Abstract:
:This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic acid, a beta-lactamase inhibitor, and amoxicillin has been shown bactericidal for M tuberculosis in vitro. These data suggest that resistant tuberculosis may warrant a trial of treatment including amoxicillin-clavulanic acid.
journal_name
Chestjournal_title
Chestauthors
Nadler JP,Berger J,Nord JA,Cofsky R,Saxena Mdoi
10.1378/chest.99.4.1025subject
Has Abstractpub_date
1991-04-01 00:00:00pages
1025-6issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)48774-Xjournal_volume
99pub_type
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