Flow-proportional administration of nitric oxide with a new delivery system: inspiratory nitric oxide concentration fluctuation during different flow conditions.

Abstract:

OBJECTIVE:To evaluate the accuracy of a flow-proportional delivery system and the pattern of inspiratory nitric oxide (NO) concentration during different flow conditions. DESIGN:Laboratory study in a lung model. SETTING:University experimental laboratory. SUBJECT:With a new delivery system, NO was administered proportional to the inspiratory flow into the inspiratory circuit to deliver a NO concentration of 10 and 30 ppm to a test lung during different ventilatory modes (volume-controlled ventilation [VCV], pressure-controlled ventilation [PCV], and airway pressure release ventilation [APRV]) with a fraction of inspired oxygen (FIO2) of 1.0. INTERVENTIONS:During VCV and PCV, the flow pattern was varied to achieve tidal volumes of 300, 600, and 900 mL, respectively, with inspiratory to expiratory time ratios of 1:3, 1:2, and 1:1. APRV was studied at a minute volume of 6, 12, and 18 L. Nitric oxides (NOx [NO+NO2]) and nitric dioxide (NO2) were monitored by chemiluminescence and electrochemical analysis. As the NO/N2 gas mixture is the only nitrogen source during ventilation with an FIO2 analyzer. RESULTS:During all flow conditions, NOx concentration was stable but slightly higher than expected. Measured and expected mean concentrations differed <9% (mean, <4%). Inspiratory NOx concentration fluctuation derived from N2 concentration was significantly higher than expected at higher flow rates, but this difference was not detected by chemiluminescence or electrochemical analysis. The NO2 production was not affected by the flow rate and was always < or =0.2 ppm (NO, 10 ppm) and < or =1.9 ppm (NO, 30 ppm). CONCLUSION:The tested NO delivery module administered stable mean inspiratory NO concentrations. Although inspiratory NO concentration fluctuates depending on the inspiratory flow rate, this delivery device allows stable NO administration without requiring adjustments when ventilator settings are changed.

journal_name

Chest

journal_title

Chest

authors

Sydow M,Bristow F,Zinserling J,Allen SJ

doi

10.1378/chest.112.2.496

subject

Has Abstract

pub_date

1997-08-01 00:00:00

pages

496-504

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)53023-7

journal_volume

112

pub_type

杂志文章

相关文献

CHEST文献大全
  • Terbutaline in the treatment of acute asthma in childhood.

    abstract::Forty-eight children with known asthma (ranging in age from 2 to 16 years) were studied during an acute attack. Each received either terbutaline or epinephrine subcutaneously in a random double-blind fashion. Measurement of heart rate, respiratory rate, and systemic arterial systolic and diastolic blood pressures and ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.72.5.614

    authors: Davis WJ,Pang LM,Chernack WJ,Mellins RB

    更新日期:1977-11-01 00:00:00

  • Symptomatic high grade heart block in Lyme disease.

    abstract::We describe an unusual and remediable form of heart block which developed in the course of Lyme disease. The diagnosis of Lyme disease requires a careful clinical history pertaining to epidemiologic geography or a history of erythema chronicum migrans. In this case, a highly selective cardiac abnormality responded pro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.2.236

    authors: Bedell SE,Pastor BM,Cohen SI

    更新日期:1981-02-01 00:00:00

  • Considerations in optimizing radiation therapy for non-small cell lung cancer.

    abstract::Irradiation therapy for lung cancer is mostly restricted to conventional methods. To improve therapeutic ratio, we have combined a treatment planning and a gene therapy approach. Three-dimensional conformal radiotherapy is described as carried out by methods of gene therapy for radiation protection using the manganese...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.1_supplement.46s

    authors: Greenberger JS,Bahri S,Jett J,Belani C,Kalend A,Epperly M

    更新日期:1998-01-01 00:00:00

  • Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

    abstract:STUDY OBJECTIVE:In these days, it was reported that bone marrow (BM) cells might take part in the remodeling of some systemic vascular diseases; however, it remains unknown whether the BM cells were involved in the vascular remodeling of pulmonary arteries and the progression of pulmonary hypertension (PH). The purpose...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.5.1793

    authors: Hayashida K,Fujita J,Miyake Y,Kawada H,Ando K,Ogawa S,Fukuda K

    更新日期:2005-05-01 00:00:00

  • The influence of high-frequency jet ventilation with varying cardiac-cycle specific synchronization on cardiac output in ARDS.

