Abstract:
BACKGROUND:Traditional diagnostic tests for pericardial tuberculosis (TB) are insensitive and often require long culture periods, and this has led to more emphasis being placed on biochemical tests such as the pericardial adenosine deaminase (ADA) test. However, controversy exists as to its diagnostic utility. In addition, the use of interferon (IFN)-gamma, which is a reliable indicator of pleural and peritoneal TB, has not been explored in pericardial effusions. We investigated ADA and IFN-gamma levels in pericardial effusions of different etiologies. METHODS AND RESULTS:A prospective study was carried out from February 1995 to February 1998 at Tygerberg Hospital (South Africa), with pericardial taps being performed under echocardiographic guidance. During this period, 110 consecutive patients presenting with large pericardial effusions were included in the study. Diagnoses were made according to predetermined criteria, and they included TB (n = 64), malignancy (n = 12), nontuberculous infections (n = 5), other effusions (n = 19), and effusions of uncertain origin (n = 10). The median ADA level in the tuberculous group was 71.7 U/L (range, 10.3 to 303.6 U/L), which was significantly higher than that in any other group (p < 0.05). With a cutoff level for ADA activity of 30 U/L, sensitivity was 94%, specificity was 68%, and positive predictive value was 80%. IFN-gamma levels were determined in 30 subjects. The median IFN-gamma concentration in the tuberculous group was > 1,000 pg/L, which was significantly higher than in any other diagnostic group (p < 0.0005). A cutoff value of 200 pg/L for IFN-gamma resulted in a sensitivity and specificity of 100% for the diagnosis of pericardial TB. CONCLUSION:Pericardial fluid levels of ADA and IFN-gamma are useful in the diagnosis of tuberculous pericarditis.
journal_name
Chestjournal_title
Chestauthors
Burgess LJ,Reuter H,Carstens ME,Taljaard JJ,Doubell AFdoi
10.1378/chest.122.3.900subject
Has Abstractpub_date
2002-09-01 00:00:00pages
900-5issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)47185-0journal_volume
122pub_type
杂志文章相关文献
CHEST文献大全abstract:STUDY OBJECTIVES:To assess the consequences of nitrate withdrawal in angina-free and hemodynamically stable coronary patients. DESIGN:Prospective, open, intervention study. SETTING:Cardiology outpatient clinic of a university-affiliated municipal hospital. PATIENTS:Angina-free patients who were hemodynamically stabl...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0012-3692(15)33392-4
更新日期:2003-11-01 00:00:00
abstract:AIMS:This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed wheth...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-1263
更新日期:2007-07-01 00:00:00
abstract::We evaluated two patients with systemic cholesterol embolization (SCE) associated with the development of pleural effusions. These two patients had evidence of atherosclerosis and presented with livedo reticularis, renal insufficiency, and gangrenous cutaneous changes as manifestations of their SCE. In both cases, clo...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.103.3.792
更新日期:1993-03-01 00:00:00
abstract::Burnout syndrome is an increasingly common phenomenon that threatens our critical care workforce and the well-being of its members. Burnout syndrome can be conceived of as a workforce manifestation of chronic workload and workforce capacity imbalance. This study explores the role of workload management tools that can ...
journal_title:Chest
pub_type: 评论,杂志文章,评审
doi:10.1016/j.chest.2019.04.103
更新日期:2019-11-01 00:00:00
abstract:CASE PRESENTATION:A 32-year-old Nigerian woman, who became pregnant after undergoing in vitro fertilization, was admitted with nausea and abdominal pain. She had a history of two miscarriages and infertility because of tubal blockage treated by salpingectomy. One week prior, she presented to an outside hospital with pr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.10.001
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The objective of this study was to systematically review and quantitatively synthesize all randomized controlled trials (RCTs), comparing important outcomes in ventilated critically ill patients who received an early or late tracheotomy. METHODS:A systematic literature search of PubMed, Cumulative Index to ...
