Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception.

Abstract:

OBJECTIVE:The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma. PATIENTS AND METHODS:Subjects with asthma (n = 116) underwent baseline spirometry and lung volume measurement followed by high-dose methacholine challenge testing (MCT) [maximum decrease in FEV(1) of 50% from baseline]. Dyspnea intensity (Borg scale) was measured after each dose of methacholine. Qualitative descriptors of breathlessness and functional residual capacity (FRC) were measured at the doses nearest to the provocative concentration of methacholine causing a 20% fall in FEV (PC(20)) and at the highest dose of methacholine (maximum response). RESULTS:FEV(1) decreased by 24.7 +/- 0.7% (mean +/- SEM) at the dose nearest to PC(20) and by 46.1 +/- 1.1% at maximum response. Inspiratory capacity decreased by 0.62 +/- 0.04 L at the dose nearest to PC(20) and 1.06 +/- 0.06 L at maximum response. The descriptor clusters "inspiratory difficulty," "chest tightness," "unsatisfied inspiration," and "work" were selected at the dose nearest to PC(20) but were more frequently selected at maximum response (p < 0.0001). Individuals who reported chest tightness at maximum response had greater airflow obstruction and higher FRC (percentage of predicted) than those who did not report chest tightness. CONCLUSIONS:Four dominant qualities of dyspnea in asthma (inspiratory difficulty, chest tightness, unsatisfied inspiration, and work) were reported early in the course of MCT and evolved in parallel, becoming more prevalent at maximum response. Significant DH accompanied even mild bronchoconstriction during MCT in asthma, making it difficult to separate mechanisms of chest tightness from other dominant respiratory sensations.

journal_name

Chest

journal_title

Chest

authors

Lougheed MD,Fisher T,O'Donnell DE

doi

10.1378/chest.130.4.1072

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

1072-81

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)51142-2

journal_volume

130

pub_type

杂志文章

相关文献

CHEST文献大全
  • A 32-Year-Old Man With HIV Infection, Pleural Effusions, and Lymphadenopathy.

    abstract:CASE PRESENTATION:A 32-year-old man presented with fever, nonproductive cough, diffuse lymphadenopathy, and polyarticular pain for 2 weeks. His medical history included HIV diagnosed 10 years ago, anal intraepithelial neoplasia, Kaposi sarcoma, and herpes simplex virus-2 infection. The patient was not receiving antiret...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.05.013

    authors: Xian JZ,Cherian SV,Golardi N,Estrada-Y-Martin RM

    更新日期:2018-11-01 00:00:00

  • High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis.

    abstract:BACKGROUND:Histopathologic evidence of fibrosis on surgical lung biopsy has been associated with reduced survival in patients with hypersensitivity pneumonitis (HP). Changes of pulmonary fibrosis detected on CT may also correlate with prognosis in patients with HP. METHODS:We identified 69 consecutive patients with HP...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.07-3005

    authors: Hanak V,Golbin JM,Hartman TE,Ryu JH

    更新日期:2008-07-01 00:00:00

  • Effects of long-term aerosol pentamidine for Pneumocystis carinii prophylaxis on pulmonary function.

    abstract:OBJECTIVE:The purpose of the study was to evaluate the long-term effects of aerosolized pentamidine (AP) on the pulmonary function of HIV-positive individuals receiving AP for Pneumocystis carinii pneumonia (PCP) prophylaxis. DESIGN:A retrospective analysis of serial pulmonary function tests (PFTs) performed on a coho...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.3.742

    authors: Wei CC,Pack LL,Chan CK

    更新日期:1998-09-01 00:00:00

  • Cyclophosphamide in the treatment of pulmonary diseases: survey of use, training, and practitioner knowledge base.

    abstract:OBJECTIVE:To assess pulmonologists' use, training in the use, and knowledge base of the drug cyclophosphamide. DESIGN:Survey through questionnaire. Testing of knowledge base before and after instructional conference. PARTICIPANTS AND METHODS:Pulmonologists (94 attendings, 31 fellows), selected randomly at the 1996 an...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.5.1159

    authors: Cozzi PJ,Hall JB

    更新日期:1999-11-01 00:00:00

  • Etiologic factors of chronic bronchitis in dairy farmers. Case control study in the Doubs region of France.

