Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.


:To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were compared with one continuous-flow, 5-L reservoir-bag system (flow of 60 L/min to maintain positive airway pressure). It was concluded that demand-flow CPAP delivery systems vary widely in the amount of additional work required of a patient. When a lung model is used, some demand-flow systems perform as well as, or better than, a continuous-flow reservoir-bag system.






Katz JA,Kraemer RW,Gjerde GE




Has Abstract


1985-10-01 00:00:00
















  • Silicone thorax due to a ruptured breast implant.

    abstract::A woman with a history of bilateral mastectomy and silicone implants for fibrocystic disease and a history of atrial septal defect repair presented with pleural nodules on a chest radiograph. A thorascopic biopsy performed for possible mesothelioma demonstrated chronic inflammation and focal pleural fibrosis due to a ...


    pub_type: 杂志文章


    authors: Levine RL,Allen TC,Cartwright J Jr,Cagle PT

    更新日期:2005-05-01 00:00:00

  • Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure.

    abstract:STUDY OBJECTIVES:There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in clinical CO poisoning (range, 36 to 131 min, respectively). Other rep...


    pub_type: 杂志文章,评审


    authors: Weaver LK,Howe S,Hopkins R,Chan KJ

    更新日期:2000-03-01 00:00:00

  • Bronchial hyperreactivity in patients with moderate pulmonary circulation overload.

    abstract::The clinical course of congestive heart failure (CHF) and mitral valve stenosis (MVS) is accompanied by episodes of dyspnea, wheezing, and cough, symptoms also observed in patients with bronchial hyperreactivity. However, it is still controversial whether bronchial hyperreactivity is demonstrable in patients with chro...


    pub_type: 杂志文章


    authors: Brunnée T,Graf K,Kastens B,Fleck E,Kunkel G

    更新日期:1993-05-01 00:00:00

  • Perioperative predictors of acute cholecystitis after cardiovascular surgery.

    abstract:OBJECTIVE:To determine the incidence, diagnostic features, and perioperative predictors of acute cholecystitis after cardiovascular surgery. DESIGN:Inception cohort study. SETTING:A tertiary care 54-bed cardiothoracic ICU. PATIENTS:All patients admitted to an ICU after cardiovascular surgery during a 42-month period...


    pub_type: 杂志文章


    authors: Rady MY,Kodavatiganti R,Ryan T

    更新日期:1998-07-01 00:00:00

  • Trends in physician-diagnosed asthma prevalence in Manitoba between 1980 and 1990.

    abstract::We attempted to assess recent changes in the prevalence of physician-diagnosed asthma and the possible influence of diagnostic exchange on these trends. The routinely collected data of the provincial Health Insurance Plan (physicians' claims) were used to determine the annual prevalence of physician-diagnosed asthma i...


    pub_type: 杂志文章


    authors: Manfreda J,Becker AB,Wang PZ,Roos LL,Anthonisen NR

    更新日期:1993-01-01 00:00:00

  • Patterns of Use of Adjunctive Therapies in Patients With Early Moderate to Severe ARDS: Insights From the LUNG SAFE Study.

    abstract:BACKGROUND:Adjunctive strategies are an important part of the management of ARDS. However, their application in clinical practice remains inconsistent. RESEARCH QUESTION:We wished to determine the frequency and patterns of use of adjunctive strategies in patients with moderate to severe ARDS (Pao2/Fio2 [P/F ratio] < 1...


    pub_type: 杂志文章


    authors: Duggal A,Rezoagli E,Pham T,McNicholas BA,Fan E,Bellani G,Rubenfeld G,Pesenti AM,Laffey JG,LUNG SAFE Investigators and the ESICM Trials Group.

