Definition of cutoff values for the hypoxia test used for preflight testing in young children with neonatal chronic lung disease.

Abstract:

BACKGROUND:The hypoxia test can be performed to identify potential hypoxia that might occur in an at-risk individual during air travel. In 2004, the British Thoracic Society increased the hypoxia test cutoff guideline from 85 to 90% in young children. The aim of this study was to investigate how well the cutoff values of 85% and 90% discriminated between healthy children and those with neonatal chronic lung disease (nCLD). METHODS:We performed a prospective, interventional study in young children with nCLD who no longer required supplemental oxygen and healthy control subjects. A hypoxia test (involving the administration of 14% oxygen for 20 min) was performed in all children, and the nadir in pulse oximetric saturation (Spo(2)) recorded. RESULTS:Hypoxia test results were obtained in 34 healthy children and 35 children with a history of nCLD. Baseline Spo(2) in room air was unable to predict which children would "fail" the hypoxia test. In those children < 2 years of age, applying a cutoff value of 90% resulted in 12 of 24 healthy children and 14 of 23 nCLD children failing the hypoxia test (p = 0.56), whereas a cutoff value of 85% was more discriminating, with only 1 of 24 healthy children and 6 of 23 nCLD children failing the hypoxia test (p = 0.048). CONCLUSION:In the present study, using a hypoxia test limit of 90% did not discriminate between healthy children and those with nCLD. A cutoff value of 85% may be more appropriate in this patient group. The clinical relevance of fitness to fly testing in young children remains to be determined.

journal_name

Chest

journal_title

Chest

authors

Martin AC,Verheggen M,Stick SM,Stavreska V,Oostryck J,Wilson AC,Hall GL

doi

10.1378/chest.07-1198

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

914-9

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)49679-5

journal_volume

133

pub_type

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