    abstract::Relationships were investigated between chronic bronchitis and plant dust exposure assessed by quantification of barn threshing and cattle foddering and chronic bronchitis and acute respiratory syndromes after plant mold dust exposure. Two groups of male dairy farmers were studied in the Doubs region, France: 197 with...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.2.417

    authors: Dalphin JC,Pernet D,Dubiez A,Debieuvre D,Allemand H,Depierre A

    更新日期:1993-02-01 00:00:00

  • Respiratory muscle training for respiratory deficits in neurodegenerative disorders: a systematic review.

    abstract:BACKGROUND:Studies of the impact of respiratory muscle training (RMT) on central neurodegenerative pathologies have been aimed at improving pulmonary function. However, there is no certainty about the effectiveness of RMT in patients affected by these groups of disorders. The purpose of this review was to assess the ev...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-1442

    authors: Reyes A,Ziman M,Nosaka K

    更新日期:2013-05-01 00:00:00

  • Mechanical ventilation may not be essential for initial cardiopulmonary resuscitation.

    abstract:BACKGROUND:In a rodent model of cardiac arrest and resuscitation in which the inspired gas mixture was enriched with oxygen, resuscitability and survival were unaffected by positive pressure ventilation. In the present study, in a larger animal model, tidal volumes generated during precordial compression and with spont...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.3.821

    authors: Noc M,Weil MH,Tang W,Turner T,Fukui M

    更新日期:1995-09-01 00:00:00

  • Cytomegaloviral infection presenting as a solitary pulmonary nodule.

    abstract::Cytomegaloviral infection presenting in an immunologically compromised host as a solitary pulmonary nodule has not previously been reported. A patient with a renal transplant and with no pulmonary symptoms was noted to have a single nodule on a chest roentgenogram. At autopsy, this proved to be secondary to cytomegalo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.2.220

    authors: Ravin CE,Smith GW,Ahern MJ,McLoud T,Putman C,Milchgrub S

    更新日期:1977-02-01 00:00:00

  • Ischemia and reperfusion during intermittent coronary occlusion in man. Studies of electrocardiographic changes and CPK release.

    abstract::The course of 357 balloon inflations performed during 38 angioplasties for single-vessel coronary artery disease was prospectively studied using continuous ECG recording. Ischemic ECG changes appeared during 91 percent of the inflations at a mean of 20 +/- 8 seconds after inflation and resolved in 97 percent of those ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.2.386

    authors: Mager A,Sclarovsky S,Wurtzel M,Menkes H,Strasberg B,Rechavia E

    更新日期:1991-02-01 00:00:00

  • Validation of the Exhaled Breath Temperature Measure: Reference Values in Healthy Subjects.

    abstract:BACKGROUND:Exhaled breath temperature (EBT) is a new noninvasive method for the study of inflammatory respiratory diseases with a potential to reach clinical practice. However, few studies are available regarding the validation of this method, and they were mainly derived from small, pediatric populations; thus, the ra...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.11.013

    authors: Carpagnano GE,Foschino-Barbaro MP,Crocetta C,Lacedonia D,Saliani V,Zoppo LD,Barnes PJ

    更新日期:2017-04-01 00:00:00

  • Nd-YAG laser vs bronchoscopic electrocautery for palliation of symptomatic airway obstruction: a cost-effectiveness study.

    abstract:STUDY OBJECTIVE:To evaluate the cost effectiveness of the Nd-YAG laser and bronchoscopic electrocautery for palliation in patients with symptomatic tumor obstruction. DESIGN:A retrospective study. SETTING:Bronchoscopy unit of a university hospital. PATIENTS AND INTERVENTION:Thirty-one consecutive patients with inope...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.4.1108

    authors: Boxem Tv,Muller M,Venmans B,Postmus P,Sutedja T

    更新日期:1999-10-01 00:00:00

  • Chemical pneumonitis due to exposure to bromine compounds.

    abstract::A 60-year-old laboratory technician developed pulmonary infiltrates consistent with chemical pneumonitis following accidental exposure to a mixture of hydrogen bromide and phosphorus tribromide. A protracted clinical course ensued consistent with bronchiolitis obliterans. These problems may have been avoided if the po...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.1.208

    authors: Kraut A,Lilis R

    更新日期:1988-07-01 00:00:00

  • Pulmonary Nodules: A Small Problem for Many, Severe Distress for Some, and How to Communicate About It.

