Abstract:
:Almitrine improves blood gas values in patients with COPD, primarily through better ventilation-perfusion matching. The improvement comes largely from a vasomotor effect of the drug. The vasomotor mechanism is unknown. We suspected that decreased distensibility of the large pulmonary arteries was one probable effect of the drug. If present, reduced distensibility would explain many of the hemodynamic alterations produced by almitrine. To test this idea, we measured the diameter of the right pulmonary artery during systole and diastole both before and after almitrine administration in nine patients who were undergoing pulmonary cineangiography. Our calculations of the distensibility of the right pulmonary artery showed that almitrine caused a 60 percent decrease. This significant alteration in the stiffness of the large pulmonary arteries can account for the rise in systolic pressure, a change that would be expected to redistribute pulmonary blood flow upwards and thereby improve ventilation-perfusion balance.
journal_name
Chestjournal_title
Chestauthors
Herve P,Musset D,Simonneau G,Wagner W Jr,Duroux Pdoi
10.1378/chest.96.3.572subject
Has Abstractpub_date
1989-09-01 00:00:00pages
572-7issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(15)46069-6journal_volume
96pub_type
杂志文章相关文献
CHEST文献大全abstract::COPD is a significant public health challenge, notably set to become the third leading cause of death and fifth leading cause of chronic disability worldwide by the next decade. Skeletal muscle impairment is now recognized as a disabling, extrapulmonary consequence of COPD that is associated with reduced quality of li...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2015.11.021
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The prevalence of COPD is estimated to 4 to 14%. According to the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD is divided into four stages. Patients with stage IV disease (very severe) have FEV1 < 30% of predicted values and/or respiratory insufficiency. The few studies that exist ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.3.666
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::Patients with COPD often have reduced inspiratory muscle strength and endurance as well as poor exercise tolerance. Increased inspiratory work during sleep (probably due to increased upper airway resistance) may further strain these compromised respiratory muscles in COPD patients. We hypothesized that nasal continuou...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.106.4.1100
更新日期:1994-10-01 00:00:00
abstract:CASE PRESENTATION:A 76-year-old nonsmoking woman visiting from Honduras for the last 6 months with no known medical history originally presented to the ED complaining of abdominal pain. While in the ED, an incidental right middle lobe collapse was found on CT abdomen scan. Review of systems was positive for a chronic p...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.10.030
更新日期:2019-05-01 00:00:00
abstract::We report the cases of two lung transplant recipients (one heart-lung and one single lung) who eventually developed cytomegalovirus (CMV) pneumonitis after documentation of increasing CMV DNA titers in sequential bronchoalveolar lavage (BAL) specimens by polymerase chain reaction (PCR) amplification. To our knowledge,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.1.93
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Current functional assessments do not allow a reliable assessment of small airways, which are a major site of disease in COPD. Single-breath washout (SBW) tests are feasible and reproducible methods for evaluating small airway disease. Their relevance in COPD remains unknown. METHODS:We performed a cross-se...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.chest.2016.05.019
更新日期:2016-11-01 00:00:00
abstract::The unusual occurrence of non-infected submitral and aortic aneurysms developing sequentially in an adult prompted us to review the pathogenesis of congenital aneurysms adjacent to the aortic and mitral valves. The findings support the suggestion that subvalvular aneurysms, like aortic sinus aneurysms, are a result of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.82.3.334
更新日期:1982-09-01 00:00:00
abstract::In previous research, we have demonstrated the value of using necropsy "surprise" lung cancer cases, in those in whom lung cancer was not suspected during life, to estimate the size and composition of the "reservoir" of undetected lung cancer in the general population. The current research was done to determine the ch...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.291
更新日期:1989-08-01 00:00:00
abstract::Long-term response to vasodilator therapy was assessed in six patients with PPH. Following an acute trial, each patient was restudied after (1) two months of drug administration, (2) one month of abstinence from therapy, and (3) an additional two months of therapy. Three of six patients had no long-term reduction of P...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.6.1185
更新日期:1989-06-01 00:00:00
abstract::Because PGE1 previously has been reported to increase survival of patients with ARDS, we evaluated physiologic effects and side effects of PGE1 in a prospective open-label study of patients with ARDS. Seventeen patients with ARDS who did not have significant renal or hepatic dysfunction received PGE1 by continuous cen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.3.684
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To assess, by systematic review, the efficacy and safety of recombinant tissue plasminogen activator (rt-PA) in the treatment of lower extremity deep venous thrombosis (DVT). A secondary objective is to assess the optimal dose and route of administration of rt-PA. METHODS:Included studies were randomized, co...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.119.2.572
更新日期:2001-02-01 00:00:00
abstract::The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.5.779
更新日期:1986-11-01 00:00:00
abstract::To assess the effects of intravenous aminophylline on the sinus node, 12 patients with clinical and Holter monitor-documented sick sinus syndrome were studied (1) during the control state, (2) after pharmacologic autonomic blockade and (3) 5 min after intravenous administration of aminophylline. The effects of aminoph...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.4.887
更新日期:1991-04-01 00:00:00
abstract::A 66-year-old woman was cared for at two referral institutions following a witnessed cardiac arrest in a local emergency department. Despite aggressive initial care, she failed to regain consciousness during a 28-day course. Based on an erroneous neurologic diagnosis of anoxic encephalopathy, pessimism regarding likel...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-0471
更新日期:2008-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine whether the likelihood of lung nodule calcification can be predicted from nodule size as measured on a chest radiograph (CXR). DESIGN:Retrospective review of CXRs of patients with lung nodules < or =1 cm in size detected on CT scanning. CT images were used to identify calcifications and t...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.118.3.610
更新日期:2000-09-01 00:00:00
abstract::The severity of pulmonary hypertension was evaluated by right cardiac catheterization in 89 patients with stable chronic obstructive pulmonary disease, both at rest and during maximum treadmill exercise. Thirty-one patients were found to have pulmonary hypertension at rest, defined as a mean pulmonary arterial pressur...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.2.185
更新日期:1986-08-01 00:00:00
abstract::On the occasion of this Fourth World Conference on Lung Cancer, I am privileged to present the opening keynote address. This presentation has been sponsored by the Ontario Cancer Treatment and Research Foundation. In 1952, the Foundation established an annual lectureship in memory of one of their prominent physicians....
