Sympathetic nervous system alterations in sleep apnea. The relative importance of respiratory disturbance, hypoxia, and sleep quality.

Abstract:

:Numerous alterations in the sympathetic nervous system have been reported in patients with obstructive sleep apnea. It is unclear whether such alterations can be attributed to the respiratory disturbance itself, the resulting hypoxia, or disruption of sleep. We examined urinary norepinephrine levels in 45 individuals with varying amounts of respiratory disturbance and sleep disruption. All were of similar age (40 to 60 years) and body weight (100 to 160% ideal body weight), and all were free from antihypertensive medications that could influence norepinephrine levels. Twenty-four-hour urinary norepinephrine levels were correlated with respiratory disturbance index (r = 0.39, p < 0.01) and mean oxygen saturation (r = -0.36, p < 0.05). These variables, together with the time in slow-wave sleep, accounted for a statistically significant but modest percentage of the variance in urinary norepinephrine (R2 = 0.19, p < 0.05). However, the variables were so tightly intercorrelated that no single variable independently predicted norepinephrine levels in multiple regression analysis.

journal_name

Chest

journal_title

Chest

authors

Dimsdale JE,Coy T,Ancoli-Israel S,Mills P,Clausen J,Ziegler MG

doi

10.1378/chest.111.3.639

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

639-42

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)46815-1

journal_volume

111

pub_type

杂志文章

相关文献

CHEST文献大全
  • Clinical significance of a multiple biomarker assay in patients with lung cancer. A study with logistic regression analysis.

    abstract::The relative usefulness of a combination of some tumor markers, such as CEA, AFP, ferritin and NSE for the diagnosis of lung cancer was assessed by multiple logistic analysis. Serum concentration of these markers was determined in 68 patients with lung cancer (50 with NSCLC and 18 with SCLC, in 68 patients with benign...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.3.639

    authors: Lombardi C,Tassi GF,Pizzocolo G,Donato F

    更新日期:1990-03-01 00:00:00

  • Analysis of indications for early discharge from the intensive care unit. Clinical efficacy assessment project: American College of Physicians.

    abstract:OBJECTIVE:To formulate recommendations for the development of early intensive care unit (ICU) discharge criteria for low-risk monitor patients. DESIGN:Literature review of published reports over the period 1966 to 1991 pertaining to ICU discharge criteria. PATIENTS:Studies identifying patients admitted to ICUs who co...

    journal_title:Chest

    pub_type: 指南,杂志文章

    doi:10.1378/chest.104.6.1812

    authors: Bone RC,McElwee NE,Eubanks DH,Gluck EH

    更新日期:1993-12-01 00:00:00

  • Candida colonization of the respiratory tract and subsequent pseudomonas ventilator-associated pneumonia.

    abstract:BACKGROUND:Recovery of Candida from the respiratory tract of a critically ill patient receiving mechanical ventilation (MV) usually indicates colonization rather than infection of the respiratory tract. However, interactions between Candida and bacteria, particularly Pseudomonas, have been reported. Thus, Candida colon...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.129.1.110

    authors: Azoulay E,Timsit JF,Tafflet M,de Lassence A,Darmon M,Zahar JR,Adrie C,Garrouste-Orgeas M,Cohen Y,Mourvillier B,Schlemmer B,Outcomerea Study Group.

    更新日期:2006-01-01 00:00:00

  • Efficacy of Acupuncture Is Noninferior to Nicotine Replacement Therapy for Tobacco Cessation: Results of a Prospective, Randomized, Active-Controlled Open-Label Trial.

    abstract:BACKGROUND:We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population. METHODS:This randomized controlled trial was conducted in seven h...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.chest.2017.11.015

    authors: Wang YY,Liu Z,Wu Y,Yang L,Guo LT,Zhang HB,Yang JS,Chinese Acupuncture for Tobacco Cessation Research Team.

