Abstract:
:Epidemiologic research has revealed a substantial portion of the general population with abnormal spirometry results that are characterized by decreased FEV1 and FVC but a preserved FEV1/FVC ratio. This restrictive spirometry pattern (RSP) is inconsistently defined in the literature and not well addressed by current guidelines; there is an accumulating body of evidence, however, that RSP is prevalent to a similar degree as airflow obstruction. Genetic and other risk factors for RSP, such as inhalational injuries and early life exposures, continue to be actively described. Although it seems that RSP is closely associated with the metabolic syndrome, diabetes, and systemic inflammation, it is not a simple marker of obesity. RSP is associated with adverse cardiovascular outcomes, as well as mortality, and it may be an underappreciated cause of functional impairments and respiratory symptoms. Improvement in outcomes in this population will require that clinicians have an appreciation for the significance of this spirometry pattern; additional research into the clinical and radiologic phenotype of these subjects is also needed. This article provides an overview of the recent developments in our understanding of this prevalent and highly morbid spirometry pattern.
journal_name
Chestjournal_title
Chestauthors
Godfrey MS,Jankowich MDdoi
10.1378/chest.15-1045subject
Has Abstractpub_date
2016-01-01 00:00:00pages
238-51issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(15)00010-0journal_volume
149pub_type
杂志文章,评审相关文献
CHEST文献大全abstract::A 10-year-old, 36-kg child with a malignant air leak who failed conventional mechanical ventilation and high-frequency jet ventilation was successfully treated with a neonatal high-frequency oscillatory ventilator for 31 days. Since the air leak resolved with minimal hemodynamic compromise, this technique may have app...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.1.263
更新日期:1991-07-01 00:00:00
abstract::Cardiovascular complications from cocaine use have been recognized in increasing frequency in recent years. We report the case of a young man with a history of intranasal cocaine use presenting with acute congestive heart failure who, on postmortem examination, was found to have idiopathic hemochromatosis. It is specu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.2.374
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:COPD is characterized by chronic airflow limitation and inflammation of the respiratory tract. Several inflammatory biomarkers have been evaluated in COPD but are poorly related to disease severity and progression. Osteoprotegerin (OPG) is a glycoprotein mediator that is expressed in the lung and macrophages...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1608
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:The antisynthetase syndrome consists of interstitial lung disease (ILD), arthritis, myositis, fever, mechanic's hands, and Raynaud phenomenon in the presence of an antisynthetase autoantibody, most commonly anti-Jo-1. It is believed that all the antisynthetases are associated with a similar clinical profile,...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-2233
更新日期:2009-06-01 00:00:00
abstract::Adults with CF followed in a university center were assessed for the presence of the most common CF gene mutation, delta-F508. Excluding one member of a sibling pair, 29 of 55 subjects had two copies of delta-F508 (homozygotes), 23 had one copy of delta-F508 with the other CF mutation not identified (complex heterozyg...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.506
更新日期:1992-08-01 00:00:00
abstract::Forty-three consecutive patients requiring endotracheal intubation in an emergency room were studied prospectively to define the complications associated with intubation and the survival of these patients, and to evaluate emergency room policies. The indications for intubation were acute respiratory failure (ARF) in 2...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.5.541
更新日期:1979-05-01 00:00:00
abstract::Numerous alterations in the sympathetic nervous system have been reported in patients with obstructive sleep apnea. It is unclear whether such alterations can be attributed to the respiratory disturbance itself, the resulting hypoxia, or disruption of sleep. We examined urinary norepinephrine levels in 45 individuals ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.3.639
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited response to currently available therapies. Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury. However, in IPF, ATII cells die and are replace...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.03.021
更新日期:2016-09-01 00:00:00
abstract::Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; sh...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.07-1496
更新日期:2008-01-01 00:00:00
abstract::A 32-year-old man who presented with symptoms suggesting empyema was found at thoracotomy to have infarction of an extralobar pulmonary sequestration. He was completely relieved by excision of the sequestration after securing the systemic vascular pedicle which had undergone torsion. Recognition of the anomalous blood...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.68.1.98
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND:Among patients hospitalized for community-acquired pneumonia (CAP), the risk factors for short-term hospital readmission after discharge are unknown. METHODS:We conducted a prospective observational study of 1,117 patients who had been discharged alive after hospitalization for CAP. We collected variables a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2950
更新日期:2009-10-01 00:00:00
abstract::A group of 14 patients with mitral valve prolapse syndrome was referred for coronary angiographic study. The group was selected on the basis that all members had recurrent chest pain as their chief complaint and all had interpreted their chest pain as serious enough to warrant at lest two previous emergency visits to ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.4.449
更新日期:1981-04-01 00:00:00
abstract::Patients with HES and pulmonary infiltrates may pose certain diagnostic problems as the infiltrates may be attributed to infection, infarction, congestive heart failure, or HES itself. We report an 87-year-old woman with idiopathic HES presenting with bibasal alveolar infiltrates. Differential cell count in BAL fluid ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1178
更新日期:1992-04-01 00:00:00
abstract::Intrathoracic goiter is a rare cause of superior vena cava syndrome. We present the findings in a patient in whom the syndrome was precipitated by therapy with propylthiouracil and remitted on withdrawal of the medication. The superior vena cava syndrome did not recur on medical management, suggesting that surgery is ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.3.356
更新日期:1981-03-01 00:00:00
abstract::There is now a new pathway and examination for sleep medicine, sponsored by the American Board of Internal Medicine, and a number of accredited sleep medicine fellowship programs through the Accreditation Council for Graduate Medical Education. This review takes an historical approach to discuss the process of educati...
