Immune Checkpoint Immunotherapy for Non-Small Cell Lung Cancer: Benefits and Pulmonary Toxicities.

Abstract:

:Immune checkpoint inhibitors (ICIs) are newer, immunotherapy-based drugs that have been shown to improve survival in advanced non-small cell lung cancer (NSCLC). Unlike traditional chemotherapeutic agents, ICIs work by boosting the body's natural tumor killing response. However, this unique mechanism of action has also led to the recognition of class-specific side effects. Labeled immune-related adverse events, these toxicities can affect multiple organ systems including the lungs. Immune-mediated lung injury because of ICI use, termed checkpoint inhibitor pneumonitis (CIP), occurs in about 3% to 5% of patients receiving ICIs; however, the real-world incidence of this entity may be higher, especially now that ICIs are being used in nonclinical trial settings. In this review, we briefly introduce the biology of ICIs and the indications for ICI use in NSCLC and then discuss the epidemiology and clinical and radiologic manifestations of CIP. Next, we discuss management strategies for CIP, including the current consensus on management of steroid-refractory CIP. Given the nascent nature of this field, we highlight areas of uncertainty and emerging research questions in the burgeoning field of checkpoint inhibitor pulmonary toxicity.

journal_name

Chest

journal_title

Chest

authors

Suresh K,Naidoo J,Lin CT,Danoff S

doi

10.1016/j.chest.2018.08.1048

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1416-1423

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(18)32336-5

journal_volume

154

pub_type

杂志文章,评审

相关文献

CHEST文献大全
  • Atrial function during cardiac arrest caused by ventricular fibrillation.

    abstract:OBJECTIVES:To report observations on preserved regular atrial electrical and mechanical systole during ventricular fibrillation (VF) and to quantitate blood flow generated by atrial contractions in this setting. METHODS:In 10 rats, right atrial pressure pulses were continuously recorded before and for an interval of 8...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.4.1118

    authors: Pernat A,Weil MH,Sun S,Tang W,Yamaguchi H,Bisera J

    更新日期:2000-04-01 00:00:00

  • Iron lung vs mask ventilation in the treatment of acute on chronic respiratory failure in COPD patients: a multicenter study.

    abstract:STUDY OBJECTIVES:Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN:A retrospective case-control study. SETTING:Four Italian respir...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.121.1.189

    authors: Corrado A,Confalonieri M,Marchese S,Mollica C,Villella G,Gorini M,Della Porta R

    更新日期:2002-01-01 00:00:00

  • Sleep medicine training across the spectrum.

    abstract::There is now a new pathway and examination for sleep medicine, sponsored by the American Board of Internal Medicine, and a number of accredited sleep medicine fellowship programs through the Accreditation Council for Graduate Medical Education. This review takes an historical approach to discuss the process of educati...

    journal_title:Chest

    pub_type: 历史文章,杂志文章,评审

    doi:10.1378/chest.10-0783

    authors: Strohl KP

    更新日期:2011-05-01 00:00:00

  • Bilateral functioning Vineberg grafts. A 25-year follow-up.

    abstract::This report describes a 25-year follow-up of angiographically proven bilateral functioning Vineberg grafts. This represents the longest angiographic follow-up found in the literature. The relevance of these grafts in present-day revascularization procedures is discussed. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.3.824

    authors: Hughes MM

    更新日期:1997-03-01 00:00:00

  • Effects of aortic balloon pumping during cardiopulmonary bypass on myocardial perfusion, metabolism, and contractility.

    abstract::This study was undertaken to determine if the production of pulsatile flow by the intra-aortic balloon pump during cardiopulmonary bypass has any beneficial effect on coronary flow, regional myocardial flow, myocardial metabolism, and left ventricular function. Thirty-six conditioned dogs were subjected to one hour of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.75.1.37

    authors: Grover FL,Fewel JG,Vinas J,Ghidoni JJ,Arom KV,Norton JB Jr,Trinkle JK

    更新日期:1979-01-01 00:00:00

  • The prone position in ARDS patients. A clinical study.

