that this particular model is more easily passed into the vascular system and more easily ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.3.435

    authors: Drabinsky M

    更新日期:1976-03-01 00:00:00

  • Genetics of asthma and COPD. Similar results for different phenotypes.

    abstract::Asthma and COPD are common respiratory diseases that are caused by the interaction of genetic susceptibility with environmental factors. Environmental influences are important in both diseases, and although there are differences in genetic susceptibilities, there are also similarities. Three examples of interest for b...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.126.2_suppl_1.105S

    authors: Meyers DA,Larj MJ,Lange L

    更新日期:2004-08-01 00:00:00

  • A survey of asthma care in managed care organizations: results from the Chicago Asthma Surveillance Initiative.

    abstract:INTRODUCTION:Managed care, both via staff model health maintenance plans and nonstaff model plans, has become a major source of health-care funding in the United States. However, very little is known about the asthma-specific products and services offered by these plans. The purpose of this study is to examine the asth...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.suppl_2.173s

    authors: Nelson SG,Grant EN,Trubitt MJ,Foggs MB,Weiss KB

    更新日期:1999-10-01 00:00:00

  • Lack of efficacy for a cervicomandibular support collar in the management of obstructive sleep apnea.

    abstract:STUDY OBJECTIVES:The effect of therapy using a cervicomandibular support collar (CMSC) to manage obstructive sleep apnea (OSA) was compared with standard therapy, nasal continuous positive airway pressure (nCPAP). DESIGN:Subjects received treatment with CMSC or nCPAP each for 1 month in random order. The study was ana...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.125.1.118

    authors: Skinner MA,Kingshott RN,Jones DR,Taylor DR

    更新日期:2004-01-01 00:00:00