    更新日期:2020-06-01 00:00:00

  • Trazodone-related exercise-induced nonsustained ventricular tachycardia.

    abstract::A 79-year-old woman in the course of a syncope evaluation is shown to have a trazodone-related cardiac arrhythmia confirmed by drug rechallenge. This nontricyclic antidepressant should be considered as potentially arrhythmogenic despite its generally favorable cardiovascular profile. ...


    pub_type: 杂志文章


    authors: Vitullo RN,Wharton JM,Allen NB,Pritchett EL

    更新日期:1990-07-01 00:00:00

  • COPD-OSA Overlap Syndrome: Evolving Evidence Regarding Epidemiology, Clinical Consequences, and Management.

    abstract::COPD and OSA are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of coexisting OSA in that the increased lung volumes and low BMI associated with...


    pub_type: 杂志文章,评审


    authors: McNicholas WT

    更新日期:2017-12-01 00:00:00

  • Targeted Fluid Minimization Following Initial Resuscitation in Septic Shock: A Pilot Study.

    abstract:BACKGROUND:IV fluid represents a basic therapeutic intervention for septic shock. Unfortunately, the optimal administration of IV fluid to maximize patient outcomes and prevent complications is largely unknown. METHODS:Patients with septic shock admitted to the medical ICUs of Barnes-Jewish Hospital (January to Decemb...


    pub_type: 杂志文章,随机对照试验


    authors: Chen C,Kollef MH

    更新日期:2015-12-01 00:00:00

  • Detection of unstable angina by 99m technetium pyrophosphate myocardial scintigraphy.

    abstract::99mTechnetium stannous pyrophosphate has been shown to accumulate in acutely infarcted myocardium. To determine if the isotope is also taken up by severely ischemic, but not necrotic myocardium, we performed myocardial scintigraphic studies in 17 patients with chest pains. Seven of the patients satisfied conventional ...


    pub_type: 杂志文章


    authors: Abdulla AM,Canedo MI,Cortez BC,McGinnis KD,Wilhelm SK

    更新日期:1976-02-01 00:00:00

  • Genetics of COPD and emphysema.

    abstract::COPD is a highly prevalent disorder that results from the interplay of genetic susceptibility and environmental exposures. Over the past 2 decades, significant technological advances have been made in genetic investigations of complex diseases, yet limited progress has been made in the identification of additional COP...


    pub_type: 杂志文章,评审


    authors: Wan ES,Silverman EK

    更新日期:2009-09-01 00:00:00

  • Evaluation of right ventricular performance with a right ventricular ejection fraction thermodilution catheter and MRI in patients with pulmonary hypertension.

    abstract:STUDY OBJECTIVES:We sought to compare catheter studies using a right ventricular ejection fraction (REF) catheter together with echocardiography and MRI in patients with pulmonary hypertension. PATIENTS AND METHODS:We compared hemodynamic findings, echocardiography, and MRI studies in 16 patients with pulmonary hypert...


    pub_type: 杂志文章


    authors: Hoeper MM,Tongers J,Leppert A,Baus S,Maier R,Lotz J

    更新日期:2001-08-01 00:00:00

  • The impact of associated diabetic retinopathy on stroke and severe bleeding risk in diabetic patients with atrial fibrillation: the loire valley atrial fibrillation project.

    abstract:BACKGROUND:Diabetes mellitus is recognized as a stroke risk factor in atrial fibrillation (AF). Patients with diabetes with retinopathy have an increased risk for systemic cardiovascular complications, and severe diabetic retinopathy predisposes to ocular bleeding. We hypothesized that patients with diabetes, retinopat...


    pub_type: 杂志文章


    authors: Lip GYH,Clementy N,Pierre B,Boyer M,Fauchier L

    更新日期:2015-04-01 00:00:00

  • Socioeconomic status and lung function.

    abstract::Poverty is a major social problem in the United States and throughout much of the world. Poverty and the broader term socioeconomic status (SES) are important determinants of overall health status and many pulmonary diseases. The purpose of this study was to review the medical literature from the past 20 years address...


    pub_type: 杂志文章,评审


    authors: Hegewald MJ,Crapo RO

    更新日期:2007-11-01 00:00:00

  • Fluid therapy in resuscitated sepsis: less is more.

