Histoplasma capsulatum endocarditis cured by amphotericin B combined with surgery.

Abstract:

:A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirmed by culture of the organism from blood. An echocardiogram compared to a previous normal echocardiogram indicated changes consistent with a vegetation. Histologic examination of the resected valve demonstrated organisms. Amphotericin B administration (3.4 g) plus an aortic valve replacement resulted in cure.

journal_name

Chest

journal_title

Chest

authors

Bradsher RW,Wickre CG,Savage AM,Harston WE,Alford RH

doi

10.1378/chest.78.5.791

subject

Has Abstract

pub_date

1980-11-01 00:00:00

pages

791-5

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)31124-2

journal_volume

78

pub_type

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