Abstract:
BACKGROUND:Increased outdoor air pollution levels are associated with more frequent use of rescue inhalers in subjects with asthma. However, it is unknown whether this phenomenon is explained by an air pollution-mediated increase in respiratory symptom severity or whether air pollutants decrease the efficacy of short-acting beta-agonists (SABAs). METHODS:We examined the relationship between the percentage change in FEV(1) after SABA use with outdoor air pollution exposure in 85 children with asthma who were 7 to 12 years of age. Outdoor air pollution exposure was determined by measuring nitrogen dioxide (NO(2)), ozone (O(3)), and fine particulate matter (ie, particulate matter with an aerodynamic diameter < 2.5 microm [PM(2.5)]) levels. These measurements were obtained from the Mexico City Automated Monitoring Network from network sites located within a 5-km radius of each child's home and school. RESULTS:We found that a same-day interquartile increase of 10 parts per billion (ppb) in NO(2) concentration was associated with a reduced response of FEV(1) to SABA therapy (-15%; 95% CI, -29 to -0.5). This association was also significant when considering NO(2) levels in each of the preceding 3 days. An interquartile O(3) increase (16 ppb) in the preceding fifth day was associated with a reduced response to SABA (-11%; 95% CI, -23 to -1); an interquartile PM(2.5) increase (14 microg/m(3)) was not associated with any significant reductions in the response to SABA therapy. These associations were not observed in children receiving therapy with inhaled corticosteroids. CONCLUSIONS:Our results suggest that recent exposure to NO(2) and possibly O(3) may reduce the response to SABAs in producing bronchodilation in children with asthma. The association between NO(2) and FEV(1) response to SABA administration may have important implications in understanding how outdoor air pollution levels relate to asthma control.
journal_name
Chestjournal_title
Chestauthors
Hernández-Cadena L,Holguin F,Barraza-Villarreal A,Del Río-Navarro BE,Sienra-Monge JJ,Romieu Idoi
10.1378/chest.08-1463subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1529-1536issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(09)60733-9journal_volume
136pub_type
杂志文章相关文献
CHEST文献大全abstract::Aspiration of a foreign body into the lower airways is a common occurrence and can cause significant morbidity and mortality in humans. Most foreign bodies of the tracheobronchial tree are inanimate. However, the medical literature includes reports of live foreign bodies in the airways. Fish, leeches, and roundworms a...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2016.10.041
更新日期:2017-02-01 00:00:00
abstract::We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.1.26
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Average volume-assured pressure support (AVAPS) has been introduced as a new additional mode for a bilevel pressure ventilation (BPV) device (BiPAP; Respironics; Murrysville, PA), but studies on the physiologic and clinical effects have not yet been performed. There is a particular need to better define the ...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.130.3.815
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Dynamic hyperinflation (DH) develops in patients with COPD during incremental exercise with a cycle ergometer. The aims of this study were to determine whether DH can be evidenced after walking with a handheld spirometer and to determine its functional consequences. METHODS:Fifty patients with COPD (39 men;...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-0410
更新日期:2009-12-01 00:00:00
abstract::Disabling presyncopal attacks were provoked in a patient with a sinus nodal disorder and cardiac pacemaker by treatment with antianginal vasodilators. At cardiac catheterization a severe fall in aortic pressure was documented during ventricular pacing, when desynchronized atrial contractions coincided with ventricular...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.6.919
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Malignant pleural effusion is associated with short life expectancy and significant morbidity. A randomized controlled trial comparing indwelling pleural catheters (IPCs) with talc pleurodesis found that IPCs reduced in-hospital time and the need for additional procedures but were associated with excess adve...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.13-2481
更新日期:2014-10-01 00:00:00
abstract::A case of double-orifice mitral valve in a 16-year-old Japanese boy is presented. Two-dimensional echocardiography, including transesophageal approach, showed two approximately equal orifices with three papillary muscles. Color Doppler echocardiography showed a mild mitral regurgitation from both orifices. No other ca...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.104.5.1616
更新日期:1993-11-01 00:00:00
abstract::A 40-year-old woman with lymphangiomatosis also had an intrathoracic lymphangioma infection. Since the age of 8 years, the patient had undergone repeated abdominal and mediastinal cyst surgeries and had received a diagnosis of lymphangiomatosis. At this time, she showed a high fever of 38.5°C. Cultures of both blood a...
