Clinical complexity and epidemiologic uncertainty in case-control research. Fenoterol and asthma management.

Abstract:

:Two recent epidemiologic case-control studies suggested that fenoterol, a selective beta-adrenergic agonist, was associated with an increase in the risk of asthma death. The results of these studies were criticized because of methodologic problems in the choice and selection of control subjects; the different methods used to gather exposure data in cases and control subjects; and because of inadequate classification and adjustment for asthma severity. In response to this controversy, a new study is underway, the Saskatchewan Asthma Epidemiology Project. The SAEP includes two complementary studies, an historic cohort and a case-control analysis, that employ the computerized databases of the Saskatchewan Health Department. A unique aspect of the SAEP is the attempt to incorporate knowledge of asthma physiology and management into the design of the studies. Specifically, the study design recognized the role of antiinflammatory drugs in asthma treatment; the distinction between asthma death and near-fatal asthma; the severity of asthma; patterns of drug use; and the distinction between inadequate clinical care and disease severity. The strategies we employed in the SAEP may prove helpful to investigators whenever clinical and biologic processes create sources of potential bias requiring special procedures for the design and analysis of epidemiologic studies.

journal_name

Chest

journal_title

Chest

authors

Horwitz RI,Spitzer W,Buist S,Cockcroft D,Ernst P,Habbick B,Hemmelgarn B,McNutt M,Rebuck AS,Suissa S

doi

10.1378/chest.100.6.1586

subject

Has Abstract

pub_date

1991-12-01 00:00:00

pages

1586-91

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)52798-6

journal_volume

100

pub_type

杂志文章

相关文献

CHEST文献大全
  • Diminished natural killer-cell activity of interstitial pulmonary cell populations from patients with carcinoma of the lung.

    abstract::Natural killer-cell activity of fresh interstitial pulmonary cell populations from patients with squamous cell and adenocarcinoma of the lung and carcinoma metastatic to the lung was assessed and compared to that of apparently normal lung. No increase in the percentage of lymphoid cell populations was noted in the int...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.1.26

    authors: deShazo RD,Moulder PV,Bozelka B,Chapman Y

    更新日期:1987-01-01 00:00:00

  • Persistence of lung function abnormalities despite sustained success of percutaneous mitral valvotomy: the need for an early indication.

    abstract:AIMS:We assessed early and long-term pulmonary function changes after percutaneous balloon mitral valvotomy (PBMV). METHODS AND RESULTS:Mitral area, lung function, and exercise capacity were evaluated before, immediately after, and 3 months, 6 months, and 12 months after successful PBMV in 24 patients. PBMV resulted i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.1.40

    authors: Gómez-Hospital JA,Cequier A,Romero PV,Cañete C,Ugartemendia C,Iràculis E,Esplugas E

    更新日期:2005-01-01 00:00:00

  • Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage.

    abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.6.1794

    authors: Grebski E,Hess T,Hold G,Speich R,Russi E

    更新日期:1992-12-01 00:00:00

  • Evaluating Knowledge, Attitudes, and Beliefs About Lung Cancer Screening Using Crowdsourcing.

    abstract:BACKGROUND:Lung cancer screening, despite its proven mortality benefit, remains vastly underutilized. Previous studies examined knowledge, attitudes, and beliefs to better understand the reasons underlying the low screening rates. These investigations may have limited generalizability because of traditional participant...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.12.048

    authors: Monu J,Triplette M,Wood DE,Wolff EM,Lavallee DC,Flum DR,Farjah F

    更新日期:2020-07-01 00:00:00

  • Decortication after 35 years.

    abstract::A 66-year-old white woman had a paraffin plombage performed in 1940 for tuberculosis. In 1975, she had decortication for terminal respiratory insufficiency, with return to an active life. Thirty-five years of pulmonary compression does not produce irreversible changes in the pulmonary parenchyma. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.5.668

    authors: Knudsen DF

    更新日期:1977-05-01 00:00:00

  • Investigating the natural history of lung function: facts, pitfalls, and opportunities.