    abstract::The gas exchange and hemodynamics were evaluated before, during, and after a two-hour period of prone position in 13 moderate-severe ARDS patients. Lung computerized tomography was obtained in both the supine and prone positions in two of these patients. Average arterial oxygenation improved after prone positioning (p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.1.103

    authors: Langer M,Mascheroni D,Marcolin R,Gattinoni L

    更新日期:1988-07-01 00:00:00

  • Pleural calcification associated with exposure to chrysotile asbestos in southeast Turkey.

    abstract::In this study, pleural calcifications prevailing in the inhabitants of some villages and towns around Diyarbakir, a city in southeast Turkey, have been found to be caused by the inhalation of chrysotile asbestos, the mineral commonly used indiscriminately to paint the walls and floors of houses. There were no industri...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.70.1.43

    authors: Yazicioglu S

    更新日期:1976-07-01 00:00:00

  • Questionnaires and pocket spirometers provide an alternative approach for COPD screening in the general population.

    abstract:BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.11-1474

    authors: Nelson SB,LaVange LM,Nie Y,Walsh JW,Enright PL,Martinez FJ,Mannino DM,Thomashow BM

    更新日期:2012-08-01 00:00:00

  • Color Doppler ultrasonography for the assessment of renal blood flow in heart failure.

    abstract::To validate color Doppler ultrasonography of renal arteries for the assessment of renal blood flow (RBF), we compared left and right RBF estimates and their sum (total RBF) by echo-Doppler with data obtained by iodine 123-123I-p-aminohippuric acid (PAH) scintigraphy in 19 patients with heart failure and 7 normal contr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.4.912

    authors: Vigna C,Russo A,Barbano F,Fusilli S,Loperfido F

    更新日期:1995-10-01 00:00:00

  • The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project.

    abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-2096

    authors: Lip GYH,Clementy N,Pierre B,Boyer M,Fauchier L

    更新日期:2015-04-01 00:00:00

  • Hemolysis in the aortic prosthetic valve.

    abstract::A review of the incidence and severity of hemolysis in the aortic prosthesis is presented. The noncloth-covered Starr-Edwards prosthetic series 1000, 1200, and 1260 had a 2 percent (1/54) incidence of anemia. The cloth-covered Starr-Edwards aortic prosthetic series 2300 was associated with anemia in 61 percent (28/46)...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.1.56

    authors: Santinga JT,Batsakis JT,Flora JD,Kirsh MM

    更新日期:1976-01-01 00:00:00

  • The effect of intravenous amiodarone on heart rate in patients with acute myocardial infarction or ischemia and sinus tachycardia.

    abstract::The effect of intravenous (IV) amiodarone (300 mg) on heart rate was investigated in 22 patients with acute myocardial infarction (18) or ischemia (4) and sinus tachycardia. There were 11 men and 11 women (age range, 48 to 83 years; mean, 63.5). Amiodarone IV slowed the mean heart rate from 109 +/- 14 beats/min to 94 ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.3.584

    authors: Kusniec J,Strasberg B,Sclarovsky S,Klainman E,Agmon J

    更新日期:1988-09-01 00:00:00

  • Left pleural hemorrhagic effusion. A presenting sign of thoracic aortic dissecting aneurysm.

    abstract::Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.636

    authors: Gandelman G,Barzilay N,Krupsky M,Resnitzky P

    更新日期:1994-08-01 00:00:00

  • An 80-Year-Old Man With Dyspnea and Bilateral Pleural Effusions After Partial Nephrectomy for Renal Cell Carcinoma.

