Usefulness of fine-needle aspiration biopsy of spleen in diagnosis of sarcoidosis.


:Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and in seven patients with extrinsic allergic alveolitis. No major complications occurred. The method provides a simple, safe, quick, and reliable way of producing evidence of a granulomatous process in patients with suspected sarcoidosis. The biopsy method can be used with advantage before application of more invasive techniques.






Selroos O,Koivunen E




Has Abstract


1983-02-01 00:00:00
















  • Antitussive effect of the GABA-agonist baclofen.

    abstract:BACKGROUND:gamma-Aminobutyric acid (GABA) is a central inhibitory neurotransmitter that also exists in peripheral tissues, including the lung. The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism, but has not been investigated in humans (to our knowledge). STUDY OBJECTI...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dicpinigaitis PV,Dobkin JB

    更新日期:1997-04-01 00:00:00

  • FVC to slow inspiratory vital capacity ratio: a potential marker for small airways obstruction.

    abstract:BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis oblitera...


    pub_type: 杂志文章


    authors: Cohen J,Postma DS,Vink-Klooster K,van der Bij W,Verschuuren E,Ten Hacken NH,Koëter GH,Douma WR

    更新日期:2007-10-01 00:00:00

  • The effects of flosequinan on hemodynamics and oxygen delivery in cor pulmonale.

    abstract::The hemodynamic effects of a new orally active vasodilator, flosequinan, were compared with placebo (single blind) over 24 h in eight patients with pulmonary hypertension secondary to severe chronic obstructive pulmonary disease. Mean pulmonary artery pressure was reduced by 5.1 (3.4, 6.7) mm Hg (mean 95 percent CI) (...


    pub_type: 临床试验,杂志文章


    authors: Elborn JS,Richardson G,Murphy P,MacMahon J

    更新日期:1992-10-01 00:00:00

  • Characteristics of airway inflammation and bronchodilator reversibility in COPD: a potential guide to treatment.

    abstract:STUDY OBJECTIVES:The management of stable patients with COPD depends on the severity of symptoms and airflow limitation. Regarding inflammation, corticosteroids are the only medications that are recommended for use, and only under restricted circumstances. Corticosteroids tend to undertreat or overtreat patients with C...


    pub_type: 杂志文章


    authors: Perng DW,Huang HY,Chen HM,Lee YC,Perng RP

    更新日期:2004-08-01 00:00:00

  • Acute changes in pulmonary artery pressures due to exercise and exposure to high altitude do not cause left ventricular diastolic dysfunction.

    abstract:BACKGROUND:Altitude-induced pulmonary hypertension has been suggested to cause left ventricular (LV) diastolic dysfunction due to ventricular interaction. In this study, we evaluate the effects of exercise- and altitude-induced increase in pulmonary artery pressures on LV diastolic function in an interventional setting...


    pub_type: 杂志文章,随机对照试验


    authors: Bernheim AM,Kiencke S,Fischler M,Dorschner L,Debrunner J,Mairbäurl H,Maggiorini M,Brunner-La Rocca HP

    更新日期:2007-08-01 00:00:00

  • The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis.

    abstract:BACKGROUND:Traditional diagnostic tests for pericardial tuberculosis (TB) are insensitive and often require long culture periods, and this has led to more emphasis being placed on biochemical tests such as the pericardial adenosine deaminase (ADA) test. However, controversy exists as to its diagnostic utility. In addit...


    pub_type: 杂志文章


    authors: Burgess LJ,Reuter H,Carstens ME,Taljaard JJ,Doubell AF

    更新日期:2002-09-01 00:00:00

  • Pulmonary practice profiles: Results of a practice performance survey.

    abstract:OBJECTIVES:Physician productivity, practice expense, resource allocation, facilities, staff, and malpractice are variables in medical practice profitability. The ongoing challenge of collecting reliable and consistent data created an opportunity in 2001 for the American College of Chest Physicians (ACCP) Practice Admin...


    pub_type: 杂志文章


    authors: Bauer JS,French KD

    更新日期:2006-09-01 00:00:00

  • Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension.