    abstract::Fluid infusion may be lifesaving in patients with severe sepsis, especially in the earliest phases of treatment. Following initial resuscitation, however, fluid boluses often fail to augment perfusion and may be harmful. In this review, we seek to compare and contrast the impact of fluids in early and later sepsis; sh...


    pub_type: 杂志文章,评审


    authors: Durairaj L,Schmidt GA

    更新日期:2008-01-01 00:00:00

  • Cough in Ambulatory Immunocompromised Adults: CHEST Expert Panel Report.

    abstract:BACKGROUND:Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However, it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating cond...


    pub_type: 杂志文章,评审


    authors: Rosen MJ,Ireland B,Narasimhan M,French C,Irwin RS,CHEST Expert Cough Panel.

    更新日期:2017-11-01 00:00:00

  • Intermediate alpha1-antitrypsin deficiency resulting from a null gene (M-phenotype).

    abstract::The presence of a null gene for alpha1-antitrypsin was detected in a family study by the inheritance of intermediate antitrypsin deficiency in association with a normal (PiM) phenotypic pattern. The proband, a 42-year-old man (M-phenotype), was a cigarette smoker and had physiologic evidence of pulmonary emphysema. Th...


    pub_type: 杂志文章


    authors: Lieberman J,Gaidults L,Schleissner LA

    更新日期:1976-10-01 00:00:00

  • Silica-induced pleural disease: an unusual case mimicking malignant mesothelioma.

    abstract::A 57-year-old man with a history of exposure to silica for 32 years presented with pleural thickening of the lower lobe of the left lung and a chronic right-sided pleural effusion without any radiographic evidence of parenchymal nodules in either lung. Light microscopic examination of a left visceral pleural biopsy sp...


    pub_type: 杂志文章,评审


    authors: Zeren EH,Colby TV,Roggli VL

    更新日期:1997-11-05 00:00:00

  • The relation of body mass index to asthma, chronic bronchitis, and emphysema.

    abstract:BACKGROUND:Recent studies have suggested a relationship between asthma and obesity. Despite these reports, the effect of being underweight or overweight as a risk factor for airway obstructive diseases (AODs) is not clear. OBJECTIVES:To determine whether a relation of body mass index (BMI) to asthma, chronic bronchiti...


    pub_type: 杂志文章


    authors: Guerra S,Sherrill DL,Bobadilla A,Martinez FD,Barbee RA

    更新日期:2002-10-01 00:00:00

  • Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension.

    abstract::Caveolae are cell plasma membrane microdomains implicated in organizing and concentrating many signaling molecules. In the lung, caveolae are in endothelium, smooth muscle, fibroblasts, and pneumocytes. Caveolin is the main structural protein of caveolae. Caveolin 1 is down-regulated in transformed cells and may be a ...


    pub_type: 杂志文章


    authors: Achcar RO,Demura Y,Rai PR,Taraseviciene-Stewart L,Kasper M,Voelkel NF,Cool CD

    更新日期:2006-03-01 00:00:00

  • Sex differences in response to tadalafil in pulmonary arterial hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a progressive disease with high rates of morbidity and mortality. Current therapies improve symptoms, functional capacity, and, in select cases, survival. Little is known about patient factors that may predict the likelihood of patient-important, clinically relevant r...


    pub_type: 杂志文章,随机对照试验


    authors: Mathai SC,Hassoun PM,Puhan MA,Zhou Y,Wise RA

    更新日期:2015-01-01 00:00:00

  • Radionuclide localization of massive pulmonary hemorrhage.

    abstract::Lung scans with technetium sulfur colloid were performed in ten patients with life-threatening hemoptysis and nondiagnostic chest roentgenograms. Localized deposition of radionuclide was demonstrated in five of the six patients who were studied during active bleeding. These abnormalities were confirmed bronchoscopical...