    abstract:BACKGROUND:Previous studies have shown "beat-to-beat" variation in systemic BP with high-frequency jet ventilation (HFJV). However, it is not clear if such changes are paralleled by changes in cardiac output. OBJECTIVE:To characterize the effect of HFJV near or equal to the heart rate (HR) on beat-to-beat cardiac outp...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.112.6.1600

    authors: Angus DC,Lidsky NM,Dotterweich LM,Pinsky MR

    更新日期:1997-12-01 00:00:00

  • Postinfluenza toxic shock syndrome.

    abstract::Postinfluenza toxic shock syndrome is a recently described entity that results from a respiratory tract infection with toxin-producing Staphylococcus aureus following an episode of influenza or influenzalike illness. This report describes a 19-year-old man who developed an influenza B respiratory infection complicated...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.95.5.1153

    authors: Prechter GC,Gerhard AK

    更新日期:1989-05-01 00:00:00

  • Work disability among adults with asthma.

    abstract:OBJECTIVE:To estimate the incidence of work disability among adults with asthma and to evaluate a clinically based illness severity score as a predictor of such disability. DESIGN:Baseline and follow-up telephone interviews and medical record review. SETTING:University-based outpatient pulmonary specialty practice. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.5.1371

    authors: Blanc PD,Jones M,Besson C,Katz P,Yelin E

    更新日期:1993-11-01 00:00:00

  • Thoracocentesis. Clinical value, complications, technical problems, and patient experience.

    abstract::A prospective study of 129 consecutive thoracocentesis in 86 patients at a university medical center evaluated the clinical value, complications, and patient experience with thoracocentesis. Pleural fluid analysis in conjunction with the clinical presentation placed 78 pleural fluids into diagnostic categories: defini...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.6.817

    authors: Collins TR,Sahn SA

    更新日期:1987-06-01 00:00:00

  • Purulent pericarditis with tamponade in a postpartum patient due to group F streptococcus.

    abstract::Bacterial pericarditis with cardiac tamponade is a life-threatening disorder that has been associated with a variety of organisms. There is usually an associated underlying condition or a seeding of the pericardium from an infection elsewhere. We report the development of cardiac tamponade and a subsequent pericardial...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.6.1746

    authors: Snyder RW,Braun TI

    更新日期:1999-06-01 00:00:00

  • Colloid osmotic pressure in infants with hyaline membrane disease.

    abstract::Colloid osmotic pressure (COP) was measured serially in 81 critically ill neonates with hyaline membrane disease (HMD) during the first five days of life, and these changes were correlated with the birth weight, gestational age, serum protein level, clinical status, and outcome. Colloid osmotic pressure correlated bet...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.5.776

    authors: Bhat R,Malalis L,Shukla A,Vidyasagar D

    更新日期:1983-05-01 00:00:00

  • Pain location, distribution, and intensity after cardiac surgery.

    abstract:STUDY OBJECTIVES:To study the location, distribution, and intensity of pain in a sample of adult cardiac surgery patients during their postoperative hospital stay. DESIGN:In a prospective study, pain location, distribution (number of pain areas per patient), and intensity (0 to 10 numerical rating scale) were document...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.391

    authors: Mueller XM,Tinguely F,Tevaearai HT,Revelly JP,Chioléro R,von Segesser LK

    更新日期:2000-08-01 00:00:00

  • Interposed abdominal compressions and carotid blood flow during cardiopulmonary resuscitation. Support for a thoracoabdominal unit.