    abstract::Caveolae are cell plasma membrane microdomains implicated in organizing and concentrating many signaling molecules. In the lung, caveolae are in endothelium, smooth muscle, fibroblasts, and pneumocytes. Caveolin is the main structural protein of caveolae. Caveolin 1 is down-regulated in transformed cells and may be a ...


    pub_type: 杂志文章


    authors: Achcar RO,Demura Y,Rai PR,Taraseviciene-Stewart L,Kasper M,Voelkel NF,Cool CD

    更新日期:2006-03-01 00:00:00

  • Long-term survival and risk factors for recurrence in stage I non-small cell lung cancer patients with tumors up to 3 cm in maximum dimension.

    abstract:BACKGROUND:The purpose of this study was to evaluate patients with stage I non-small cell lung cancer (NSCLC) and tumors up to 3 cm in maximum dimension who underwent surgical resection on the revised TNM classification and to investigate the risk factors for recurrence. METHODS:Between 1994 and 2003, 713 consecutive ...


    pub_type: 杂志文章


    authors: Maeda R,Yoshida J,Ishii G,Hishida T,Aokage K,Nishimura M,Nishiwaki Y,Nagai K

    更新日期:2010-08-01 00:00:00

  • The acute effects of nasal positive pressure ventilation in patients with advanced cystic fibrosis.

    abstract:OBJECTIVE:To evaluate the acute effects of noninvasive positive pressure ventilation (NPPV) in patients with stable chronic respiratory failure secondary to cystic fibrosis. PATIENTS:Eight patients (29+/-5 years of age) with severe airflow limitation (mean FEV1, 24+/-3% predicted) and chronic respiratory failure (PaO2...


    pub_type: 杂志文章


    authors: Granton JT,Kesten S

    更新日期:1998-04-01 00:00:00

  • Factors associated with the treatment of latent tuberculosis infection among health-care workers at a midwestern teaching hospital.

    abstract:STUDY OBJECTIVE:To assess factors associated with initiating therapy and compliance with treatment for latent tuberculosis infection among health-care workers with positive tuberculin skin test results. DESIGN:Prospective cohort study. SETTING:An urban midwestern teaching hospital in St. Louis, MO. STUDY POPULATION:...


    pub_type: 杂志文章


    authors: Shukla SJ,Warren DK,Woeltje KF,Gruber CA,Fraser VJ

    更新日期:2002-11-01 00:00:00

  • Measurement of surface temperature in lung cancer.

    abstract::We measured the surface temperature of the tumors in 27 patients with primary lung cancer, using a flexible bronchofiberscope and a thermometer made from chromel-constantan. The thermometer was inserted into the aspiration channel of the bronchofiberscope, and temperature was studied under bronchofiberscopic located i...


    pub_type: 杂志文章


    authors: Ohgimi T,Akiyama S,Shimokata K

    更新日期:1982-01-01 00:00:00

  • Feasibility of the detection of the sentinel lymph node in peripheral non-small cell lung cancer with radio isotopic and blue dye techniques.

    abstract:STUDY OBJECTIVES:The objective of this study was to evaluate the feasibility of the sentinel lymph node (SLN) biopsy in peripheral clinically stage I or II non-small cell lung cancer (NSCLC) using (99m)Tc colloid and a hand-held gamma detection probe, associated with a blue dye technique. DESIGN:Prospective study. SE...


    pub_type: 杂志文章


    authors: Tiffet O,Nicholson AG,Khaddage A,Prévot N,Ladas G,Dubois F,Goldstraw P

    更新日期:2005-02-01 00:00:00

  • An unusual case of pneumorrhachis following resection of lung carcinoma.

    abstract::We report an unusual case of a patient with a bronchopleural-subcutaneous fistula that occurred 3 years following a lobectomy and en bloc chest wall resection for carcinoma. Following a sudden resolution of subcutaneous emphysema, an epidural air collection developed. Spontaneous pneumorrhachis is a previously unrepor...


    pub_type: 杂志文章


    authors: Ristagno RL,Hiratzka LF,Rost RC Jr

    更新日期:2002-05-01 00:00:00

  • A comprehensive, national survey of spirometry in Spain: current bottlenecks and future directions in primary and secondary care.

    abstract:BACKGROUND:We aimed to evaluate the availability and practice of spirometry, training of technicians, and spirometer features and maintenance in Spain in both primary care (PC) and secondary care (SC) centers. METHODS:We used a nationwide, cross-sectional, 36-item telephone survey of health-care centers in Spain to ta...


    pub_type: 杂志文章


    authors: López-Campos JL,Soriano JB,Calle M,Encuesta de Espirometría en España (3E) Project.