    abstract::Every year, millions of patients are diagnosed with pulmonary nodules, and as increasing numbers of people undergo lung cancer screening, even more patients will be found to have a nodule. The vast majority of patients cannot benefit from the detection of a pulmonary nodule because most are benign. Accordingly, it is ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.10.013

    authors: Slatore CG,Wiener RS

    更新日期:2018-04-01 00:00:00

  • Socioeconomic status and lung function.

    abstract::Poverty is a major social problem in the United States and throughout much of the world. Poverty and the broader term socioeconomic status (SES) are important determinants of overall health status and many pulmonary diseases. The purpose of this study was to review the medical literature from the past 20 years address...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.07-1405

    authors: Hegewald MJ,Crapo RO

    更新日期:2007-11-01 00:00:00

  • Spontaneous pneumothorax. Long-term results with tetracycline pleurodesis.

    abstract::The aim of this prospective study was to determine the rate of recurrence for spontaneous pneumothorax (SP) after tetracycline pleurodesis (TCP), using that of observation, tube thoracostomy alone, and thoracotomy as references. From 1985 to the end of 1991, 78 patients were treated with tetracycline pleurodesis and 1...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.106.2.347

    authors: Alfageme I,Moreno L,Huertas C,Vargas A,Hernandez J,Beiztegui A

    更新日期:1994-08-01 00:00:00

  • The First Second Timed vital capacity and the course of obstructive lung diseases.

    abstract::Previous work has shown that with increasing airway obstruction in chronic obstructive pulmonary disease, the decrement in the maximum midexpiratory flow (MMEF) is exponential. Therefore, with severe obstructive disease the decrease in the MMEF as the disease progresses is difficult to discern. This work points out th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.1.81

    authors: Sobol BJ,Emirgil C

    更新日期:1977-07-01 00:00:00

  • Diagnosis and treatment of cystic fibrosis. An update.

    abstract::Cystic fibrosis is the most common fatal inherited disease of Caucasians. At present, cystic fibrosis accounts for most cases of chronic progressive pulmonary disease and for many other clinical features in the first three decades of life. Thus, it is a challenge to both pediatricians and internists, particularly ches...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/s0012-3692(16)62421-2

    authors: Davis PB,di Sant'Agnese PA

    更新日期:1984-06-01 00:00:00

  • Chronic persistent cough. Experience in diagnosis and outcome using an anatomic diagnostic protocol.

    abstract::Irwin and co-workers have designed an anatomic approach to the diagnosis and treatment of cough. In their hands, diagnosis was consistently determined and treatment successful almost without exception, if sustained. We reviewed the results of a similar approach in 139 consecutive and unselected patients referred to pu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.4.723

    authors: Poe RH,Harder RV,Israel RH,Kallay MC

    更新日期:1989-04-01 00:00:00

  • Predicting effective continuous positive airway pressure.

    abstract:PURPOSE:The purpose of this study was to compare the pressure required to abolish apneas as predicted from a previously derived algorithm (Ppred) with the true effective pressure (Peff) determined during a continuous positive airway pressure (CPAP) titration study. SETTING:Sleep clinic of a university hospital. METHO...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.4.1061

    authors: Oliver Z,Hoffstein V

    更新日期:2000-04-01 00:00:00

  • Spontaneous dissection of the ascending aorta diagnosed by two-dimensional echocardiography.

    abstract::In two patients with acute dissection of the ascending aorta, the diagnosis was made with two-dimensional echocardiography and confirmed by aortography. The echocardiograms localized the intimal flap and false channel in both cases. Although clinical evaluation and indicated radiologic studies remain the primary modal...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.5.587

    authors: Rubenson DS,Fowles RE,Miller DC,Guthaner DF,Popp RL

    更新日期:1981-11-01 00:00:00

  • Pneumonia in allogenic and autologous bone marrow recipients. A retrospective study.

    abstract::Pulmonary infections, which frequently occur during the early and late period following bone marrow transplantation for hematologic malignancies, are associated with significant morbidity and mortality. In this study the incidence, the infectious causes of pneumonia and the mortality related to pneumonia in 130 alloge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.2.371

    authors: Gentile G,Micozzi A,Girmenia C,Iori AP,Donati PP,Capria S,Martino P

    更新日期:1993-08-01 00:00:00

  • The spectrum of building-related airway disorders: difficulty in retrospectively diagnosing building-related asthma.