journal_title:Chest
pub_type: 杂志文章,meta分析,评审
doi:10.1378/chest.11-2024
更新日期:2011-12-01 00:00:00
abstract::Thirty-three patients with T3,N2,M0 or T4,N2,M0, non-small-cell lung cancer (NSCLC) took part in a phase 2 study in an attempt to evaluate the feasability of neoadjuvant chemotherapy followed by surgery and thoracic radiotherapy. Chemotherapy consisted of daily administration of the following treatment: etoposide, 100...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.106.5.1451
更新日期:1994-11-01 00:00:00
abstract::We have assessed right and left ventricular function by multigated radionuclide ventriculography in 12 consecutive patients with acquired immunodeficiency syndrome (AIDS) grouped according to the CDC classification system for HIV infection. Results were correlated with clinical, electrocardiographic and echocardiograp...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.592
更新日期:1988-03-01 00:00:00
abstract::Patients with HES and pulmonary infiltrates may pose certain diagnostic problems as the infiltrates may be attributed to infection, infarction, congestive heart failure, or HES itself. We report an 87-year-old woman with idiopathic HES presenting with bibasal alveolar infiltrates. Differential cell count in BAL fluid ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1178
更新日期:1992-04-01 00:00:00
abstract:STUDY OBJECTIVE:s: Patients with rheumatoid arthritis (RA) have a high prevalence of pulmonary function test (PFT) abnormality, but the long-term significance of this is unknown. We performed a longitudinal study of pulmonary function in asymptomatic, nonsmoking patients with active RA requiring disease-modifying drugs...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.4.1224
更新日期:2003-10-01 00:00:00
abstract::Prosthetic valve endocarditis is a formidable complication following cardiac valve replacement. Surgical intervention has resulted in a significant reduction in mortality when certain complications prevail. We report two such cases of prosthetic valve endocarditis in which the use of transesophageal echocardiography p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1886
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:We evaluated the association between hemodynamic parameters of chronic congestive heart failure (CHF) and mediastinal lymphadenopathy (MLA) in heart transplantation (HT) candidates and the effect of HT on MLA. We also described the results of lymph node (LN) biopsies of MLA in the patients. METHODS:Patients...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1386
更新日期:2011-06-01 00:00:00
abstract::We report three cases of pulmonary edema associated with hyperbaric oxygen therapy, including one fatality. All three patients had cardiac disease and reduced left ventricular (LV) ejection fractions (EFs). Two patients had diabetes, and one patient had severe aortic stenosis. Hyperbaric oxygen therapy may contribute ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.4.1407
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Electromagnetic navigation bronchoscopy (ENB) with biopsy under fluoroscopic guidance has enhanced the yield of flexible bronchoscopy in the diagnosis of peripheral lung lesions. However, the accuracy of ENB navigation suggests that the addition of fluoroscopy is redundant. OBJECTIVES:Data were prospectivel...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.06-3016
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Pathogenic bacteria colonize the airways of 30% to 40% of patients with COPD and cause approximately 50% of exacerbations. New strains of nontypeable Haemophilus influenzae (NTHI) and Moraxella catarrhalis are associated with exacerbations. Antimicrobial protein/peptides (AMPs) play important roles in innate...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-2760
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. This study hypothesized that elevated plasma mtDNA is associated with ARD...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.09.028
更新日期:2020-01-01 00:00:00
abstract::The relationship between coffee consumption and the prevalence of bronchial asthma has been evaluated using data from the 1983 Italian National Health Survey, based on 72,284 individuals aged over 15 years randomly selected within strata of geographic area, size of the place of residence and of the household in order ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.2.386
更新日期:1988-08-01 00:00:00
abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.3.649
更新日期:1999-03-01 00:00:00
abstract::This report describes a 25-year follow-up of angiographically proven bilateral functioning Vineberg grafts. This represents the longest angiographic follow-up found in the literature. The relevance of these grafts in present-day revascularization procedures is discussed. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.3.824
更新日期:1997-03-01 00:00:00
abstract::Natural killer-cell activity of fresh interstitial pulmonary cell populations from patients with squamous cell and adenocarcinoma of the lung and carcinoma metastatic to the lung was assessed and compared to that of apparently normal lung. No increase in the percentage of lymphoid cell populations was noted in the int...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.26
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Lung expansion techniques (LETs) are widely used to prevent postoperative pulmonary complications (PPCs). However, the effects of each of these techniques on thoracoabdominal mechanics and PPC incidence after abdominal surgery remain unclear. The objective of this study was to compare the effects of LET on pu...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.14-2696
更新日期:2015-10-01 00:00:00
abstract::The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.5.779
更新日期:1986-11-01 00:00:00
abstract:STUDY OBJECTIVE:Bronchioloalveolar carcinoma (BAC) is an uncommon pulmonary neoplasm with various radiologic and clinical presentations. In this article, we analyze the initial radiologic findings, TNM stagings, surgical types, and radiologic features of recurrence, and correlate them with patient survival. DESIGN:A r...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.4.940
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:There is increasing support for the use of noninvasive positive pressure ventilation (NPPV) in the treatment of patients with acute respiratory failure. Highest success rates are recorded in patients with exacerbation of COPD, particularly in patients presenting primarily with hypercarbic respiratory failure...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.1.173
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:No studies have attempted to examine the genetic influence on the habit of snoring. The aim of the present study was to examine whether an association existed between self-reported snoring and family history of snoring and a number of genetic markers. MATERIAL AND METHODS:The data were derived from a primar...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.5.1289
更新日期:1995-05-01 00:00:00
abstract::Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinica...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.07.028
更新日期:2019-01-01 00:00:00
abstract::Pulmonary hypertension is a common finding in patients with idiopathic pulmonary fibrosis (IPF), and is associated with increased morbidity and mortality. Therapy with sildenafil has been shown to decrease pulmonary vascular resistance in patients with pulmonary fibrosis and may improve functional status. Patients wit...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.06-2101
更新日期:2007-03-01 00:00:00
abstract::While the outcome of in-hospital cardiopulmonary arrest has been studied extensively, the clinical antecedents of arrest are less well defined. We studied a group of consecutive general hospital ward patients developing cardiopulmonary arrest. Prospectively determined definitions of underlying pathophysiology, severit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.6.1388
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has severely affected ICUs and critical care health-care providers (HCPs) worldwide. RESEARCH QUESTION:How do regional differences and perceived lack of ICU resources affect critical care resource use and the well-being of HCPs? STUDY DESIGN AND METHODS:Betw...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.09.070
更新日期:2020-09-11 00:00:00
abstract::A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual asso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1.111
更新日期:1980-07-01 00:00:00