Abstract:
BACKGROUND:No studies have attempted to examine the genetic influence on the habit of snoring. The aim of the present study was to examine whether an association existed between self-reported snoring and family history of snoring and a number of genetic markers. MATERIAL AND METHODS:The data were derived from a primarily cardiovascular disease cohort study of 3,387 men aged 54 to 74 years. A number of sleep-related questions were included. Some 3,308 men had given valid questionnaire information on snoring and whether they had their own bedroom due to snoring and were regarded eligible for the present study. Men who reported that they snored often or always were considered habitual snorers, and those who reported that they seldom or never snored were considered nonsnorers. We considered habitual snorers who reported that they had their own bedroom due to snoring to be a group with a presumably more severe form of snoring. Information about other health and lifestyle parameters was obtained from a comprehensive questionnaire. Four major blood groups were determined: ABO, Rhesus, MNS, and Lewis, together with complement C3. A saliva sample was taken for determination of ABH secretor status. RESULTS:There was a strong relationship between habitual snoring and family history of snoring among grandparents, parents, siblings, and children. Odds ratios were from 2.4 to 4.2, and all associations were significant (p < 0.05). In multivariable analysis, the factor which most strongly separated habitual snorers from nonsnorers, was self-reported habitual snoring among family members. Looking at habitual snorers only, the factors most strongly separating those with their own bedroom due to snoring from those without, were the Lewis blood group phenotype, Le(a+b-) (29.6 vs 18.8%; p < 0.001; age, 63.4 vs 62.1 years; p < 0.01), and selfreported family history of habitual snoring (35.2 vs 29.0%; p < 0.05). CONCLUSION:There was an overall strong association between habitual snoring and family history of snoring. Among habitual snorers, two genetic markers and age, were the only factors that separated men who had their own bedroom due to snoring from others. The results of this study indicate that snoring, to some extent, is hereditary.
journal_name
Chestjournal_title
Chestauthors
Jennum P,Hein HO,Suadicani P,Sørensen H,Gyntelberg Fdoi
10.1378/chest.107.5.1289subject
Has Abstractpub_date
1995-05-01 00:00:00pages
1289-93issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)38194-6journal_volume
107pub_type
杂志文章相关文献
CHEST文献大全abstract::We report three cases of pulmonary edema associated with hyperbaric oxygen therapy, including one fatality. All three patients had cardiac disease and reduced left ventricular (LV) ejection fractions (EFs). Two patients had diabetes, and one patient had severe aortic stenosis. Hyperbaric oxygen therapy may contribute ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.120.4.1407
更新日期:2001-10-01 00:00:00
abstract::An unusual site and cause of disabling inspiratory and expiratory airflow limitation mimicking fixed upper airway obstruction is reported in two patients with sarcoidosis who had stenosis of almost the entire lengths of both main bronchi. The observed flows were consistent with a cross sectional airway diameter of 3 m...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.2.244
更新日期:1985-08-01 00:00:00
abstract::Respondents at an interactive symposium on pleural space infections (n = 339) at the 1991 American College of Chest Physicians Annual Scientific Assembly recorded their personal management preferences for hypothetical patients with empyema. The group's preference was to treat pleural sepsis from an anaerobic multilocu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.1.259
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::The effect of interstitial pulmonary fibrosis on pregnancy is unclear. We present the findings in a 31-year-old woman with severe pulmonary fibrosis (vital capacity, 37 percent of predicted) secondary to hard metal disease who went through a successful term pregnancy. The patient was a grinder of tungsten-carbide dril...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.663
更新日期:1988-03-01 00:00:00
abstract::Nodular opacities are a well-known pulmonary manifestation of rheumatoid arthritis (RA), occurring most often in seropositive men who smoke and have subcutaneous nodules. In the past 15 years two cases of lung carcinoma presenting as pulmonary nodules have been reported in patients with rheumatoid disease. We present ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.5.1022
更新日期:1989-11-01 00:00:00
abstract::The most examined tumor markers in lung cancer patients are CEA, hormonal peptides, and some neurogenic enzymes in small cell carcinoma. Calcitonin, ACTH, ADH, CEA, neurophysin, oxytocin, beta-endorphin, neuron-specific enolase, and CK BB are elevated in serum specimens in 25-75% of cases of small cell carcinoma. The ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.89.4_supplement.219s
更新日期:1986-04-01 00:00:00
abstract::The clinical effect of inhaled radio-labeled (Technetium-99m diethylenetriamine-pentaacetic acid) methacholine was studied in two separate experiments performed in eight symptom-free asthmatics with bronchial hyperresponsiveness. Aerosols were formed by two different nebulizers, producing either mainly small aerosol p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.6.1781
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Lung cancer screening, despite its proven mortality benefit, remains vastly underutilized. Previous studies examined knowledge, attitudes, and beliefs to better understand the reasons underlying the low screening rates. These investigations may have limited generalizability because of traditional participant...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.12.048
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:C-reactive protein (CRP) has been well recognized as a strong independent predictor of short-term and long-term mortality after non-ST-segment elevation acute coronary syndromes. However, limited studies have been conducted correlating CRP levels within 6 h following the onset of ST-segment elevation (ST-se)...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.3.803
更新日期:2005-03-01 00:00:00
abstract:STUDY OBJECTIVES:To validate capnometric recirculating gas tonometry (CRGT) for continuously monitoring gut intramucosal PCO2 (PiCO2) in a septic shock model, and to compare gastric vs esophageal PCO2 vs intramucosal-arterial PCO2 gradients. INTERVENTIONS:CRTG catheters were placed in the stomach and esophagus of six ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.4.1078
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has severely affected ICUs and critical care health-care providers (HCPs) worldwide. RESEARCH QUESTION:How do regional differences and perceived lack of ICU resources affect critical care resource use and the well-being of HCPs? STUDY DESIGN AND METHODS:Betw...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.09.070
