More lung cancer but better survival. Implications of secular trends in "necropsy surprise" rates.


:In previous research, we have demonstrated the value of using necropsy "surprise" lung cancer cases, in those in whom lung cancer was not suspected during life, to estimate the size and composition of the "reservoir" of undetected lung cancer in the general population. The current research was done to determine the characteristics and consequences of secular changes over time in the composition of the lung cancer "reservoir." The results suggest that further advances in diagnostic technology will enhance detection during life of the large "reservoir" of resectable lung cancer, particularly in women. With the increased detection of these reservoir cases during life, the statistical occurrence rates for lung cancer will seem to increase, but survival rates will seem to improve because more of the detected cases will be resectable.






Chan CK,Wells CK,McFarlane MJ,Feinstein AR




Has Abstract


1989-08-01 00:00:00
















  • Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.

    abstract:BACKGROUND:It is unknown if the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS:We reviewed records from 177 patients with HP...


    pub_type: 杂志文章


    authors: Mooney JJ,Elicker BM,Urbania TH,Agarwal MR,Ryerson CJ,Nguyen MLT,Woodruff PG,Jones KD,Collard HR,King TE Jr,Koth LL

    更新日期:2013-08-01 00:00:00

  • Pathologic bronchial vasculature in a case of massive hemoptysis due to chronic bronchitis.

    abstract::The cause of bleeding in a patient with recurrent massive hemoptysis was not apparent after bronchoscopy and gross examination of the lobectomy specimen. Histologic submission of all major bronchi uncovered dilated, tortuous bronchial arteries just below the bronchial mucosa with sites of both current and healing arte...


    pub_type: 杂志文章


    authors: Spark RP,Sobonya RE,Armbruster RJ,Marco JD,Rotkis TC

    更新日期:1991-02-01 00:00:00

  • Bronchial adenoma. Clinicopathologic study and results of treatment.

    abstract::Among 1,700 primary tumors of the lung, there were 53 cases of bronchial adenoma (3.1 percent); 38 (72 percent) of the 53 were typical carcinoids, and the remaining 15 were of a higher grade of malignant neoplasm. There was a slight predominance of female patients, and the age of greatest incidence was between 30 and ...


    pub_type: 杂志文章


    authors: de Lima R

    更新日期:1980-01-01 00:00:00

  • Ciliary beat frequency in human bronchi and bronchioles.

    abstract:STUDY OBJECTIVE:This study aimed to determine the differences between ciliary beat frequencies of respiratory ciliated cells from peripheral bronchioles and from proximal bronchi in humans. DESIGN:Measurements were made from resected lungs. Ciliated cells were harvested by brushing the mucosa of each site immediately ...


    pub_type: 杂志文章


    authors: Clary-Meinesz C,Mouroux J,Huitorel P,Cosson J,Schoevaert D,Blaive B

    更新日期:1997-03-01 00:00:00

  • Bilateral phrenic paralysis in a patient with systemic lupus erythematosus.

    abstract::Respiratory manifestations of systemic lupus erythematosus (SLE) are frequent. They include respiratory muscle abnormalities, which have been implicated in the pathogenesis of the "shrinking lung syndrome" (SLS). We report the case of a patient with this syndrome, in whom diaphragmatic paralysis due to demyelinating p...


    pub_type: 杂志文章


    authors: Hardy K,Herry I,Attali V,Cadranel J,Similowski T

    更新日期:2001-04-01 00:00:00

  • Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation.

    abstract:PURPOSES:Patients receiving prolonged acute mechanical ventilation (PAMV), although comprising a third of all mechanical ventilation (MV) patients, consume two-thirds of all the resources allocated to MV, and their numbers are projected to double by 2020. By virtue of their prolonged hospital length of stay (median LOS...


    pub_type: 杂志文章


    authors: Zilberberg MD,Nathanson BH,Sadigov S,Higgins TL,Kollef MH,Shorr AF

    更新日期:2009-09-01 00:00:00

  • Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole.

