Inhaled diuretics attenuate acid-induced cough in children with asthma.

Abstract:

:To evaluate the effect of inhaled diuretics, furosemide and amiloride, on cough induced by acid inhalation challenge in asthmatic children, a double-blind, randomized, placebo-controlled study was conducted. On separate days, 12 asthmatic children (10.3 +/- 0.7 [SEM] years) underwent acetic acid (AD) inhalation challenge after inhalation of furosemide (10 mg/m2 of body) amiloride (0.3 mg/m2 of body), or placebo (0.9% saline solution). Bronchoconstriction was not observed after administration of furosemide and amiloride. Both inhaled furosemide and amiloride exerted a protective effect against AA-induced cough in asthmatic children (p < 0.01 and p < 0.05, respectively), while there was little correlation between the individual protective potency of furosemide and amiloride against AA-induced cough (rs = 0.344, p = 0.255). These results demonstrate that both furosemide and amiloride can attenuate AA-induced cough, although, this protective effect of inhaled diuretics may not necessarily be dependent on Na(+)-K(+)-Cl- cotransporter or Na+ channel in airway epithelial cells.

journal_name

Chest

journal_title

Chest

authors

Mochizuki H,Shimizu T,Morikawa A,Kuroume T

doi

10.1378/chest.107.2.413

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

413-7

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)34971-6

journal_volume

107

pub_type

临床试验,杂志文章,随机对照试验

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