    pub_type: 杂志文章


    authors: Haponik EF,Rothfeld B,Britt EJ,Bleecker ER

    更新日期:1984-08-01 00:00:00

  • PREPARED: Preparation for Angiography in Renal Dysfunction: a randomized trial of inpatient vs outpatient hydration protocols for cardiac catheterization in mild-to-moderate renal dysfunction.

    abstract:BACKGROUND:IV hydration before and after cardiac catheterization is effective in preventing contrast-associated renal dysfunction for patients with mild-to-moderate renal insufficiency, but necessitates overnight hospital admission. We tested an outpatient oral precatheterization hydration strategy in comparison with o...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Taylor AJ,Hotchkiss D,Morse RW,McCabe J

    更新日期:1998-12-01 00:00:00

  • Bilateral phrenic paralysis in a patient with systemic lupus erythematosus.

    abstract::Respiratory manifestations of systemic lupus erythematosus (SLE) are frequent. They include respiratory muscle abnormalities, which have been implicated in the pathogenesis of the "shrinking lung syndrome" (SLS). We report the case of a patient with this syndrome, in whom diaphragmatic paralysis due to demyelinating p...


    pub_type: 杂志文章


    authors: Hardy K,Herry I,Attali V,Cadranel J,Similowski T

    更新日期:2001-04-01 00:00:00

  • Immediate hypersensitivity to tuberculin. In vivo and in vitro studies.

    abstract::Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occur...


    pub_type: 杂志文章


    authors: Tarlo SM,Day JH,Mann P,Day MP

    更新日期:1977-01-01 00:00:00

  • Effects of prostaglandin E1 on oxygen delivery and consumption in patients with the adult respiratory distress syndrome. Results from the prostaglandin E1 multicenter trial. The Prostaglandin E1 Study Group.

    abstract::We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: pl...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Silverman HJ,Slotman G,Bone RC,Maunder R,Hyers TM,Kerstein MD,Ursprung JJ

    更新日期:1990-08-01 00:00:00

  • Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease.

    abstract::Collagenases in bronchoalveolar lavage fluid (BALF) of patients with bronchiectasis and healthy subjects were characterized using specific functional and immunologic assays. The BAL fluid contained interstitial collagenase and collagenolytic proteinases of bacterial origin. Collagenase activities, obtained after organ...


    pub_type: 杂志文章


    authors: Sepper R,Konttinen YT,Ding Y,Takagi M,Sorsa T

    更新日期:1995-06-01 00:00:00

  • Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? The Dutch CNSLD Study Group. The Dutch Chronic Nonspecific Lung Disease Study Groups.

    abstract:BACKGROUND:The institution of inhaled corticosteroids is generally advocated for effective treatment of patients with asthma. It is yet unknown what is the best time to start inhaled corticosteroid therapy and especially whether delayed introduction is harmful. PHASE 1: In a previous study in patients with asthma and C...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Overbeek SE,Kerstjens HA,Bogaard JM,Mulder PG,Postma DS

    更新日期:1996-07-01 00:00:00

  • Echocardiographic recognition of silent aortic root dilatation in Marfan's syndrome.

    abstract::Echocardiography has proven a useful and sensitive means to determine noninvasively the cardiac dimensions. This report describes the echocardiographic detection of progressive dilatation of the aortic root over an 18-month period, which led to death in a 33-year-old man with Marfan's syndrome; however, at no time was...


    pub_type: 杂志文章


    authors: Come PC,Bulkley BH,McKusick VA,Fortuin NJ

    更新日期:1977-12-01 00:00:00

  • Accuracy of an infrared tympanic thermometer.

    abstract:BACKGROUND:The use of infrared thermometry to measure temperatures in hospitalized patients is increasing. Although infrared thermometers have been proven to be accurate when they are used by well-trained personnel, no previous studies have examined their accuracy during routine hospital use. OBJECTIVE:To determine th...


    pub_type: 杂志文章


    authors: Amoateng-Adjepong Y,Del Mundo J,Manthous CA

    更新日期:1999-04-01 00:00:00