    abstract::Itraconazole is a new orally active antifungal triazole with impressive activity against Aspergillus spp. Six patients with allergic bronchopulmonary aspergillosis (ABPA), aged 14 to 49 years, were treated with oral itraconazole (200 mg twice daily) for a mean of 3.9 months (range, one to six months; three patients co...


    pub_type: 杂志文章


    authors: Denning DW,Van Wye JE,Lewiston NJ,Stevens DA

    更新日期:1991-09-01 00:00:00

  • The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period.

    abstract:BACKGROUND:Studies evaluating the dose of epinephrine required to optimize return of spontaneous circulation and survival after CPR have shown that doses greater than recommended by advanced cardiac life support (ACLS) improve coronary perfusion pressure and short-term resuscitation rates. Since survival has not improv...


    pub_type: 临床试验,杂志文章


    authors: Rivers EP,Wortsman J,Rady MY,Blake HC,McGeorge FT,Buderer NM

    更新日期:1994-11-01 00:00:00

  • Pre- and postoperative pulmonary function abnormalities in coronary artery revascularization surgery.

    abstract::Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...


    pub_type: 杂志文章


    authors: Braun SR,Birnbaum ML,Chopra PS

    更新日期:1978-03-01 00:00:00

  • Nonsurgical treatment of Histoplasma endocarditis involving a bioprosthetic valve.

    abstract::Endocardial involvement associated with disseminated histoplasmosis has been infrequently documented, especially among patients with prosthetic valves. The therapeutic approach to these patients is also not yet clearly defined. A 54-year-old man with prosthetic valve endocarditis due to histoplasmosis was successfully...


    pub_type: 杂志文章,评审


    authors: Kanawaty DS,Stalker MJ,Munt PW

    更新日期:1991-01-01 00:00:00

  • The relationship between obesity and craniofacial structure in obstructive sleep apnea.

    abstract:STUDY OBJECTIVE:To evaluate the interaction between craniofacial structure and obesity in male patients with obstructive sleep apnea (OSA). DESIGN:Retrospective analysis of a cohort of OSA patients. The relationships between neck circumference (NC), body mass index, apnea severity, and craniofacial and upper airway so...


    pub_type: 杂志文章


    authors: Ferguson KA,Ono T,Lowe AA,Ryan CF,Fleetham JA

    更新日期:1995-08-01 00:00:00

  • The relationship between left ventricular function assessed by multigated radionuclide test and cardiopulmonary exercise test in patients with ischemic heart disease.

    abstract:STUDY OBJECTIVES:To compare the oxygen pulse curve (O(2)P-C) as measured during cardiopulmonary exercise testing (CPET) with left ventricular (LV) ejection fraction (LVEF) rest-exercise response as measured by multigated equilibrium (99m)Tc radionuclide cineangiography (MUGA) in patients with different degrees of ische...


    pub_type: 杂志文章


    authors: Klainman E,Fink G,Lebzelter J,Krelbaumm T,Kramer MR

    更新日期:2002-03-01 00:00:00

  • Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea: a 12-week, open-label study.

    abstract:STUDY OBJECTIVES:The purpose of this 12-week study was to evaluate the efficacy and safety of adjunct modafinil to treat excessive sleepiness in patients with obstructive sleep apnea (OSA) who experience residual sleepiness despite regular nasal continuous positive airway pressure (nCPAP) use. DESIGN:Twelve-week, open...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Schwartz JR,Hirshkowitz M,Erman MK,Schmidt-Nowara W

    更新日期:2003-12-01 00:00:00

  • Physician-diagnosed COPD global initiative for chronic obstructive lung disease stage IV in Ostersund, Sweden: Patient characteristics and estimated prevalence.

    abstract:BACKGROUND:The prevalence of COPD is estimated to 4 to 14%. According to the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD is divided into four stages. Patients with stage IV disease (very severe) have FEV1 < 30% of predicted values and/or respiratory insufficiency. The few studies that exist ...


    pub_type: 杂志文章


    authors: Stenfors N

    更新日期:2006-09-01 00:00:00

  • Colloid osmotic pressure in infants with hyaline membrane disease.