journal_title:Chest
pub_type: 临床试验,历史文章,杂志文章,评审
doi:10.1378/chest.89.4.200s
更新日期:1986-04-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the outcome of Legionnaires disease (LD) in patients with and without HIV infection. DESIGN:Retrospective review of clinical charts. SETTING:Six hundred-bed university hospital. PATIENTS:We studied the clinical findings of 64 patients without HIV and 15 patients with HIV. Patients with a ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.2.543
更新日期:2003-08-01 00:00:00
abstract::Chronic heart failure (CHF) is a complex syndrome affecting many body systems. Body wasting (ie, cardiac cachexia) is a serious complication of CHF long known but little investigated. Although no specific diagnostic criteria have been established, we have suggested that cardiac cachexia be defined on the basis of the ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.115.3.836
更新日期:1999-03-01 00:00:00
abstract::A case of double-orifice mitral valve in a 16-year-old Japanese boy is presented. Two-dimensional echocardiography, including transesophageal approach, showed two approximately equal orifices with three papillary muscles. Color Doppler echocardiography showed a mild mitral regurgitation from both orifices. No other ca...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.104.5.1616
更新日期:1993-11-01 00:00:00
abstract::A young man presented to us with an asymptomatic ovoid mass which appeared to be in the right major fissure. The roentgenographic appearance of the lesion was that of a pseudotumor. The computerized tomography scan suggested tissue density leading to exploration. At surgery, we found the mass to be a portion of liver ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.2.346
更新日期:1980-08-01 00:00:00
abstract::We report two patients with non-conventional thyroiditis whose chief complaint was chronic persistent cough. Cough was attributed to thyroiditis only after extensive diagnostic evaluations failed to uncover another cause and only after cough and thyroiditis disappeared simultaneously with suppressive therapy for the l...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.81.3.386
更新日期:1982-03-01 00:00:00
abstract::Platypnea-orthodeoxia is an uncommon syndrome that may occur due to the postpneumonectomy state, cirrhosis of the liver, recurrent pulmonary embolism, and intracardiac shunting. We describe a patient who was found to have a positional change in desaturation after being admitted for dehydration. Workup revealed an atri...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.3.871
更新日期:2000-09-01 00:00:00
abstract::We report an unusual case of a patient with a bronchopleural-subcutaneous fistula that occurred 3 years following a lobectomy and en bloc chest wall resection for carcinoma. Following a sudden resolution of subcutaneous emphysema, an epidural air collection developed. Spontaneous pneumorrhachis is a previously unrepor...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.5.1712
更新日期:2002-05-01 00:00:00
abstract::A patient with ulcerative colitis had extensive upper zone pulmonary disease while taking sulfasalazine. Pulmonary function tests showed progressive restrictive and obstructive disease. Lung biopsy showed bronchiolitis obliterans and chronic interstitial pneumonia or fibrosing alveolitis with a mild eosinophilic infil...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.81.6.766
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:The new GOLD (Global Initiative for Chronic Obstructive Lung Disease) strategy recommends use of the COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) scale to assess symptoms in COPD against "risk" as assessed by spirometry or exacerbation frequency. We aimed to determine the concordanc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.13-0161
更新日期:2013-10-01 00:00:00
abstract::The factors that contribute to the symptoms of breathlessness and fatigue, and that limit exercise capacity in patients with chronic heart failure are poorly understood. Recent evidence suggests that the major mechanism is not related to central hemodynamics but to a reduction of skeletal muscle mass and diminished bl...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.101.5_supplement.330s
更新日期:1992-05-01 00:00:00
abstract::A 13-year-old patient named Jahi McMath was determined to be dead by neurologic criteria following cardiopulmonary arrest and resuscitation at a hospital in Oakland, California. Her family did not agree that she was dead and refused to allow her ventilator to be removed. The family's attorney stated in the media that ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2227
更新日期:2015-04-01 00:00:00
abstract::The goal of this article is to provide an update on recent changes to current procedural terminology codes used for billing physician services for mechanical ventilation in chronic care facilities. In addition to billing information, background data relevant to prolonged mechanical ventilation are reviewed. Topics cov...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-0656
更新日期:2008-02-01 00:00:00