    abstract::To determine if the timing of interposed abdominal compressions (IAC) affects the augmented blood flow during this form of cardiopulmonary resuscitation (CPR), we performed early-onset or late-onset abdominal compressions at three vascular volumes in nine dogs. Early-onset IAC began immediately following chest compres...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.6.1206

    authors: Einagle V,Bertrand F,Wise RA,Roussos C,Magder S

    更新日期:1988-06-01 00:00:00

  • Bronchial stenosis due to anthracofibrosis.

    abstract:STUDY OBJECTIVES:To define the clinical characteristics of the patients showing bronchoscopic findings of bronchial narrowing or obliteration with black pigmentation on overlying mucosa (we named this finding as "anthracofibrosis"), and to determine the association of anthracofibrosis with tuberculosis. PATIENTS AND M...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.113.2.344

    authors: Chung MP,Lee KS,Han J,Kim H,Rhee CH,Han YC,Kwon OJ

    更新日期:1998-02-01 00:00:00

  • Comparison of three different methods used to achieve local anesthesia for fiberoptic bronchoscopy.

    abstract::A patient's tolerance of fiberoptic bronchoscopy depends on the effectiveness of local anesthesia. This study compares the three different methods of local anesthesia in common use After sedation, patients (n = 53) received either 4 ml of 2.5 percent cocaine by intratracheal injection (TI) (n = 18), by bronchoscopic i...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.102.3.704

    authors: Graham DR,Hay JG,Clague J,Nisar M,Earis JE

    更新日期:1992-09-01 00:00:00

  • Advanced emphysema in African-American and white patients: do differences exist?

    abstract:BACKGROUND:Emphysema is the only smoking-related disease in which white patients have higher prevalence and higher attributable mortality rates than African-American patients. Epidemiologic studies have not addressed, nor explained, the observed racial differences in emphysema. STUDY OBJECTIVES:To determine whether wh...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.1.108

    authors: Chatila WM,Hoffman EA,Gaughan J,Robinswood GB,Criner GJ,National Emphysema Treatment Trial Research Group.

    更新日期:2006-07-01 00:00:00

  • ICU Admission Muscle and Fat Mass, Survival, and Disability at Discharge: A Prospective Cohort Study.

    abstract:BACKGROUND:Skeletal muscle dysfunction occurring as a result of ICU admission associates with higher mortality. Although preadmission higher BMI correlates with better outcomes, the impact of baseline muscle and fat mass has not been defined. We therefore investigated the association of skeletal muscle and fat mass at ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.10.023

    authors: Jaitovich A,Khan MMHS,Itty R,Chieng HC,Dumas CL,Nadendla P,Fantauzzi JP,Yucel RM,Feustel PJ,Judson MA

    更新日期:2019-02-01 00:00:00

  • Plasmacytoma as a cause of obstructive sleep apnea.

    abstract::Solitary extramedullary plasmacytomas are uncommon neoplasms. They occur most frequently in the upper aerodigestive tract and account for 4% of the nonepithelial tumors in this site. The evolution of a plasmacytoma is unsteady and symptoms at presentation have included dystonia, dysphagia, oral pain, cough, and dyspne...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.109.6.1657

    authors: Byrd RP Jr,Roy TM,Bentz W,Mehta JB

    更新日期:1996-06-01 00:00:00

  • Association Between BMI and Obesity With Survival in Pulmonary Arterial Hypertension.

    abstract:BACKGROUND:An obesity paradox, wherein patients who are obese have lower mortality, has been described in cardiopulmonary diseases, including pulmonary arterial hypertension (PAH). Our objective was to determine whether obesity and BMI are associated with mortality in patients with PAH. METHODS:We assessed incident pa...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.05.006

    authors: Weatherald J,Huertas A,Boucly A,Guignabert C,Taniguchi Y,Adir Y,Jevnikar M,Savale L,Jaïs X,Peng M,Simonneau G,Montani D,Humbert M,Sitbon O