    更新日期:2018-03-01 00:00:00

  • Intravenous and oral corticosteroids for the prevention of relapse after treatment of decompensated COPD. Effect on patients with a history of multiple relapses.

    abstract::To determine if a regimen of intravenous and oral corticosteroids reduces the relapse rate after treatment of decompensated COPD in the ED, 30 patients were studied. Forty-five visits in which intravenous and oral corticosteroids were given (T visits) were compared with an equal number of matched visits in which they ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.4.845

    authors: Murata GH,Gorby MS,Chick TW,Halperin AK

    更新日期:1990-10-01 00:00:00

  • Lack of efficacy for a cervicomandibular support collar in the management of obstructive sleep apnea.

    abstract:STUDY OBJECTIVES:The effect of therapy using a cervicomandibular support collar (CMSC) to manage obstructive sleep apnea (OSA) was compared with standard therapy, nasal continuous positive airway pressure (nCPAP). DESIGN:Subjects received treatment with CMSC or nCPAP each for 1 month in random order. The study was ana...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.125.1.118

    authors: Skinner MA,Kingshott RN,Jones DR,Taylor DR

    更新日期:2004-01-01 00:00:00

  • Ultrasound-guided thoracentesis: is it a safer method?

    abstract:STUDY OBJECTIVES:The objectives of this study are as follows: (1) to determine the incidence of complications from thoracentesis performed under ultrasound guidance by interventional radiologists in a tertiary referral teaching hospital; (2) to evaluate the incidence of vasovagal events without the use of atropine prio...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.123.2.418

    authors: Jones PW,Moyers JP,Rogers JT,Rodriguez RM,Lee YC,Light RW

    更新日期:2003-02-01 00:00:00

  • Outcome of treated advanced non-small cell lung cancer with and without central airway obstruction.

    abstract:OBJECTIVE:In patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy, we compared survival in patients with treated central airway obstruction to those who did not have central airway obstruction. METHODS:One hundred forty-four patients with advanced and inoperable NSCLC were included. Thes...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.6.1803

    authors: Chhajed PN,Baty F,Pless M,Somandin S,Tamm M,Brutsche MH

    更新日期:2006-12-01 00:00:00

  • Hemolysis in the aortic prosthetic valve.

    abstract::A review of the incidence and severity of hemolysis in the aortic prosthesis is presented. The noncloth-covered Starr-Edwards prosthetic series 1000, 1200, and 1260 had a 2 percent (1/54) incidence of anemia. The cloth-covered Starr-Edwards aortic prosthetic series 2300 was associated with anemia in 61 percent (28/46)...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.1.56

    authors: Santinga JT,Batsakis JT,Flora JD,Kirsh MM

    更新日期:1976-01-01 00:00:00

  • Physician-diagnosed COPD global initiative for chronic obstructive lung disease stage IV in Ostersund, Sweden: Patient characteristics and estimated prevalence.

    abstract:BACKGROUND:The prevalence of COPD is estimated to 4 to 14%. According to the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD is divided into four stages. Patients with stage IV disease (very severe) have FEV1 < 30% of predicted values and/or respiratory insufficiency. The few studies that exist ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.3.666

    authors: Stenfors N

    更新日期:2006-09-01 00:00:00

  • Preventing ventilator-associated pneumonia in adults: sowing seeds of change.

    abstract::Ventilator-associated pneumonia (VAP), a major cause of ICU infection, results in high morbidity, mortality, and health-care costs. Multiple risk factors for VAP involve complex host factors and ubiquitous pathogens that require several different types of prevention strategies. Prevention efforts should focus on reduc...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.130.1.251

    authors: Craven DE

    更新日期:2006-07-01 00:00:00

  • Chronic idiopathic cough: a discrete clinical entity?

    abstract:STUDY OBJECTIVES:Despite the success of specialist cough clinics, there is increasing recognition of a subgroup of chronic coughers in whom a diagnosis cannot be made even after thorough, systematic investigation. We call this condition chronic idiopathic cough (CIC). The aim of this study is to compare the clinical ch...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.5.1710

    authors: Haque RA,Usmani OS,Barnes PJ

    更新日期:2005-05-01 00:00:00

  • N-terminal pro-brain natriuretic peptide and renal insufficiency as predictors of mortality in pulmonary hypertension.

    abstract:BACKGROUND:N-terminal pro-brain natriuretic peptide (NT-proBNP) is a byproduct of the brain natriuretic peptide (BNP) that was shown to be of prognostic value in pulmonary hypertension (PH). The role of NT-proBNP in PH has to be determined, especially under the influence of renal impairment that might lead to an accumu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-1758

    authors: Leuchte HH,El Nounou M,Tuerpe JC,Hartmann B,Baumgartner RA,Vogeser M,Muehling O,Behr J