    更新日期:2013-08-01 00:00:00

  • Endoscopic ultrasound/fine-needle aspiration diagnosis of a malignant subcarinal lymph node in a patient with lung cancer and a negative positron emission tomography scan.

    abstract::Transesophageal, endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) and positron emission tomography (PET) scanning are new modalities for staging non-small cell lung cancer (NSCLC), the roles of which are still being defined. A 78-year-old man with a right lower lobe (RLL) mass and mediastinal adenopathy...


    pub_type: 杂志文章


    authors: Rosenberg JM,Perricone A,Savides TJ

    更新日期:2002-09-01 00:00:00

  • Enhanced responses to aerosolized bronchodilator therapy in asthma using respiratory maneuvers.

    abstract::To determine if respiratory maneuvers may enhance the response to inhaled bronchodilator drugs, we evaluated the bronchodilator responses when isoproterenol was: inhaled as a bolus high (80 percent VC) compared to low (20 percent VC) lung volumes, and inhaled as a single 800 microgram dose compared to four 200 microgr...


    pub_type: 杂志文章


    authors: Riley DJ,Liu RT,Edelman NH

    更新日期:1979-11-01 00:00:00

  • Diaphragmatic dysfunction in siblings with hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease).

    abstract::Hereditary motor and sensory neuropathy (Charcot-Marie-Tooth disease) is characterized by chronic degeneration of peripheral nerves and roots, resulting in distal muscle atrophy, beginning in the feet and legs and later involving the hands. The association of this disease with diaphragmatic dysfunction has not been re...


    pub_type: 杂志文章


    authors: Chan CK,Mohsenin V,Loke J,Virgulto J,Sipski ML,Ferranti R

    更新日期:1987-04-01 00:00:00

  • Maximal sniff mouth pressure compared with maximal inspiratory pressure in acute respiratory failure.

    abstract::Inspiratory muscle strength most often is better reflected by sniff Pes than PImax against occlusion. Furthermore, sniff Pes can be estimated noninvasively by the measurement of sniff Pmo in normal subjects and in patients with respiratory muscle weakness. The aim of this study was to compare sniff Pmo and P.PImax to ...


    pub_type: 杂志文章


    authors: Héritier F,Perret C,Fitting JW

    更新日期:1991-07-01 00:00:00

  • Inflammatory mediators in BAL fluid as markers of evolving pneumonia in leukocytopenic patients.

    abstract:STUDY OBJECTIVES:Pneumonia during chemotherapy-induced leukocytopenia is a major cause of overall treatment failure in patients with hematologic malignancies. To improve outcome in these high-risk patients, early diagnosis of pulmonary infiltrates and institution of adequate antimicrobial treatment are mandatory. To id...


    pub_type: 杂志文章


    authors: Kiehl MG,Ostermann H,Thomas M,Birkfellner T,Kienast J

    更新日期:1997-11-05 00:00:00

  • Paradoxical trough effects of triple therapy with budesonide/formoterol and tiotropium bromide on pulmonary function outcomes in COPD.

    abstract:BACKGROUND:Lowest receptor occupancy for a drug occurs at trough prior to the next dose. Previous studies have focused on the effects of triple therapy at peak dose intervals using forced expiratory maneuvers. Impulse oscillometry (IOS) and body plethysmography (PLETH) are more sensitive than spirometry to assess inhal...


    pub_type: 杂志文章,随机对照试验


    authors: Williamson PA,Short PM,Clearie KL,Vaidyanathan S,Fardon TC,Howaniec LJ,Lipworth BJ

    更新日期:2010-09-01 00:00:00

  • Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? The Dutch CNSLD Study Group. The Dutch Chronic Nonspecific Lung Disease Study Groups.

