Abstract:
:The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can participate in the growth of an immobile hemostatic plug. How this is accomplished is the subject of this review.
journal_name
Chestjournal_title
Chestauthors
Brass LFdoi
10.1378/chest.124.3_suppl.18ssubject
Has Abstractpub_date
2003-09-01 00:00:00pages
18S-25Sissue
3 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(15)31754-2journal_volume
124pub_type
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