Abstract:
:Immune checkpoint inhibitors (ICIs) are newer, immunotherapy-based drugs that have been shown to improve survival in advanced non-small cell lung cancer (NSCLC). Unlike traditional chemotherapeutic agents, ICIs work by boosting the body's natural tumor killing response. However, this unique mechanism of action has also led to the recognition of class-specific side effects. Labeled immune-related adverse events, these toxicities can affect multiple organ systems including the lungs. Immune-mediated lung injury because of ICI use, termed checkpoint inhibitor pneumonitis (CIP), occurs in about 3% to 5% of patients receiving ICIs; however, the real-world incidence of this entity may be higher, especially now that ICIs are being used in nonclinical trial settings. In this review, we briefly introduce the biology of ICIs and the indications for ICI use in NSCLC and then discuss the epidemiology and clinical and radiologic manifestations of CIP. Next, we discuss management strategies for CIP, including the current consensus on management of steroid-refractory CIP. Given the nascent nature of this field, we highlight areas of uncertainty and emerging research questions in the burgeoning field of checkpoint inhibitor pulmonary toxicity.
journal_name
Chestjournal_title
Chestauthors
Suresh K,Naidoo J,Lin CT,Danoff Sdoi
10.1016/j.chest.2018.08.1048subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1416-1423issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(18)32336-5journal_volume
154pub_type
杂志文章,评审相关文献
CHEST文献大全abstract:OBJECTIVES:To report observations on preserved regular atrial electrical and mechanical systole during ventricular fibrillation (VF) and to quantitate blood flow generated by atrial contractions in this setting. METHODS:In 10 rats, right atrial pressure pulses were continuously recorded before and for an interval of 8...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.4.1118
更新日期:2000-04-01 00:00:00
abstract:STUDY OBJECTIVES:Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN:A retrospective case-control study. SETTING:Four Italian respir...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.121.1.189
更新日期:2002-01-01 00:00:00
abstract::There is now a new pathway and examination for sleep medicine, sponsored by the American Board of Internal Medicine, and a number of accredited sleep medicine fellowship programs through the Accreditation Council for Graduate Medical Education. This review takes an historical approach to discuss the process of educati...
journal_title:Chest
pub_type: 历史文章,杂志文章,评审
doi:10.1378/chest.10-0783
更新日期:2011-05-01 00:00:00
abstract::This report describes a 25-year follow-up of angiographically proven bilateral functioning Vineberg grafts. This represents the longest angiographic follow-up found in the literature. The relevance of these grafts in present-day revascularization procedures is discussed. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.3.824
更新日期:1997-03-01 00:00:00
abstract::This study was undertaken to determine if the production of pulsatile flow by the intra-aortic balloon pump during cardiopulmonary bypass has any beneficial effect on coronary flow, regional myocardial flow, myocardial metabolism, and left ventricular function. Thirty-six conditioned dogs were subjected to one hour of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.75.1.37
更新日期:1979-01-01 00:00:00
abstract::The gas exchange and hemodynamics were evaluated before, during, and after a two-hour period of prone position in 13 moderate-severe ARDS patients. Lung computerized tomography was obtained in both the supine and prone positions in two of these patients. Average arterial oxygenation improved after prone positioning (p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.1.103
更新日期:1988-07-01 00:00:00
abstract::In this study, pleural calcifications prevailing in the inhabitants of some villages and towns around Diyarbakir, a city in southeast Turkey, have been found to be caused by the inhalation of chrysotile asbestos, the mineral commonly used indiscriminately to paint the walls and floors of houses. There were no industri...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.70.1.43
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.11-1474
更新日期:2012-08-01 00:00:00
abstract::To validate color Doppler ultrasonography of renal arteries for the assessment of renal blood flow (RBF), we compared left and right RBF estimates and their sum (total RBF) by echo-Doppler with data obtained by iodine 123-123I-p-aminohippuric acid (PAH) scintigraphy in 19 patients with heart failure and 7 normal contr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.4.912
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2096
更新日期:2015-04-01 00:00:00
abstract::A review of the incidence and severity of hemolysis in the aortic prosthesis is presented. The noncloth-covered Starr-Edwards prosthetic series 1000, 1200, and 1260 had a 2 percent (1/54) incidence of anemia. The cloth-covered Starr-Edwards aortic prosthetic series 2300 was associated with anemia in 61 percent (28/46)...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.1.56
更新日期:1976-01-01 00:00:00
abstract::The effect of intravenous (IV) amiodarone (300 mg) on heart rate was investigated in 22 patients with acute myocardial infarction (18) or ischemia (4) and sinus tachycardia. There were 11 men and 11 women (age range, 48 to 83 years; mean, 63.5). Amiodarone IV slowed the mean heart rate from 109 +/- 14 beats/min to 94 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.3.584
更新日期:1988-09-01 00:00:00
abstract::Left hemorrhagic pleural effusion was the presenting sign of painless aortic dissecting aneurysm in two elderly hypertensive patients. Computed tomography (CT) of the chest revealed the aneurysmal dilatation of the thoracic aorta and an intimal flap connecting its descending part with the left pleural space. The patie...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.2.636
更新日期:1994-08-01 00:00:00