    更新日期:2007-02-01 00:00:00

  • Transbronchial lung biopsy via the fiberoptic bronchoscope. Experience with 107 consecutive cases and comparison with bronchial brushing.

    abstract::Transbronchial lung biopsy (TBB) was performed during fiberoptic bronchoscopy under fluoroscopic guidance in 107 patients. TBB was diagnostic in 17 of 21 (81 percent) cases with localized malignant lesions greater than 4 cm in diameter and bronchial brushing was positive in 12 (57 percent). TBB was diagnostic in 14 of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.68.4.524

    authors: Ellis JH Jr

    更新日期:1975-10-01 00:00:00

  • Effect of mild hypoxia on airway responsiveness to methacholine in subjects with airway hyperresponsiveness.

    abstract:STUDY OBJECTIVES:The inhalation of hypoxic gas has been reported to enhance the airway responsiveness to methacholine in some animal models. However, the data on humans have so far been conflicting. We attempted to examine the effect of hypoxic gas inhalation on the airway responsiveness to methacholine. DESIGN:We eva...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.116.6.1653

    authors: Saito H,Nishimura M,Shinano H,Sato F,Miyamoto K,Kawakami Y

    更新日期:1999-12-01 00:00:00

  • Immunosuppressive therapy in connective tissue diseases-associated pulmonary arterial hypertension.

    abstract:STUDY OBJECTIVE:Immune and inflammatory mechanisms could play a significant role in pulmonary arterial hypertension (PAH) genesis or progression, especially in patients with connective tissue diseases. Immunosuppressive therapy should be better evaluated in this setting. STUDY DESIGN:Monocentric retrospective study. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.1.182

    authors: Sanchez O,Sitbon O,Jaïs X,Simonneau G,Humbert M

    更新日期:2006-07-01 00:00:00

  • Early post-pneumonectomy bronchial stump fistula.

    abstract::Bronchial stump fistula occurred on the seventh postoperative day in a 45-year-old man who underwent right pneumonectomy for T2N2M0 adenocarcinoma of the lung. It was attributable to ventilator-related barotrauma during treatment of ARDS from multiple pulmonary emboli. A frequently lethal complication, its presentatio...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.3.654

    authors: Pomerantz AH,Derasari MD,Sethi SS,Khan S

    更新日期:1988-03-01 00:00:00

  • Transcutaneous oxygen monitoring during fiberoptic bronchoscopy.

    abstract::A transcutaneous oxygen sensor was used to detect the development of hypoxemia in patients undergoing fiberoptic bronchoscopy. Measurements of transcutaneous PO2 (tcPO2) correlated well with arterial PO2 (PaO2), and correctly detected all instances when PaO2 was less than 65 mm Hg. The sensor was noninvasive and cause...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.4.543

    authors: Ghows MB,Rosen MJ,Chuang MT,Sacks HS,Teirstein AS

    更新日期:1986-04-01 00:00:00

  • A comparison of two challenge tests for identifying exercise-induced bronchospasm in figure skaters.

    abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.3.649

    authors: Mannix ET,Manfredi F,Farber MO

    更新日期:1999-03-01 00:00:00

  • Interobserver Reliability of the Berlin ARDS Definition and Strategies to Improve the Reliability of ARDS Diagnosis.

    abstract:BACKGROUND:Failure to reliably diagnose ARDS may be a major driver of negative clinical trials and underrecognition and treatment in clinical practice. We sought to examine the interobserver reliability of the Berlin ARDS definition and examine strategies for improving the reliability of ARDS diagnosis. METHODS:Two hu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2017.11.037

    authors: Sjoding MW,Hofer TP,Co I,Courey A,Cooke CR,Iwashyna TJ

    更新日期:2018-02-01 00:00:00

  • Lymphocytic alveolitis in a crematorium worker.

    abstract::An asymptomatic cremator was found incidentally to have lymphocytic alveolitis by bronchoalveolar lavage, and the basis for this finding was investigated. No known causes of lymphocyte alveolitis including sarcoidosis, hypersensitivity pneumonitis, berylliosis, tuberculosis, or fungal diseases of the lung were found. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.2.617

    authors: Schauble TL,Rich EA

    更新日期:1994-02-01 00:00:00

  • Advanced emphysema in African-American and white patients: do differences exist?

    abstract:BACKGROUND:Emphysema is the only smoking-related disease in which white patients have higher prevalence and higher attributable mortality rates than African-American patients. Epidemiologic studies have not addressed, nor explained, the observed racial differences in emphysema. STUDY OBJECTIVES:To determine whether wh...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.1.108

    authors: Chatila WM,Hoffman EA,Gaughan J,Robinswood GB,Criner GJ,National Emphysema Treatment Trial Research Group.