    abstract:INTRODUCTION:The specific causes and mechanism(s) for asthma occurring among occupants of non-residential buildings with poor indoor air quality are not known, but allergic and nonallergic processes are possible explanations METHODS:Repeated indoor air quality measurements were made while employees were working in a b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.3.1720

    authors: Brooks SM,Spaul W,McCluskey JD

    更新日期:2005-09-01 00:00:00

  • Asbestos-related rounded atelectasis. Radiologic and mineralogic data in 23 cases.

    abstract::A retrospective study was conducted in 23 subjects with previous occupational exposure to asbestos and exhibiting rounded atelectasis (RA) on high-resolution computed tomography scan (HRCT scan) to evaluate the retention of asbestos bodies (ABs) using light microscopy in the bronchoalveolar lavage (BAL) fluid or lung ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.2.477

    authors: Voisin C,Fisekci F,Voisin-Saltiel S,Ameille J,Brochard P,Pairon JC

    更新日期:1995-02-01 00:00:00

  • Further observations on the electrophysiologic effects of oral amiodarone therapy.

    abstract::A case is presented of a reversible intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormalities. His bundle recordings showed an atrial tachycardia with intermittent exit block and greatly prolonged BH and HV intervals (40 and 100 ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.82.1.117

    authors: Santinelli V,Chiariello M,Ambrosio G,Stanislao M,Condorelli M

    更新日期:1982-07-01 00:00:00

  • Cardiopulmonary exercise testing in children: an individualized protocol for workload increase.

    abstract:OBJECTIVES:To investigate the feasibility of individualized workload increments, as used in adults, for exercise testing in children; and to investigate whether this individualized protocol makes it possible to satisfy the usual criteria for maximal exercise (clinical exhaustion, predicted maximum heart rate [HRmax], o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.1.81

    authors: Karila C,de Blic J,Waernessyckle S,Benoist MR,Scheinmann P

    更新日期:2001-07-01 00:00:00

  • Hospitalizations for pulmonary reactions following nitrofurantoin use.

    abstract::Acute pulmonary illness compatible with previously described nitrofurantoin toxicity and requiring hospitalization occurred three times among 16,101 first courses of therapy with nitrofurantoin. One case of fatal pulmonary fibrosis was ascribed to long-term use of nitrofurantoin among 742 observed recipients of ten or...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.3.512

    authors: Jick SS,Jick H,Walker AM,Hunter JR

    更新日期:1989-09-01 00:00:00

  • Echocardiographic findings after tricuspid valvectomy.

    abstract::Resection of the tricuspid valve without prosthetic replacement has successfully been performed in patients with tricuspid valvular endocarditis. Using M-mode, two-dimensional, and Doppler echocardiograms, we studied four patients who underwent tricuspid valvectomy. All patients had previous history of intravenous dru...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.87.5.668

    authors: Friedman G,Kronzon I,Nobile J,Cohen ML,Winer HE

    更新日期:1985-05-01 00:00:00

  • Evaluation of variable mandibular advancement appliance for treatment of snoring and sleep apnea.

    abstract:OBJECTIVE:To evaluate an adjustable mandibular positioning appliance for treatment of snoring and sleep apnea. METHODS:One hundred thirty-four patients with baseline apnea/hypopnea index (AHI) of 37 +/- 28 events/h (mean +/- SD) received the appliance. The efficacy of the appliance was assessed by the following invest...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.6.1511

    authors: Pancer J,Al-Faifi S,Al-Faifi M,Hoffstein V

    更新日期:1999-12-01 00:00:00

  • Inhalation challenge with bovine dander allergens: who needs it?

    abstract:STUDY OBJECTIVES:To identify which tests would be useful in selecting patients for a specific inhalation challenge with bovine dander allergens (bSIC). DESIGN:A prospective study. SETTING:A university hospital. PATIENTS:Thirty-seven dairy farmers with a clinical suspicion of occupational asthma due to bovine allerge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.1.383

    authors: Koskela H,Taivainen A,Tukiainen H,Chan HK

    更新日期:2003-07-01 00:00:00

  • Inhaled corticosteroid dose response using domiciliary exhaled nitric oxide in persistent asthma: the FENOtype trial.

    abstract:BACKGROUND:International guidelines advocate a standard approach to asthma management for all, despite its heterogeneity. "Personalized" treatment of inflammatory asthma phenotypes confers superior benefits. We wished to evaluate dose response to inhaled corticosteroids (ICSs) in patients with asthma with an elevated f...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.12-1310

    authors: Anderson WJ,Short PM,Williamson PA,Lipworth BJ

    更新日期:2012-12-01 00:00:00