    abstract::Colloid osmotic pressure (COP) was measured serially in 81 critically ill neonates with hyaline membrane disease (HMD) during the first five days of life, and these changes were correlated with the birth weight, gestational age, serum protein level, clinical status, and outcome. Colloid osmotic pressure correlated bet...


    pub_type: 杂志文章


    authors: Bhat R,Malalis L,Shukla A,Vidyasagar D

    更新日期:1983-05-01 00:00:00

  • Post-test probability of asthma following methacholine challenge.

    abstract::Using recently published data, a nomogram was constructed to estimate the likelihood of asthma following methacholine challenge. Based on Bayes' theorem, the nomogram makes use of the sensitivity and specificity of methacholine challenge to calculate the post-test probability of asthma once the physician makes a deter...


    pub_type: 杂志文章


    authors: Gilbert R,Auchincloss JH Jr

    更新日期:1990-03-01 00:00:00

  • Pentoxifylline rescue preserves lung function in isolated canine lungs injured with phorbol myristate acetate.

    abstract:OBJECTIVE:We hypothesized that pentoxifylline, administered after phorbol myristate acetate (PMA), would diminish the severity of lung injury. SETTING:Animal research laboratory. DESIGN:Comparative study. SUBJECTS:Mongrel dogs (n = 33). INTERVENTIONS:Baseline measurements were obtained from the isolated blood-perfu...


    pub_type: 杂志文章


    authors: Creamer KM,McCloud LL,Fisher LE,Ehrhart IC

    更新日期:2001-06-01 00:00:00

  • Cross-sectional echocardiographic detection of aortic ring abscess in bacterial endocarditis.

    abstract::The diagnosis of aortic ring abscess by cross-sectional echocardiography has not been reported. In this paper, a case of bacterial endocarditis of the aortic valve extending to the aortic ring and the mitral valve is reported. The role of cross-sectional echocardiography in defining the anatomic distortion of the aort...


    pub_type: 杂志文章


    authors: Mardelli TJ,Ogawa S,Hubbard FE,Dreifus LS,Meixell LL

    更新日期:1978-11-01 00:00:00

  • Trends in physician-diagnosed asthma prevalence in Manitoba between 1980 and 1990.

    abstract::We attempted to assess recent changes in the prevalence of physician-diagnosed asthma and the possible influence of diagnostic exchange on these trends. The routinely collected data of the provincial Health Insurance Plan (physicians' claims) were used to determine the annual prevalence of physician-diagnosed asthma i...


    pub_type: 杂志文章


    authors: Manfreda J,Becker AB,Wang PZ,Roos LL,Anthonisen NR

    更新日期:1993-01-01 00:00:00

  • Right chest electrocardiographic patterns in normal subjects.

    abstract::Right-sided chest lead ECGs (V3R to V6R) were recorded in 110 normal male subjects who were between the ages of 17 and 22 years old (mean, 17.9 years). The prevalence of the rS pattern decreased from V3R (89 percent) to V6R (37 percent). However, the opposite was the case for the rSr pattern (10 percent in V3R and 36 ...


    pub_type: 杂志文章


    authors: Tan CC,Hiew TM,Chia BL

    更新日期:1990-03-01 00:00:00

  • Persistence of lung function abnormalities despite sustained success of percutaneous mitral valvotomy: the need for an early indication.

    abstract:AIMS:We assessed early and long-term pulmonary function changes after percutaneous balloon mitral valvotomy (PBMV). METHODS AND RESULTS:Mitral area, lung function, and exercise capacity were evaluated before, immediately after, and 3 months, 6 months, and 12 months after successful PBMV in 24 patients. PBMV resulted i...


    pub_type: 杂志文章


    authors: Gómez-Hospital JA,Cequier A,Romero PV,Cañete C,Ugartemendia C,Iràculis E,Esplugas E

    更新日期:2005-01-01 00:00:00

  • Rapid diagnosis of primary influenza pneumonia.

    abstract::Primary influenza pneumonia is a disease of high mortality. Differentiation between a bacterial and viral etiology for the pulmonary infiltrates frequently presents a diagnostic dilemma. Rapid diagnosis is essential; and once established, the patient requires careful supportive therapy. This report describes two patie...