abstract::An 80-year-old man presented because of superficial head trauma sustained after falling from bed. On review of systems, he reported worsening dyspnea on exertion, nonproductive cough, and weight loss over the preceding 2 to 3 months. There was no report of chest pain or leg swelling. He had a past medical history of h...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2015.12.023
更新日期:2016-05-01 00:00:00
abstract::Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.2.193
更新日期:1983-02-01 00:00:00
abstract::An unusual site and cause of disabling inspiratory and expiratory airflow limitation mimicking fixed upper airway obstruction is reported in two patients with sarcoidosis who had stenosis of almost the entire lengths of both main bronchi. The observed flows were consistent with a cross sectional airway diameter of 3 m...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.2.244
更新日期:1985-08-01 00:00:00
abstract::Platypnea-orthodeoxia is an uncommon syndrome that may occur due to the postpneumonectomy state, cirrhosis of the liver, recurrent pulmonary embolism, and intracardiac shunting. We describe a patient who was found to have a positional change in desaturation after being admitted for dehydration. Workup revealed an atri...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.3.871
更新日期:2000-09-01 00:00:00
abstract::Mechanical ventilation was able to induce a decrease in cardiac output and regional blood flow, especially hepatic flow. Thus, hepatic elimination of drugs with a high hepatic-extraction ratio, which was linked to alteration in hepatic blood flow, could be reduced during mechanical ventilation. The aim of this work wa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.6.837
更新日期:1986-12-01 00:00:00
abstract::Continuous measurement of mixed venous oxygen saturation (SvO2) has been suggested as an adjunct in monitoring critically ill patients. We evaluated SvO2 monitoring in 24 patients suffering from complicated myocardial infarctions. Cardiac output and arterial lactate levels were measured when there were persistent 5 pe...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.3.607
更新日期:1989-03-01 00:00:00
abstract::Because of an emphasis on patient safety and recognition of the effectiveness of simulation as an educational modality across multiple medical specialties, use of health-care simulation (HCS) for medical education has become more prevalent. In this article, the effectiveness of simulation for areas important to the pr...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.07.011
更新日期:2019-12-01 00:00:00
abstract::We describe the first reported case (to our knowledge) of pulmonary granulomatosis caused by aspirated green tea. In this case, we found granulomatous alveolitis with lymph follicles, T lymphocytosis with predominantly CD8+ cells in the bronchoalveolar lavage fluids, positive serum precipitin and proliferative respons...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.1.308
更新日期:1994-07-01 00:00:00
abstract::Data on pulmonary function, with particular reference to flow-volumes, were obtained in 760 normal healthy Indians in Bombay, who had never smoked and who had no symptom or history of cardiorespiratory disease. Prediction equations were derived for spirometric parameters and for maximal expiratory flows. The maximal e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.6.852
更新日期:1986-06-01 00:00:00
abstract::This report describes a patient who developed gastric rupture as a result of post-extubation laryngeal edema and the use of a manual resuscitation bag. The association between oxygen administraton and gastric rupture is reviewed. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.3.324
更新日期:1979-09-01 00:00:00
abstract::A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual asso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1.111
更新日期:1980-07-01 00:00:00
abstract::Gastrointestinal complications requiring surgical correction following cardiopulmonary bypass most frequently involve the upper gastrointestinal tract. Surgical diseases of the colon are quite unusual in this setting. We recently performed cardiac surgery on three patients who developed acute diverticulitis requiring ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.5.756
更新日期:1986-05-01 00:00:00
abstract::Propofol, a new intravenous sedative agent, was investigated in 41 asthmatic patients undergoing day-case (outpatient) fiberoptic bronchoscopy. The study design was a randomized comparison between propofol and midazolam, which is a well-established intravenous sedative agent. The age, weight, and American Society of A...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.104.4.1029
更新日期:1993-10-01 00:00:00
abstract::A prospective study was done to compare four different methods of securing oral endotracheal tubes: adhesive tape (A), Twill tape (T), Twill tape with FlexBlue bite block (TFXB), and Velcro tie with FlexBlue (VFXB), used on sequential days. Thirty-six patients were enrolled for 136 patient-days and 18 had complete 4-d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.5.1537
更新日期:1993-11-01 00:00:00
abstract::Results of studies that use laboratory tests are often easy to interpret, because we are familiar with the units and how to interpret them. However, this is not the case when the results are presented as ORs, relative risks, correlation, or scores on an unfamiliar scale. This article explains these various indices of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-2473
更新日期:2012-03-01 00:00:00
abstract:STUDY OBJECTIVES:We set out to determine whether there is a difference in postoperative pain and recovery after the patient undergoes the axillary muscle-sparing incision (ie, muscle-sparing thoracotomy [MT]) vs the modified posterolateral incision (ie, posterolateral thoracotomy [PT]). DESIGN:Analysis of a database o...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.128.4.2664
更新日期:2005-10-01 00:00:00
abstract::We assessed qualitative and quantitative differences in surfactant lipid composition of bronchoalveolar lavage (BAL) fluid in patients with acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii (PC) pneumonia. Five normal volunteers and 27 patients with human immunodeficiency virus (HIV) infection underw...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1730
更新日期:1992-12-01 00:00:00