    abstract:BACKGROUND:The institution of inhaled corticosteroids is generally advocated for effective treatment of patients with asthma. It is yet unknown what is the best time to start inhaled corticosteroid therapy and especially whether delayed introduction is harmful. PHASE 1: In a previous study in patients with asthma and C...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Overbeek SE,Kerstjens HA,Bogaard JM,Mulder PG,Postma DS

    更新日期:1996-07-01 00:00:00

  • Post-ICU mechanical ventilation at 23 long-term care hospitals: a multicenter outcomes study.

    abstract:STUDY OBJECTIVES:This multicenter study was undertaken to characterize the population of ventilator-dependent patients admitted to long-term care hospitals (LTCHs) with weaning programs, and to report treatments, complications, weaning outcome, discharge disposition, and survival in these patients. DESIGN:Observationa...


    pub_type: 杂志文章,多中心研究


    authors: Scheinhorn DJ,Hassenpflug MS,Votto JJ,Chao DC,Epstein SK,Doig GS,Knight EB,Petrak RA,Ventilation Outcomes Study Group.

    更新日期:2007-01-01 00:00:00

  • Effect of weight loss on the ECG of normotensive morbidly obese patients.

    abstract:BACKGROUND:Morbid obesity produces a variety of ECG alterations, including leftward shifts of the P-wave, QRS, and T-wave axes; disproportionately high frequencies of low QRS voltage; left ventricular hypertrophy and left atrial abnormality; and a high frequency of T-wave flattening in the inferior and lateral leads. T...


    pub_type: 杂志文章


    authors: Alpert MA,Terry BE,Hamm CR,Fan TM,Cohen MV,Massey CV,Painter JA

    更新日期:2001-02-01 00:00:00

  • Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.

    abstract::To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were ...


    pub_type: 杂志文章


    authors: Katz JA,Kraemer RW,Gjerde GE

    更新日期:1985-10-01 00:00:00

  • The Burden of Community-Acquired Pneumonia Requiring Admission to ICU in the United States.

    abstract:BACKGROUND:A paucity of studies have assessed the epidemiology of community-acquired pneumonia (CAP) that require ICU admission. We conducted a study on this group of patients with the primary objective of defining the incidence, epidemiology, and mortality rate of CAP in the ICUs in Louisville, Kentucky. The secondary...


    pub_type: 杂志文章


    authors: Cavallazzi R,Furmanek S,Arnold FW,Beavin LA,Wunderink RG,Niederman MS,Ramirez JA

    更新日期:2020-09-01 00:00:00

  • Atrial function during cardiac arrest caused by ventricular fibrillation.

    abstract:OBJECTIVES:To report observations on preserved regular atrial electrical and mechanical systole during ventricular fibrillation (VF) and to quantitate blood flow generated by atrial contractions in this setting. METHODS:In 10 rats, right atrial pressure pulses were continuously recorded before and for an interval of 8...


    pub_type: 杂志文章


    authors: Pernat A,Weil MH,Sun S,Tang W,Yamaguchi H,Bisera J

    更新日期:2000-04-01 00:00:00

  • Mucoid impaction of upper lobe bronchi in the absence of proximal bronchiectasis.

    abstract::Mucoid impaction is a complication of asthma and is frequently recurrent in patients with allergic bronchopulmonary aspergillosis (ABPA). This report describes a patient with asthma and recurrent bilateral well-circumscribed densities on chest roentgenogram in the absence of ABPA. Recognition of this clinical presenta...


    pub_type: 杂志文章


    authors: Anderson WM

    更新日期:1990-10-01 00:00:00

  • Bitolterol mesylate (WIN 32784) aerosol. A new long-acting bronchodilator with reduced chronotropic effects.

    abstract::Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. Th...


    pub_type: 临床试验,杂志文章


    authors: Kass I,Mingo TS

    更新日期:1980-08-01 00:00:00

  • Recovery of the ventilatory and upper airway muscles and exercise performance after type A botulism.

    abstract::We studied six patients with type A botulism to determine the degree of initial respiratory compromise and to quantitate the time course and extent of recovery of the ventilatory and upper airway muscles and exercise performance. The VM weakness was identified in all patients early after botulism. Upper airway muscle ...


    pub_type: 杂志文章


    authors: Wilcox PG,Morrison NJ,Pardy RL

    更新日期:1990-09-01 00:00:00