journal_title:Chest
pub_type:
doi:10.1016/j.chest.2020.06.048
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:During medical procedures with the potential to produce aerosols such as bronchoscopy, intubation, or CPR, health-care workers (HCWs) may be exposed to infectious bioaerosols. This scenario is of particular concern when high consequence pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.07.026
更新日期:2020-12-01 00:00:00
abstract::In this investigation, we examined changes in exfoliated tracheobronchial cells in sputum in 46 individuals (mean age = 49.2 years; mean packyears = 48.7) who discontinued smoking and 37 individuals (mean age = 54.9 years; mean packyears = 65.2) who continued to smoke over a 12-month period after participation in the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.3.607
更新日期:1992-03-01 00:00:00
abstract::To further delineate indications for noninvasive pressure support ventilation (NIPSV), we proposed this noninvasive technique as an alternative to endotracheal intubation in 17 consecutive patients with acute respiratory failure from various causes. Eight patients (47 percent) were successfully ventilated with NIPSV, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.3.907
更新日期:1993-03-01 00:00:00
abstract::Breathing against positive expiratory pressure has been used to improve gas exchange in many forms of pulmonary edema, and forced expiration against resistance during exercise has been advocated for climbing at high altitude as a method to optimize performance. To evaluate the effect of expiratory positive airway pres...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.3.330
更新日期:1985-03-01 00:00:00
abstract::The inhibitory effect of lidocaine and lidocaine plus methylparaben as a preservative was studied with 25 strains of bacteria. The tested strains were mixed with each topical anesthetic preparation, and quantitative cultures were performed on aspirates at 0, 30, 60, and 120 minutes. Results were compared to counts obt...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.1.37
更新日期:1979-07-01 00:00:00
abstract::Sleep health is a multidimensional construct that includes adequate duration, quality, and appropriately timed sleep that may be influenced by environmental factors. In this review, we focus on how an individual's living and sleeping environment, both the surrounding neighborhood physical and social features and the a...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.12.002
更新日期:2020-05-01 00:00:00
abstract::Open-chest direct cardiac compression represents a more potent but highly invasive option for cardiac resuscitation when conventional techniques of closed-chest cardiac resuscitation fail after prolonged cardiac arrest. We postulated that venoarterial extracorporeal circulation might be a more effective intervention w...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1846
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to compare the safety, use, and cost profiles of open thoracotomy vs video-assisted thoracoscopic surgery (VATS) for wedge resection in lung cancer performed by thoracic surgeons in the United States. METHODS:The Premier database, which contains complete patient billing, hospi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-3013
更新日期:2012-02-01 00:00:00
abstract::Chronic pulmonary thromboembolism (CPE) is a challenging diagnosis for clinicians. It is an often-forgotten diagnosis and can be difficult to detect and easily misdiagnosed. The radiologic features on CT pulmonary angiography are subtle and can be further compounded by pathologic mimics and unusual findings observed w...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-1384
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:We evaluated the association between hemodynamic parameters of chronic congestive heart failure (CHF) and mediastinal lymphadenopathy (MLA) in heart transplantation (HT) candidates and the effect of HT on MLA. We also described the results of lymph node (LN) biopsies of MLA in the patients. METHODS:Patients...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1386
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To measure tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in pleural effusions caused by tuberculosis (TB) and malignancy and their relationship with plasminogen activator inhibitor type I (PAI-1) and tissue type plasminogen activator (tPA), and to compare the differences between tu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.5.1292
更新日期:1999-11-01 00:00:00
abstract:STUDY OBJECTIVE:To assess whether myocardial contrast echocardiography (MCE) using harmonic power Doppler (HPD) in conjunction with the transvenous contrast agent SHU 563A would be useful in detecting stunned but viable myocardium. DESIGN:Acute coronary occlusion (2 to 3 h) followed by 1 h of reperfusion was created i...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.2.567
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Lung cancer screening (LCS) is an important secondary prevention measure to reduce lung cancer mortality. The goal of this study was to assess state-level variations in LCS among the US elderly during the first 3 years since Medicare began its LCS reimbursement policy in 2015. METHODS:This ecological study ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.11.005
更新日期:2020-04-01 00:00:00
abstract::If we hope to repair damaged lung tissue associated with a variety of acquired and developmental diseases, we must first gain a full appreciation of normal lung development. As an approach, we have utilized Affymetrix (Santa Clara, CA) high-density, oligonucleotide-based microarrays to generate an expression profile o...
