Investigating the natural history of lung function: facts, pitfalls, and opportunities.

Abstract:

:COPD is currently defined as a progressive, preventable, and treatable disease that is characterized by an accelerated decline of lung function. However, contrary to other common chronic conditions like cardiovascular disease or cancer, there are no lifelong population-based studies describing the natural history of lung function and COPD. In this review, we describe the methodology used in population-based studies, both American and European, that have formed the basis of our current understanding of the "natural history" of COPD, including studies with serial pulmonary function testing, which hold potential for further investigations. We highlight the methodological limitations of longitudinal studies and suggest possible solutions. Finally, some characteristics of an "ideal" study on the natural history of lung function decline are recommended, both in health and disease.

journal_name

Chest

journal_title

Chest

authors

Kohansal R,Soriano JB,Agusti A

doi

10.1378/chest.08-1750

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1330-1341

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(09)60315-9

journal_volume

135

pub_type

杂志文章,评审

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