journal_title:Chest
pub_type: 历史文章,杂志文章,评审
doi:10.1378/chest.10-0783
更新日期:2011-05-01 00:00:00
abstract:STUDY OBJECTIVES:Quadriceps fatigue can occur in patients with COPD after exhaustive cycle exercise. The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects. SUBJECTS:Nine male patients with COPD with a...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.123.4.1104
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.05.011
更新日期:2017-11-01 00:00:00
abstract::Intravenous dipyridamole thallium imaging is reported to be a safe test with minimal side effects. It has been proposed by some that the test simply dilates the coronary vessels without actually producing myocardial ischemia. In this report, we describe a patient who, following intravenous dipyridamole thallium imagin...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.6.1102
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:In the current economic climate, hospitals and academic institutions demand that medical departments function in an efficient and cost-effective manner. Detailed business plans are necessary to build new clinical programs, and institutions have learned that new programs are associated with significant costs ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.4.1382
更新日期:2005-04-01 00:00:00
abstract::To evaluate the incidence, pattern and clinical importance of endotoxemia in septic shock, frequent, serial endotoxin determinations were made prospectively in patients with shock. Detectable endotoxin occurred in 43 of 100 patients with septic shock, but in only one of ten patients with shock due to nonseptic causes....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.169
更新日期:1991-01-01 00:00:00
abstract:STUDY OBJECTIVES:Prior to the availability of the oral endothelin antagonist bosentan, most patients with pulmonary arterial hypertension (PAH) were treated with continuously infused prostacyclins. Many patients receiving prostacyclins would have received bosentan if it had been available at the time of their diagnosis...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.3.808
更新日期:2004-09-01 00:00:00
abstract::OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction du...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.03.001
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and significance of pericardial abnormalities in systemic sclerosis (SSc)-related interstitial lung disease (ILD). METHODS:Retrospective study of 41 subjects with SSc-related ILD who underwent evaluation including thoracic high-resolution CT (HRCT) imaging, transthoracic echocard...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2317
更新日期:2007-04-01 00:00:00
abstract::The reactive airway dysfunction syndrome (RADS) is a recently described syndrome in which bronchial hyperreactivity and asthmatic symptoms develop in previously healthy individuals after a single large exposure to an irritating gas, fume, or vapor. We report a cluster of three Philadelphia police officers who develope...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.4.928
更新日期:1990-10-01 00:00:00
abstract:STUDY OBJECTIVES:The primary objective was to determine whether high-dose formoterol, 24 mug bid, was associated with more asthma exacerbations compared with lower formoterol doses in patients with stable persistent asthma. Serious asthma exacerbations (life threatening or requiring hospitalization) were the primary en...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.129.1.27
更新日期:2006-01-01 00:00:00
abstract::99mTechnetium stannous pyrophosphate has been shown to accumulate in acutely infarcted myocardium. To determine if the isotope is also taken up by severely ischemic, but not necrotic myocardium, we performed myocardial scintigraphic studies in 17 patients with chest pains. Seven of the patients satisfied conventional ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.2.168
更新日期:1976-02-01 00:00:00
abstract:OBJECTIVE:To describe the clinical correlates of asthma in a community-based sample of elderly persons. PARTICIPANTS:A community sample of 4,581 persons > or = 65 years old from the Cardiovascular Health Study. MEASUREMENTS:Standardized respiratory, sleep, and quality-of-life (QOL) questions, a medication inventory, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.116.3.603
更新日期:1999-09-01 00:00:00
abstract::COPD and OSA are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of coexisting OSA in that the increased lung volumes and low BMI associated with...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.04.160
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To formulate recommendations for the development of early intensive care unit (ICU) discharge criteria for low-risk monitor patients. DESIGN:Literature review of published reports over the period 1966 to 1991 pertaining to ICU discharge criteria. PATIENTS:Studies identifying patients admitted to ICUs who co...
journal_title:Chest
pub_type: 指南,杂志文章
doi:10.1378/chest.104.6.1812
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Failure to reliably diagnose ARDS may be a major driver of negative clinical trials and underrecognition and treatment in clinical practice. We sought to examine the interobserver reliability of the Berlin ARDS definition and examine strategies for improving the reliability of ARDS diagnosis. METHODS:Two hu...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.11.037
更新日期:2018-02-01 00:00:00