    abstract::An 80-year-old man presented because of superficial head trauma sustained after falling from bed. On review of systems, he reported worsening dyspnea on exertion, nonproductive cough, and weight loss over the preceding 2 to 3 months. There was no report of chest pain or leg swelling. He had a past medical history of h...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2015.12.023

    authors: Gupta A,Farokhi M,Shah S,McGarry T,Warshawsky M,Epelbaum O

    更新日期:2016-05-01 00:00:00

  • Usefulness of fine-needle aspiration biopsy of spleen in diagnosis of sarcoidosis.

    abstract::Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.2.193

    authors: Selroos O,Koivunen E

    更新日期:1983-02-01 00:00:00

  • Stenosis of main bronchi mimicking fixed upper airway obstruction in sarcoidosis.

    abstract::An unusual site and cause of disabling inspiratory and expiratory airflow limitation mimicking fixed upper airway obstruction is reported in two patients with sarcoidosis who had stenosis of almost the entire lengths of both main bronchi. The observed flows were consistent with a cross sectional airway diameter of 3 m...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.2.244

    authors: Miller A,Brown LK,Teirstein AS

    更新日期:1985-08-01 00:00:00

  • A case of orthodeoxia caused by an atrial septal aneurysm.

    abstract::Platypnea-orthodeoxia is an uncommon syndrome that may occur due to the postpneumonectomy state, cirrhosis of the liver, recurrent pulmonary embolism, and intracardiac shunting. We describe a patient who was found to have a positional change in desaturation after being admitted for dehydration. Workup revealed an atri...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.3.871

    authors: Acharya SS,Kartan R

    更新日期:2000-09-01 00:00:00

  • Effect of mechanical ventilation on hepatic drug pharmacokinetics.

    abstract::Mechanical ventilation was able to induce a decrease in cardiac output and regional blood flow, especially hepatic flow. Thus, hepatic elimination of drugs with a high hepatic-extraction ratio, which was linked to alteration in hepatic blood flow, could be reduced during mechanical ventilation. The aim of this work wa...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.6.837

    authors: Richard C,Berdeaux A,Delion F,Riou B,Rimailho A,Giudicelli JF,Auzépy P

    更新日期:1986-12-01 00:00:00

  • Continuous monitoring of mixed venous oxygen saturation in patients with acute myocardial infarction.

    abstract::Continuous measurement of mixed venous oxygen saturation (SvO2) has been suggested as an adjunct in monitoring critically ill patients. We evaluated SvO2 monitoring in 24 patients suffering from complicated myocardial infarctions. Cardiac output and arterial lactate levels were measured when there were persistent 5 pe...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.3.607

    authors: Kyff JV,Vaughn S,Yang SC,Raheja R,Puri VK

    更新日期:1989-03-01 00:00:00

  • Simulation Training in the ICU.

    abstract::Because of an emphasis on patient safety and recognition of the effectiveness of simulation as an educational modality across multiple medical specialties, use of health-care simulation (HCS) for medical education has become more prevalent. In this article, the effectiveness of simulation for areas important to the pr...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2019.07.011

    authors: Seam N,Lee AJ,Vennero M,Emlet L

    更新日期:2019-12-01 00:00:00

  • Pulmonary granulomatosis caused by aspirated green tea.

    abstract::We describe the first reported case (to our knowledge) of pulmonary granulomatosis caused by aspirated green tea. In this case, we found granulomatous alveolitis with lymph follicles, T lymphocytosis with predominantly CD8+ cells in the bronchoalveolar lavage fluids, positive serum precipitin and proliferative respons...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.1.308

    authors: Sakamoto O,Saita N,Yamasaki H,Tamanoi M,Ando M

    更新日期:1994-07-01 00:00:00

  • The maximal expiratory flow-volume curve in normal subjects in India.

    abstract::Data on pulmonary function, with particular reference to flow-volumes, were obtained in 760 normal healthy Indians in Bombay, who had never smoked and who had no symptom or history of cardiorespiratory disease. Prediction equations were derived for spirometric parameters and for maximal expiratory flows. The maximal e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.6.852

    authors: Udwadia FE,Sunavala JD,Shetye VM,Jain PK

    更新日期:1986-06-01 00:00:00

  • Gastric rupture complicating post-extubation laryngeal edema and the use of a manual resuscitation bag.

