Abstract:
BACKGROUND:The prevalence of COPD is estimated to 4 to 14%. According to the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD is divided into four stages. Patients with stage IV disease (very severe) have FEV1 < 30% of predicted values and/or respiratory insufficiency. The few studies that exist have reported a stage IV disease prevalence of 0.1 to 0.2% but provide limited additional patient characteristics. The present study estimated the prevalence of physician-diagnosed stage IV COPD in the city of Ostersund, Sweden, and characterized the patients. METHODS:Due to the regional integrated care pathway, patients in whom severe COPD is diagnosed are under surveillance by the Respiratory Department at Ostersund Hospital. Among these patients and all others in whom COPD has been diagnosed at Ostersund Hospital from 2000 to 2004, all those with an FEV1 of < 40% predicted were examined. RESULTS:A total of 76 patients fulfilled the criteria for stage IV COPD. The mean age was 71 years, 59% were women, and 40% were receiving long-term oxygen therapy. Sixty-five percent of the patients lived independently at home, 9% were present smokers, and 75% used inhaled corticosteroids daily. Sixty-seven percent of the patients had received vaccination against influenza the previous year. During 2004, 48% of the patients had at least one COPD-related hospitalization, and 11% had made at least one visit to the hospital for emergency care. CONCLUSIONS:The present study indicated that 0.13% of the population in Ostersund in 2004 had physician-diagnosed stage IV COPD. This is probably an underestimation of the true prevalence. Patients with stage IV COPD appear to require periods of hospitalization more often than intermittent emergency department visits.
journal_name
Chestjournal_title
Chestauthors
Stenfors Ndoi
10.1378/chest.130.3.666subject
Has Abstractpub_date
2006-09-01 00:00:00pages
666-71issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(15)52776-1journal_volume
130pub_type
杂志文章相关文献
CHEST文献大全abstract::Negative pressure pulmonary edema (NPPE) is an important cause of noncardiogenic pulmonary edema but is rarely reported in the setting of bronchospasm. A 43-year-old woman with severe reactive airway disease suffered an episode of severe bronchospasm after endotracheal extubation following an otherwise uneventful gene...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0529
更新日期:2011-11-01 00:00:00
abstract::This is a report of an unusual case of left, predominantly upper lobe, pulmonary edema secondary to paravalvular mitral regurgitation (MR) complicating mitral valve replacement. Transesophageal echocardiography proved helpful in making the diagnosis of MR and suggesting the mechanism of the pulmonary edema. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.1.328
更新日期:1998-07-01 00:00:00
abstract:STUDY OBJECTIVES:Significant morbidity and mortality offset the benefits of lung volume reduction surgery (LVRS) for emphysema. By contributing to distal lung collapse, bronchoscopic placement of valved prostheses has the potential to noninvasively replicate the beneficial effects of LVRS. The purpose of this study was...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.3.1073
更新日期:2003-09-01 00:00:00
abstract::The effects of one hour exposures of healthy nonsmoking human volunteers to submicrometer H2SO4 droplets via nasal mask on tracheobronchial mucociliary particle clearance were studied using two different sized monodisperse gamma-tagged Fe2O3 test aerosols. The larger sized Fe2O3 aerosol, 7.5 micrometers AMAD, was depo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.80.6.873
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:To determine the incidence, diagnostic features, and perioperative predictors of acute cholecystitis after cardiovascular surgery. DESIGN:Inception cohort study. SETTING:A tertiary care 54-bed cardiothoracic ICU. PATIENTS:All patients admitted to an ICU after cardiovascular surgery during a 42-month period...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.114.1.76
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:Analysis of laryngotracheoscopic findings of the upper airway tract following percutaneous tracheostomy using the technique according to Griggs. DESIGN:Retrospective cohort study PATIENTS:Nineteen of 32 long-term surviving patients (mean follow-up duration, 17 months; range, 11 to 23 months) underwent a mod...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.1.206
更新日期:2002-07-01 00:00:00
abstract::The ventilatory effects of a bolus intravenous dose of doxapram (0.37 to 0.47 mg/kg) were studied in ten healthy normal subjects. An immediate significant (p less than 0.001) increase in minute ventilation (VE) was due, in equal part, to significant increases in tidal volume (VT) and frequency (f). The inspiratory (TI...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.5.600
更新日期:1984-05-01 00:00:00
abstract::We present a case of azathioprine-associated alveolitis diagnosed by gallium-67 scanning and transbronchial biopsy. The patient denied respiratory symptoms, exhibited spiking fevers, and had normal chest roentgenograms. Allopurinol inhibition of azathioprine metabolism may have been a contributing factor. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.4.696
更新日期:1983-04-01 00:00:00
abstract::Byssinosis first became compensatable in Great Britain in May 1941. The claimants were examined by a specially constituted board consisting of chest physicians and medical specialists from the Manchester area. Following the Industrial Injuries Act of 1946, which became operative in July 1948, the examinations were tak...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.4_supplement.124s
更新日期:1981-04-01 00:00:00
abstract::A 62-year-old woman presented with a 3-month history of abdominal distension and decreased exercise tolerance. A chest radiograph showed a probable left pleural effusion (Fig 1). A CT scan of the abdomen revealed a solid ovarian mass with omental caking and a large volume of ascites; there was also confirmation of a l...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2245
更新日期:2015-05-01 00:00:00
abstract::To minimize work of breathing, airway pressure should not fluctuate during spontaneous breathing with continuous positive airway pressure (CPAP). However, flow resistance in the inspiratory limb of the breathing circuit and an inadequate continuous gas flow rate result in airway pressure fluctuation and increased work...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.4.795
更新日期:1988-04-01 00:00:00
abstract:CASE PRESENTATION:A 34-year-old woman presented for evaluation of several months of a hoarse voice and dyspnea on exertion that progressed over the last 3 years. She had a clinical diagnosis of asthma that had been treated with bronchodilators and inhaled corticosteroids for a few years. She continued to use her inhale...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.01.021