    abstract::COPD is currently defined as a progressive, preventable, and treatable disease that is characterized by an accelerated decline of lung function. However, contrary to other common chronic conditions like cardiovascular disease or cancer, there are no lifelong population-based studies describing the natural history of l...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.08-1750

    authors: Kohansal R,Soriano JB,Agusti A

    更新日期:2009-05-01 00:00:00

  • Long-term Outcomes After Stepping Down Asthma Controller Medications: A Claims-Based, Time-to-Event Analysis.

    abstract:BACKGROUND:Long-term outcomes after stepping down asthma medications are not well described. METHODS:This study was a retrospective time-to-event analysis of individuals diagnosed with asthma who stepped down their asthma controller medications using a US claims database spanning 2000 to 2012. Four-month intervals wer...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.15-0301

    authors: Rank MA,Johnson R,Branda M,Herrin J,van Houten H,Gionfriddo MR,Shah ND

    更新日期:2015-09-01 00:00:00

  • The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period.

    abstract:BACKGROUND:Studies evaluating the dose of epinephrine required to optimize return of spontaneous circulation and survival after CPR have shown that doses greater than recommended by advanced cardiac life support (ACLS) improve coronary perfusion pressure and short-term resuscitation rates. Since survival has not improv...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.106.5.1499

    authors: Rivers EP,Wortsman J,Rady MY,Blake HC,McGeorge FT,Buderer NM

    更新日期:1994-11-01 00:00:00

  • A comparison of the Jones and Stead-Wells spirometers.

    abstract::A comparison was made between the noncounterweighted Jones and Stead-Wells spirometers, and "conversion factors" were determined for the forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC). A cross-sectional study produced a high correlation between the instruments for these two measureme...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.5.596

    authors: Glindmeyer HW,Anderson ST,Diem JE,Weill H

    更新日期:1978-05-01 00:00:00

  • Reversal of central sleep apnea using nasal CPAP.

    abstract::Based on the theory that obstructive (OSA) and central (CSA) sleep apneas share common pathophysiologic mechanisms, we attempted to treat eight patients with predominantly CSA by continuous positive airway pressure (CPAP). All patients exhibited repetitive episodes of CSA and mixed sleep apneas (MSA) in the supine pos...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.2.165

    authors: Issa FG,Sullivan CE

    更新日期:1986-08-01 00:00:00

  • Simplified prediction rule for prognosis of patients with severe community-acquired pneumonia in ICUs.

    abstract:STUDY OBJECTIVES:To develop a simplified prognostic prediction rule for patients admitted to ICUs for severe community-acquired pneumonia (CAP). SETTING:Six ICUs in the north of France. PATIENTS:Five hundred five patients admitted to ICUs over a 9-year period (from 1987 to 1995) for severe CAP. INTERVENTIONS:Retrosp...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.116.1.157

    authors: Leroy O,Devos P,Guery B,Georges H,Vandenbussche C,Coffinier C,Thévenin D,Beaucaire G

    更新日期:1999-07-01 00:00:00

  • Differential coronary calcification on electron-beam CT between syndrome X and coronary artery disease in patients with chronic stable angina pectoris.

    abstract:STUDY OBJECTIVES:The differential diagnosis of syndrome X and coronary artery disease (CAD) in patients with evidence of myocardial ischemia may be difficult. The possible difference in coronary calcium detected by electron-beam CT (EBCT) between syndrome X and CAD is rarely evaluated, especially in aged patients with ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.120.5.1525

    authors: Chen LC,Chen JW,Wu MH,Liu JC,Lan GY,Ding PY,Chang MS

    更新日期:2001-11-01 00:00:00

  • Subepicardial infarction, myocardial impression, and ventricular penetration by sutureless electrode and leads.

    abstract::Postmortem examination two weeks following implantation of a demand pacemaker with sutureless electrodes demonstrated that (1) the loops of intrapericardial electrode leads indented the myocardium and produced a circumscribed area of subepicardial necrosis, and (2) one of the electrode coils protruded into the right v...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.1.80

    authors: Steinke WE,Thomas FT,ul Hassan Z,Mendoza RA,Gear AS

    更新日期:1976-07-01 00:00:00

  • Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.