    abstract::This report describes a patient who developed gastric rupture as a result of post-extubation laryngeal edema and the use of a manual resuscitation bag. The association between oxygen administraton and gastric rupture is reviewed. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.76.3.324

    authors: Eichenhorn MS

    更新日期:1979-09-01 00:00:00

  • Idiopathic pulmonary hypertension associated with nodular pulmonary infiltrates and portal venous thrombosis.

    abstract::A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual asso...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.78.1.111

    authors: Bower JS,Dantzker DR,Naylor B

    更新日期:1980-07-01 00:00:00

  • Acute diverticulitis following cardiac surgery.

    abstract::Gastrointestinal complications requiring surgical correction following cardiopulmonary bypass most frequently involve the upper gastrointestinal tract. Surgical diseases of the colon are quite unusual in this setting. We recently performed cardiac surgery on three patients who developed acute diverticulitis requiring ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.5.756

    authors: Burton NA,Albus RA,Graeber GM,Lough FC

    更新日期:1986-05-01 00:00:00

  • A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy.

    abstract::Propofol, a new intravenous sedative agent, was investigated in 41 asthmatic patients undergoing day-case (outpatient) fiberoptic bronchoscopy. The study design was a randomized comparison between propofol and midazolam, which is a well-established intravenous sedative agent. The age, weight, and American Society of A...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.104.4.1029

    authors: Clarkson K,Power CK,O'Connell F,Pathmakanthan S,Burke CM

    更新日期:1993-10-01 00:00:00

  • A comparative study of oral endotracheal tube securing methods.

    abstract::A prospective study was done to compare four different methods of securing oral endotracheal tubes: adhesive tape (A), Twill tape (T), Twill tape with FlexBlue bite block (TFXB), and Velcro tie with FlexBlue (VFXB), used on sequential days. Thirty-six patients were enrolled for 136 patient-days and 18 had complete 4-d...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.5.1537

    authors: Levy H,Griego L

    更新日期:1993-11-01 00:00:00

  • Mine is bigger than yours: measures of effect size in research.

    abstract::Results of studies that use laboratory tests are often easy to interpret, because we are familiar with the units and how to interpret them. However, this is not the case when the results are presented as ORs, relative risks, correlation, or scores on an unfamiliar scale. This article explains these various indices of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.11-2473

    authors: Streiner DL,Norman GR

    更新日期:2012-03-01 00:00:00

  • Pain and physical function are similar following axillary, muscle-sparing vs posterolateral thoracotomy.

    abstract:STUDY OBJECTIVES:We set out to determine whether there is a difference in postoperative pain and recovery after the patient undergoes the axillary muscle-sparing incision (ie, muscle-sparing thoracotomy [MT]) vs the modified posterolateral incision (ie, posterolateral thoracotomy [PT]). DESIGN:Analysis of a database o...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.128.4.2664

    authors: Ochroch EA,Gottschalk A,Augoustides JG,Aukburg SJ,Kaiser LR,Shrager JB

    更新日期:2005-10-01 00:00:00

  • Reduction of pulmonary surfactant in patients with human immunodeficiency virus infection and Pneumocystis carinii pneumonia.

    abstract::We assessed qualitative and quantitative differences in surfactant lipid composition of bronchoalveolar lavage (BAL) fluid in patients with acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii (PC) pneumonia. Five normal volunteers and 27 patients with human immunodeficiency virus (HIV) infection underw...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.6.1730

    authors: Hoffman AG,Lawrence MG,Ognibene FP,Suffredini AF,Lipschik GY,Kovacs JA,Masur H,Shelhamer JH

    更新日期:1992-12-01 00:00:00