Thrombin and platelet activation.

Abstract:

:The accumulation of thrombin at sites of vascular injury provides one of the chief means for recruiting platelets into a growing hemostatic plug. Studies completed over the past 10 years show that platelet responses to thrombin are mediated by a subset of G protein-coupled receptors known as protease-activated receptors. These receptors are activated on cleavage by thrombin, initiating the intracellular signaling events needed to transform mobile, nonadhesive platelets into cells that can participate in the growth of an immobile hemostatic plug. How this is accomplished is the subject of this review.

journal_name

Chest

journal_title

Chest

authors

Brass LF

doi

10.1378/chest.124.3_suppl.18s

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

18S-25S

issue

3 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)31754-2

journal_volume

124

pub_type

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