更新日期:2020-09-11 00:00:00
abstract::We report the findings in two patients with sulfasalazine-induced pulmonary disease. The first patient developed pulmonary interstitial fibrosis after more than 4 yr of treatment for Crohn's disease. Pulmonary symptoms and chest roentgenographic and pulmonary function abnormalities gradually reversed after stopping th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1033
更新日期:1992-04-01 00:00:00
abstract::To evaluate whether the response of left ventricular pump function during low-level exercise in the early postinfarction period can anticipate its change during the first year after acute myocardial infarction (MI), global and regional ejection fractions (EF) were investigated using radionuclide angiography in 52 cons...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.335
更新日期:1992-08-01 00:00:00
abstract::The long-term pulmonary consequences of right middle lobe syndrome (RMLS) in childhood are not known. Therefore, outcome was evaluated in 17 children with RMLS diagnosed in early childhood (mean age, 3.3 years; SD, 1.1 year). Mean age at follow-up was 10.1 years (SD, 2.6 years). RMLS was defined as atelectasis of the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.150
更新日期:1995-07-01 00:00:00
abstract::The role of lymphocytes in the pathogenesis of amiodarone-induced lung disease is controversial. Increases in the percentages of lymphocytes in bronchoalveolar fluid of both patients and animals with amiodarone pulmonary toxicity have been reported. To assess whether these lymphocytes are functionally activated, we me...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.230
更新日期:1991-01-01 00:00:00
abstract::This study describes the extent of agreement in classification of chest radiographs using the International Labor Organization (ILO) classification among six readers from the United States and Canada. A set of 119 radiographs was created and read by three Canadian and three US readers. The two ratings of interest were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.6.1740
更新日期:1998-12-01 00:00:00
abstract::Fourteen of 22 patients (64%) with normally functioning porcine prosthetic valves in the mitral position had apical diastolic rumbles on phonocardiogram and by auscultation. Six (27%) had opening snaps. Factors necessary for the production of a diastolic rumble appear to include central flow, a flexible stent, and the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.2.189
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2096
更新日期:2015-04-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if screening by specialists could reduce unnecessary test ordering and reduce costs related to diagnostic workup in patients undergoing evaluation for tuberculosis. DESIGN:Prospective evaluation of expert opinion in consecutive patients suspected of having tuberculosis. SETTING:A large mu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.3.681
更新日期:1998-09-01 00:00:00
abstract::We analyzed seven patients with beta-thalassemia intermedia presenting with congestive heart failure secondary to pulmonary hypertension. This condition has been recognized only recently as part of the clinical spectrum of beta-thalassemia. Our group of patients included two men and five women with the clinical pictur...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.1.50
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of noninvasive positive pressure ventilation (NPPV) by helmet and face mask in immunocompromised patients with hypoxemic acute respiratory failure (ARF). DESIGN:Case-control study. SETTING:The general ICU of a university hospital. PATIENTS:Nineteen immunocompromised patients (hemato...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.5.1508
更新日期:2004-11-01 00:00:00
abstract::Disputes regarding life-prolonging treatments are stressful for all parties involved. These disagreements are appropriately almost always resolved with intensive communication and negotiation. Those rare cases that are not require a resolution process that ensures fairness and due process. We describe three recent cas...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2016.05.026
更新日期:2016-09-01 00:00:00
abstract::To assess the left ventricular function during sustained stable ventricular tachycardia (VT), ten patients, aged 58 to 74, underwent simultaneous echo-Doppler and hemodynamic studies during sinus rhythm and induced sustained stable monomorphic VT. The VT cycle length was 447 +/- 92 ms (mean +/- SD). During VT, cardiac...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.275
更新日期:1989-08-01 00:00:00
abstract::A man with primary lung cancer developed respiratory failure due to lymphangitis carcinomatosis that was diagnosed by transbronchial lung biopsy specimen. After combination chemotherapy with high-dose etoposide and cisplatin (CDDP), he was able to cease oxygen therapy and showed improvement of his lymphangitis carcino...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.3.967
更新日期:1993-03-01 00:00:00
abstract::A mechanical model was employed to examine phase and amplitude relationships between simulated pleural and mouth pressures during panting at different frequencies with and without lower airway obstruction and with rigid or flaccid extrathoracic airways. Results confirm the hypothesis that, in the presence of lower air...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.4.589
更新日期:1984-10-01 00:00:00
abstract::Twenty-one patients with malignant pleural effusion (MPE) were prospectively entered into a nonrandomized, single-armed study to evaluate the efficacy and safety of recombinant interferon (IFN) alpha-2b (INTRON A; Schering-Plough; Kenilworth, NJ) as an intrapleural palliative agent. From March 1989 through February 19...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.111.6.1597
更新日期:1997-06-01 00:00:00
abstract::To assess the role of open lung biopsy in patients with the acquired immunodeficiency syndrome (AIDS), we retrospectively reviewed the cases of 42 patients with AIDS who underwent this procedure for the diagnosis of pulmonary infiltrates. Four patients had no preceding bronchoscopy because the severity of the respirat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.5.659
更新日期:1987-05-01 00:00:00
abstract:BACKGROUND:Recent study of the inflammatory reactions occurring during and after cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the inflammatory cascade in perioperative injury. However, the exact mechanisms of this complex response remain to be fully determined. METHODS:Literature o...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.112.3.676
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. Our objective was to investigate the effect of BPA on respiratory function. METHODS:We enrolled patients with inop...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.10.002
更新日期:2017-03-01 00:00:00