    abstract::To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.4.519

    authors: Katz JA,Kraemer RW,Gjerde GE

    更新日期:1985-10-01 00:00:00

  • Pulmonary Mycobacterium kansasii infection in Israel, 1999-2004: clinical features, drug susceptibility, and outcome.

    abstract:BACKGROUND:Mycobacterium kansasii infection is one of the most common causes of nontuberculous mycobacterial lung disease in world. However, little is known about its background characteristics or drug sensitivity in nonendemic areas. DESIGN:We assessed the clinical features, radiologic findings, and drug sensitivity ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.129.3.771

    authors: Shitrit D,Baum GL,Priess R,Lavy A,Shitrit AB,Raz M,Shlomi D,Daniele B,Kramer MR

    更新日期:2006-03-01 00:00:00

  • Coccidioidal pericarditis.

    abstract::A 26-year-old man developed coccidioidomycosis which resulted in myocarditis associated with congestive heart failure. A pericardial effusion developed and progressed to constrictive pericarditis. A pericardiectomy was performed and revealed that the pericarditis was due to Coccidioides immitis. The patient was subseq...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.5.670

    authors: Schwartz EL,Waldmann EB,Payne RM,Goldfarb D,Kinard SA

    更新日期:1976-11-01 00:00:00

  • Rapidly reversible alterations of pulmonary epithelial permeability induced by smoking.

    abstract::A radioaerosol procedure using 99mcTc-DTPA (diethylene triamine penta acetate) was used to evaluate the permeability of the pulmonary epithelium in smokers and nonsmokers. The average clearance of this indicator from the lungs of smokers without significant airway obstruction exceeded that found in normal subjects by ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.1.6

    authors: Mason GR,Uszler JM,Effros RM,Reid E

    更新日期:1983-01-01 00:00:00

  • Skin sensitivity to histolyn, spherulin, and PPD in the People's Republic of China.

    abstract::One hundred one subjects living in northwest Hunan Province, People's Republic of China (PRC) were tested with histolyn, (Berkeley Biological Laboratories), spherulin (Berkeley Biological Laboratories), and tubersol (PPD 5 tuberculin units, Connaught Laboratories). Age of the tested subjects ranged from 16 to 58 years...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.6.1356

    authors: Baum GL,Wu JN,Hua SS,Baum C,Ajello L

    更新日期:1990-06-01 00:00:00

  • Variability in lung collagen amounts after prolonged support of acute respiratory failure.

    abstract::In order to identify correlates of fibrosis in acute respiratory failure, autopsies were performed on 16 patients who died after an episode of more than two weeks' duration, and the left lower lung lobe was obtained for biochemical measurements. The average amount of lobar collagen in one group of patients was nearly ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.5.641

    authors: Collins JF,Smith JD,Coalson JJ,Johanson WG Jr

    更新日期:1984-05-01 00:00:00

  • Abdominal placement of tube thoracostomy due to lack of recognition of paralysis of hemidiaphragm.

    abstract::Tube thoracostomy is an invasive procedure that carries a risk of complications. We report a patient with liver cirrhosis, ascites and large left-sided pleural effusion, in whom a trocar type chest tube was inserted at the seventh left intercostal space in the midaxillary line. Chest roentgenogram revealed that the dr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.1.292

    authors: Foresti V,Villa A,Casati O,Parisio E,De Filippi G

    更新日期:1992-07-01 00:00:00

  • Treatment of diffuse tracheomalacia secondary to relapsing polychondritis with continuous positive airway pressure.

    abstract::Relapsing polychondritis (RP) is a rare disease characterized by recurrent inflammation and destruction of the cartilaginous structures. Tracheobronchial chondritis is a dreaded complication of RP. We wish to report a case of RP of the trachea and bronchi which was treated with nasal continuous positive airway pressur...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.112.6.1701

    authors: Adliff M,Ngato D,Keshavjee S,Brenaman S,Granton JT

    更新日期:1997-12-01 00:00:00

  • Alternatively activated macrophages and airway disease.

