Abstract:
STUDY OBJECTIVES:To assess the consequences of nitrate withdrawal in angina-free and hemodynamically stable coronary patients. DESIGN:Prospective, open, intervention study. SETTING:Cardiology outpatient clinic of a university-affiliated municipal hospital. PATIENTS:Angina-free patients who were hemodynamically stable for at least 3 months before study onset were enrolled. They were all regularly receiving nitrates for symptom control. Those with significant reasons to avoid stopping nitrates, such as heart failure (ejection fraction <35%) or high BP (> 160 mm Hg systolic and/or > 100 mm Hg diastolic), and noncompliant patients were excluded. INTERVENTIONS:After providing informed consent and undergoing an exercise test (whenever possible), the participants were randomized to abruptly discontinue (study group) or continue (control group) nitrate treatment. Follow-up continued for at least 3 months after study entry. MEASUREMENTS AND RESULTS:Eighty patients were randomized to the study group and 40 patients to the control group (mean age [+/- 1 SD], 65.5 +/- 11 years and 66.1 +/- 10.9 years, respectively; p = not significant). The first month, eight study patients (10%) had a recurrence of anginal symptoms, compared with one control subject (2.5%) [p = not significant]. All eight patients responded promptly and favorably to the resumption of nitrate administration. CONCLUSIONS:Nitrate administration can be safely discontinued in angina-free and hemodynamically stable coronary patients who receive this medication on a regular basis. If relapse of anginal symptoms occurs, it will be within 1 month following nitrate withdrawal, and will resolve satisfactorily with reinstatement of treatment.
journal_name
Chestjournal_title
Chestauthors
George J,Kitzis I,Zandorf D,Golovner M,Shapira I,Laniado S,Roth Adoi
10.1016/s0012-3692(15)33392-4subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1652-7issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)33392-4journal_volume
124pub_type
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