    pub_type: 杂志文章


    authors: Bogart DB,Liu C,Ruth WE,Kerby GR,Williams CH

    更新日期:1975-10-01 00:00:00

  • Dyphylline aerosol attenuates antigen-induced bronchoconstriction in experimental canine asthma.

    abstract::This study compared the bronchodilator effect in experimental canine asthma of dyphylline administered by aerosol and intravenous routes in doses producing equivalent concentrations of the drug in the plasma. Pulmonary resistance (RL) was calculated from simultaneous measurements of pressure and flow during fixed-volu...


    pub_type: 杂志文章


    authors: Hirshman CA,Lawyer C,Downes H,Farbood A,Rodgers R,Gerber N

    更新日期:1981-04-01 00:00:00

  • Comparative Effectiveness and Safety of LABA-LAMA vs LABA-ICS Treatment of COPD in Real-World Clinical Practice.

    abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...


    pub_type: 杂志文章


    authors: Suissa S,Dell'Aniello S,Ernst P

    更新日期:2019-06-01 00:00:00

  • The effect on expiratory flow rates of smoking three cigarettes in rapid succession.

    abstract::The effect of smoking three cigarettes in rapid succession on maximal and partial expiratory flow rates was studied in ten healthy smokers. The mean decrease in maximal midexpiratory flow and partial midexpiratory and end-expiratory flow was statistically significant. The response was maximal after the first cigarette...


    pub_type: 杂志文章


    authors: Hamosh P,Taveira Da Silva AM

    更新日期:1977-11-01 00:00:00

  • Complications of corticosteroid therapy in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia.

    abstract::We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of cort...


    pub_type: 杂志文章


    authors: Lambertus MW,Goetz MB,Murthy AR,Mathisen GE

    更新日期:1990-07-01 00:00:00

  • Diagnosis and treatment of cystic fibrosis. An update.

    abstract::Cystic fibrosis is the most common fatal inherited disease of Caucasians. At present, cystic fibrosis accounts for most cases of chronic progressive pulmonary disease and for many other clinical features in the first three decades of life. Thus, it is a challenge to both pediatricians and internists, particularly ches...


    pub_type: 杂志文章,评审


    authors: Davis PB,di Sant'Agnese PA

    更新日期:1984-06-01 00:00:00

  • Noninvasive positive-pressure ventilation facilitates tracheal extubation after laryngotracheal reconstruction in children.

    abstract::Tracheal extubation after laryngotracheal reconstruction in children may be complicated by postoperative tracheal edema and pulmonary dysfunction. The replacement of a tracheal tube in this situation may exacerbate the existing injury to the tracheal mucosa, complicating subsequent attempts at tracheal extubation. We ...


    pub_type: 杂志文章


    authors: Hertzog JH,Siegel LB,Hauser GJ,Dalton HJ

    更新日期:1999-07-01 00:00:00

  • Angioimmunoblastic lymphadenopathy presenting as superior vena caval obstruction.

    abstract::A 60-year-old man presented with features of superior vena cava (SVC) obstruction. On evaluation, he was diagnosed as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). SVC obstruction due to AILD, to our knowledge, has not been described. ...


    pub_type: 杂志文章


    authors: Sanghvi S,Kothari AS,Hathi BC,Sharma RG

    更新日期:1991-12-01 00:00:00

  • Prevalence of pulmonary hypertension in limited and diffuse scleroderma.

    abstract:STUDY OBJECTIVES:To characterize the prevalence of undiagnosed pulmonary hypertension in patients with limited and diffuse scleroderma. DESIGN:Prospective cross-sectional study. SETTING:University-based outpatient clinic. PATIENTS:Thirty-four consecutive patients with limited (n = 29) or diffuse (n = 5) scleroderma ...


    pub_type: 杂志文章


    authors: Battle RW,Davitt MA,Cooper SM,Buckley LM,Leib ES,Beglin PA,Tischler MD

    更新日期:1996-12-01 00:00:00