    更新日期:2006-07-01 00:00:00

  • Effect of 30 mg of morphine alone or with promethazine or prochlorperazine on the exercise capacity of patients with COPD.

    abstract:OBJECTIVE:We have shown that the administration of 0.8 mg/kg of morphine (M) to patients with COPD resulted in a 20% increase in the maximum oxygen consumption (Vo2max), but was associated with significant drowsiness and euphoria. The objective of the present study was to ascertain whether lower doses of M alone or in ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.109.4.975

    authors: Light RW,Stansbury DW,Webster JS

    更新日期:1996-04-01 00:00:00

  • Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.

    abstract::To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.4.519

    authors: Katz JA,Kraemer RW,Gjerde GE

    更新日期:1985-10-01 00:00:00

  • ST-segment elevation during recovery from exercise. A new manifestation of Prinzmetal's variant angina.

    abstract::Four patients underwent exercise testing because of a history of pain in the chest; all four developed marked elevation of the S-T segment only during recovery after exercise. Three of the four patients showed ST-segment depression during exercise, but ST-segment elevation was absent until two or more minutes after ce...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.74.2.133

    authors: Weiner DA,Schick EC Jr,Hood WB Jr,Ryan TJ

    更新日期:1978-08-01 00:00:00

  • Lung mechanics and gas exchange during exercise in pulmonary sarcoidosis.

    abstract::To clarify how lung function at exercise is affected in sarcoidosis, and to analyze how exercise studies compare to testing measurements, 63 patients with pulmonary sarcoidosis were examined with lung mechanics and arterial blood gases during exercise. These findings were compared with simultaneously obtained, but pre...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.3.572

    authors: Brådvik I,Wollmer P,Blom-Bülow B,Albrechtsson U,Jonson B

    更新日期:1991-03-01 00:00:00

  • Bilateral diaphragm paralysis treated with cuirass ventilation.

    abstract::The therapeutic effects of cuirass ventilation were studied in two patients with bilateral diaphragm paralysis. Negative inspiratory and positive expiratory pressure applied to the cuirass shell was transmitted to the abdominal and thoracic cavities. Diaphragm excursion was enhanced. Nocturnal cuirass ventilation appe...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.4.683

    authors: Driver AG,Blackburn BB,Marcuard SP,Austin EH Jr

    更新日期:1987-10-01 00:00:00

  • Respiratory muscle training for respiratory deficits in neurodegenerative disorders: a systematic review.

    abstract:BACKGROUND:Studies of the impact of respiratory muscle training (RMT) on central neurodegenerative pathologies have been aimed at improving pulmonary function. However, there is no certainty about the effectiveness of RMT in patients affected by these groups of disorders. The purpose of this review was to assess the ev...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-1442

    authors: Reyes A,Ziman M,Nosaka K

    更新日期:2013-05-01 00:00:00

  • Crackles in patients with fibrosing alveolitis, bronchiectasis, COPD, and heart failure.

    abstract::We have studied the crackling lung sounds of ten patients with cryptogenic fibrosing alveolitis, ten with bronchiectasis, ten with chronic obstructive pulmonary disease, and ten with heart failure by analyzing frequency, waveform, and timing of crackles. The upper frequency limit of inspiratory sounds was higher in CF...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.5.1076

    authors: Piirilä P,Sovijärvi AR,Kaisla T,Rajala HM,Katila T

    更新日期:1991-05-01 00:00:00

  • Pregnancy in a woman with severe pulmonary fibrosis secondary to hard metal disease.

    abstract::The effect of interstitial pulmonary fibrosis on pregnancy is unclear. We present the findings in a 31-year-old woman with severe pulmonary fibrosis (vital capacity, 37 percent of predicted) secondary to hard metal disease who went through a successful term pregnancy. The patient was a grinder of tungsten-carbide dril...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.3.663

    authors: Ratto D,Balmes J,Boylen T,Sharma OP

    更新日期:1988-03-01 00:00:00