更新日期:2019-06-01 00:00:00
abstract::Repeated aortic prosthetic valve endocarditis and aortic root abscesses were successfully treated by implantation of a valved conduit into the ascending aorta and by placement of saphenous vein grafts to the aorta distal to the conduit and to the right and left anterior descending coronary arteries. This procedure pro...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.6.832
更新日期:1984-06-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD are at risk of experiencing a deterioration in arterial oxygen saturation (SaO2) during sleep, which is generally most pronounced during rapid eye movement (REM) sleep. Increased cholinergic tone has been suggested as a contributing factor to this decrease in SaO2. Therefore, we inve...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.115.5.1338
更新日期:1999-05-01 00:00:00
abstract::We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.5.1454
更新日期:1992-05-01 00:00:00
abstract::Transforming growth factor (TGF)-beta is a multifunctional protein that initiates its diverse cellular responses by binding to and activating specific type I and type II serine/threonine kinase receptors. TGF-beta can act as a regulator of proliferation, migration, survival, differentiation, and extracellular matrix s...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.128.6_suppl.585S
更新日期:2005-12-01 00:00:00
abstract::A V/Q lung scan was obtained in a patient with LLL collapse who was receiving IPPV and PEEP. This revealed absent ventilation and hyperperfusion to the collapsed lobe. After a reduction in PEEP from 12 to 5 cm H2O, a repeat V/Q scan showed a more even distribution of pulmonary perfusion. Arterial hypoxemia improved. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.4.1034
更新日期:1991-04-01 00:00:00
abstract::Two cases of a Greenfield inferior vena cava (IVC) filter being dislodged during central venous catheter placement are described. This event appears to be related to J-tip guidewire use during venous catheterization. To our knowledge, this occurrence previously has not been reported. One of the two filters was dislodg...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.106.3.957
更新日期:1994-09-01 00:00:00
abstract::In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.101.3.810
更新日期:1992-03-01 00:00:00
abstract:STUDY OBJECTIVES:Despite the success of specialist cough clinics, there is increasing recognition of a subgroup of chronic coughers in whom a diagnosis cannot be made even after thorough, systematic investigation. We call this condition chronic idiopathic cough (CIC). The aim of this study is to compare the clinical ch...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.5.1710
更新日期:2005-05-01 00:00:00
abstract::The antimicrobial resistance problem in hospitals continues to worsen. In particular, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) and vancomycin-resistant enterococci (VRE) are significant causes of morbidity and mortality among critically ill patients. Treating infections caused by thes...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.119.2_suppl.426s
更新日期:2001-02-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the cause of pulmonary hypertension (PH) in systemic sclerosis (SSc) patients since PH can occur because of pulmonary arteriopathy, pulmonary parenchymal destruction, and left ventricular cardiac dysfunction. DESIGN AND SETTING:Consecutive case series in a university hospital. PATIENTS:N...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.4.1077
更新日期:2000-10-01 00:00:00
abstract::The current epidemic of acquired immune deficiency syndrome (AIDS) raises numerous public policy concerns for the medical community. The issues can be divided into two groups. Those concerns which require both immediate action and results are referred to as short-term issues. Those issues whose results will not be for...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.3.416
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Current functional assessments do not allow a reliable assessment of small airways, which are a major site of disease in COPD. Single-breath washout (SBW) tests are feasible and reproducible methods for evaluating small airway disease. Their relevance in COPD remains unknown. METHODS:We performed a cross-se...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.chest.2016.05.019
更新日期:2016-11-01 00:00:00
abstract::Between January 1990 and August 1991, there were 37 patients admitted to our Department of Internal Medicine with hematologic malignancies or solid tumors who showed colonization of the respiratory tract with Pseudomonas cepacia. Extensive surveillance cultures of the environmental surfaces and respiratory equipment o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.6.1706
更新日期:1993-06-01 00:00:00
abstract::The purpose of this study was to assess the ability of continuous nocturnal oximetry to detect sleep apnea syndrome (SAS) and to recognize nonapneic oxyhemoglobin desaturations. Oxygen saturation oscillations, related to successive apneas in SAS or to apneic episodes in COPD or restrictive patients, were quantified us...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.5.1151
更新日期:1991-05-01 00:00:00
abstract::Allergy prick skin testing was performed on 137 newly diagnosed patients with primary lung cancer and 137 age-(+/- 3 years) and sex-matched randomly selected control subjects. We also compared 38 patients with lung cancer and 38 of their closest in age, same-sex siblings. Demographic data, personal, medical, smoking a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.2.241
更新日期:1988-02-01 00:00:00
abstract::Two recent epidemiologic case-control studies suggested that fenoterol, a selective beta-adrenergic agonist, was associated with an increase in the risk of asthma death. The results of these studies were criticized because of methodologic problems in the choice and selection of control subjects; the different methods ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.6.1586
更新日期:1991-12-01 00:00:00
abstract:STUDY OBJECTIVE:Our group performed a randomized trial to assess whether the addition of endobronchial ultrasound (EBUS) guidance will lead to better results than standard transbronchial needle aspiration (TBNS). EBUS guidance seems to be beneficial in increasing the yield of TBNA but has not been proven to be superior...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.125.1.322
更新日期:2004-01-01 00:00:00
abstract:STUDY OBJECTIVES:To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults. DESIGN:Observational, retrospective study. SETTING:Fort Jackson, SC, May to July 1998. PARTICIPANTS:One hundred thirty-seve...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.6.1676
更新日期:2001-06-01 00:00:00