journal_title:Chest
pub_type:
doi:10.1378/chest.121.3_suppl.42s
更新日期:2002-03-01 00:00:00
abstract:STUDY OBJECTIVES:To investigate the roles of human alpha-defensin (HAD), human beta-defensin (HBD)-1, and HBD-2, novel antimicrobial peptides, in patients with Mycobacterium avium-intracellulare infection (MAI). PATIENTS:The study included 25 patients (10 men) with MAI who visited our hospital between June 1998 and Au...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.4.1131
更新日期:2001-04-01 00:00:00
abstract::The clinical spectrum of mitochondrial diseases has expanded dramatically in the last decade. Abnormalities of mitochondrial function are now thought to participate in a number of common adult diseases, ranging from exercise intolerance to aging. This review outlines the common presentations of mitochondrial disease i...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.120.2.634
更新日期:2001-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the role of quantitative cultures of BAL for diagnosing nosocomial pneumonia in mechanically ventilated patients. DESIGN:Cohort study. SETTING:Medical ICU, Hôpital Bichat, Paris, France, an academic tertiary care center. PATIENTS:A total of 141 episodes of suspected lung infection in 84 c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.2.411
更新日期:1997-02-01 00:00:00
abstract::While the outcome of in-hospital cardiopulmonary arrest has been studied extensively, the clinical antecedents of arrest are less well defined. We studied a group of consecutive general hospital ward patients developing cardiopulmonary arrest. Prospectively determined definitions of underlying pathophysiology, severit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.6.1388
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of physician-diagnosed COPD and to explore the relationship between the total amount of cigarettes smoked (TACS) and COPD among urban and rural adults in Nanjing, China. DESIGN:Population-based, cross-sectional study conducted between October 2000 and March 2001. SETTING:Admin...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.4.2818
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To assess whether the presence and duration of air leaks after lobectomy are associated with an increased incidence of cardiopulmonary complications. METHODS:Propensity score analysis was used on 726 patients undergoing pulmonary lobectomy from 1995 through 2004 to form three well-matched pairs of patients: pa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.4.1150
更新日期:2006-10-01 00:00:00
abstract::Several reports have implicated pregnancy as a cause of deterioration in patients with pulmonary arteriovenous fistulas. We report a 27-year-old woman with multiple pulmonary arteriovenous fistulas who required coil spring embolotherapy in her 24th week of pregnancy due to a spontaneous hemothorax and hypoxemia. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.6.1522
更新日期:1990-12-01 00:00:00
abstract::We tested the response characteristics of a dual transcutaneous (tc) PO2/PCO2 monitoring system in healthy subjects who breathed various gas mixtures, and we compared steady-state tc readings to simultaneous arterial blood gas analysis in 20 stable respiratory outpatients. The electrodes were simple to apply, required...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.5.1211
更新日期:1991-05-01 00:00:00