Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis.

Abstract:

:This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic acid, a beta-lactamase inhibitor, and amoxicillin has been shown bactericidal for M tuberculosis in vitro. These data suggest that resistant tuberculosis may warrant a trial of treatment including amoxicillin-clavulanic acid.

journal_name

Chest

journal_title

Chest

authors

Nadler JP,Berger J,Nord JA,Cofsky R,Saxena M

doi

10.1378/chest.99.4.1025

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

1025-6

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)48774-X

journal_volume

99

pub_type

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