    abstract::Macrophages are the most abundant immune cell population in normal lung tissue and serve critical roles in innate and adaptive immune responses as well as the development of inflammatory airway disease. Studies in a mouse model of chronic obstructive lung disease and translational studies of humans with asthma and COP...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.10-2132

    authors: Byers DE,Holtzman MJ

    更新日期:2011-09-01 00:00:00

  • Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking.

    abstract:STUDY OBJECTIVE:To determine the indications for preoperative localization of a small indeterminate pulmonary nodule. DESIGN:In this retrospective study, univariate and multivariate analyses were performed by the logistic regression procedure. SETTING:A single National Cancer Center Hospital in Japan. PATIENTS:A ser...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.2.563

    authors: Suzuki K,Nagai K,Yoshida J,Ohmatsu H,Takahashi K,Nishimura M,Nishiwaki Y

    更新日期:1999-02-01 00:00:00

  • High frequency of atopic asthma in a pulmonary clinic population.

    abstract::Seventy-two consecutive adult asthmatic patients seen in the Pulmonary Clinic at Rhode Island Hospital were tested for atopy by prick test with 14 standard aeroallergens and by in vitro total and specific IgE determinations (FAST). A total of 58.3 percent of patients were found to be atopic by these tests. There was a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.6.1336

    authors: Kalliel JN,Goldstein BM,Braman SS,Settipane GA

    更新日期:1989-12-01 00:00:00

  • Modification of the effect of fiberoptic bronchoscopy on pulmonary mechanics.

    abstract::Thirty-three patients who were to undergo diagnostic fiberoptic bronchoscopy were studied. Pulmonary function tests were performed before the procedure, after topical lidocaine anesthesia, and immediately and four hours after bronchoscopy. Nine patients received aerosolized isoproterenol (Isuprel) before the topical a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.5.516

    authors: Belen J,Neuhaus A,Markowitz D,Rotman HH

    更新日期:1981-05-01 00:00:00

  • Pneumococcal infection and immunologic response to pneumococcal vaccine in chronic obstructive pulmonary disease. A pilot study.

    abstract::We assessed the importance of Streptococcus pneumoniae and immunologic response to 14-valent pneumococcal vaccine in a randomized (saline placebo or vaccine) double-blind pilot study involving 103 patients with chronic obstructive pulmonary disease (COPD). Antibody titers, the flora of the sputum, respiratory infectio...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.92.2.204

    authors: Davis AL,Aranda CP,Schiffman G,Christianson LC

    更新日期:1987-08-01 00:00:00

  • The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project.

    abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-2096

    authors: Lip GYH,Clementy N,Pierre B,Boyer M,Fauchier L

    更新日期:2015-04-01 00:00:00

  • Brief questionnaires for patient-reported outcomes in asthma: validation and usefulness in a primary care setting.

    abstract:UNLABELLED:STUDY OBJECTIVES AND DESIGN: Health-related quality of life (QoL) instruments are generally used for studies of asthma in specialized settings. For primary care use, there is a need for brief and simple questionnaires for structured patient-reported outcomes. We validated the Mini-Asthma Quality of Life Ques...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.129.4.925

    authors: Ehrs PO,Nokela M,Ställberg B,Hjemdahl P,Wikström Jonsson E

    更新日期:2006-04-01 00:00:00

  • Tuberculosis and pregnancy. Five- to ten-year review of 215 patients in their fertile age.

    abstract::This study evaluated the influence of pregnancy as a relapse factor in pulmonary tuberculosis in 215 patients who recieved adequate chemotherapy. A comparison was made between the evolution of patients who had pregnancies and those who did not. On ending the period of observation (details are lacking with respect to o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.68.6.800

    authors: de March A P

    更新日期:1975-12-01 00:00:00

  • Sublingual capnography: a clinical validation study.

    abstract:OBJECTIVE:To compare sublingual PCO(2) (PslCO(2)) measurements with gastric intramucosal PCO(2) (PimCO(2)) as well as with the traditional indexes of tissue oxygenation in hemodynamically unstable ICU patients. DESIGN:A prospective, validation study. SETTING:The medical and coronary ICUs of a community teaching hospi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.3.923

    authors: Marik PE

    更新日期:2001-09-01 00:00:00