Hemodynamic effects of epoprostenol in patients with systemic sclerosis and pulmonary hypertension.

Abstract:

STUDY OBJECTIVES:To determine the cause of pulmonary hypertension (PH) in systemic sclerosis (SSc) patients since PH can occur because of pulmonary arteriopathy, pulmonary parenchymal destruction, and left ventricular cardiac dysfunction. DESIGN AND SETTING:Consecutive case series in a university hospital. PATIENTS:Nine SSc patients with PH (mean pulmonary artery pressure, 41 mm Hg), with (n = 6) or without (n = 3) concomitant interstitial lung disease (ILD). METHODS:Acute infusion of epoprostenol was begun at 2 ng/kg/min and was titrated upward at a rate of 2 ng/kg/min every 30 min until symptomatic complications developed or pulmonary artery vascular resistance (PVR) was reduced by 50%. RESULTS:Eight of nine patients demonstrated a reduction of > or = 20% in PVR, suggesting that vasoreactivity is common despite the presence of significant ILD. A single patient had no response to infusion with unchanged hemodynamics and oxygenation. One patient developed hypoxemia as cardiac output increased, suggesting a worsening of ventilation/perfusion matching or the presence of an anatomic shunt. Acute pulmonary edema developed in one patient at an infusion rate of 6 ng/kg/min. The results of cardiac catheterization suggested that pulmonary edema was caused by SSc heart disease. CONCLUSION:SSc patients with ILD have diverse and sometimes multiple causes of PH that can be determined by short-term epoprostenol infusion. Beneficial effects can be obtained from epoprostenol despite extensive ILD.

journal_name

Chest

journal_title

Chest

authors

Strange C,Bolster M,Mazur J,Taylor M,Gossage JR,Silver R

doi

10.1378/chest.118.4.1077

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

1077-82

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37710-2

journal_volume

118

pub_type

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