    更新日期:2018-10-01 00:00:00

  • Safety of over-the-counter inhalers for asthma: report of the council on scientific affairs.

    abstract::The occasional use of over-the-counter (OTC) epinephrine inhalers appears to be safe and effective when used according to labeled instruction by individuals with mild, intermittent asthma. However, gross misuse of these products can cause severe adverse reactions, including death. Limited survey data suggest that appr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.522

    authors: Dickinson BD,Altman RD,Deitchman SD,Champion HC

    更新日期:2000-08-01 00:00:00

  • Daytime sleepiness and vascular morbidity at seven-year follow-up in obstructive sleep apnea patients.

    abstract::To evaluate the morbidity associated with obstructve sleep apnea syndrome (OSAS), we undertook a seven-year follow-up study of 198 OSAS patients seen between 1972 and 1980. The patients had been submitted to tracheostomy (71 patients) or had received a weight-loss recommendation (127 patients). Despite a lower mean ap...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.1.27

    authors: Partinen M,Guilleminault C

    更新日期:1990-01-01 00:00:00

  • Self-expanding stents in the treatment of tracheobronchial obstruction.

    abstract::The self-expandable stainless steel stents (Gianturco, William Cook, Bjaeverskov, Denmark) used extensively in biliary ducts and the vascular system have recently been modified for use in the tracheobronchial tree. Between March 1991 and September 1992, six patients with unresectable tracheobronchial and mediastinal d...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.1.86

    authors: Zannini P,Melloni G,Chiesa G,Carretta A

    更新日期:1994-07-01 00:00:00

  • Combination antihypertensive therapy among patients with COPD.

    abstract:BACKGROUND:COPD and hypertension both increase the risk of congestive heart failure (CHF). Current clinical trials do not inform the selection of combination antihypertensive therapy among patients with COPD. We performed a comparative effectiveness study to investigate whether choice of dual agent antihypertensive the...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-1770

    authors: Herrin MA,Feemster LC,Crothers K,Uman JE,Bryson CL,Au DH

    更新日期:2013-05-01 00:00:00

  • Continuous Fick cardiac output measurement during exercise by monitoring of mixed venous oxygen saturation and oxygen uptake.

    abstract::To determine whether continuous Fick cardiac output measurement is applicable to exercise testing, cardiac output data obtained by the continuous Fick method (Qcf) during exercise were compared with data obtained by the thermodilution method (Qth). Seventeen patients with old myocardial infarction underwent a 1-min or...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.2.419

    authors: Nakanishi N,Yoshioka T,Okano Y,Nishimura T

    更新日期:1993-08-01 00:00:00

  • Cost-effectiveness of fluticasone propionate administered via metered-dose inhaler plus babyhaler spacer in the treatment of asthma in preschool-aged children.

    abstract:STUDY OBJECTIVES:To evaluate the cost-effectiveness of inhaled fluticasone propionate (FP) in children aged 12 to 47 months with asthma symptoms. DESIGN:A retrospective economic analysis conducted from the perspective of the Danish health-care system, based on clinical data from a 12-week study. SETTING:Thirty-three ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.120.6.1835

    authors: Bisgaard H,Price MJ,Maden C,Olsen NA

    更新日期:2001-12-01 00:00:00

  • Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation.

    abstract:BACKGROUND:Contemporary clinical risk stratification schemata for predicting stroke and thromboembolism (TE) in patients with atrial fibrillation (AF) are largely derived from risk factors identified from trial cohorts. Thus, many potential risk factors have not been included. METHODS:We refined the 2006 Birmingham/Na...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.09-1584

    authors: Lip GY,Nieuwlaat R,Pisters R,Lane DA,Crijns HJ

    更新日期:2010-02-01 00:00:00

  • Improvement in pulmonary function in mitral stenosis after percutaneous transvenous mitral commissurotomy.

    abstract::Before and after percutaneous transvenous mitral commissurotomy (PTMC), pulmonary function studies were performed in 25 patients with mitral stenosis, in order to determine the effects of pulmonary hemodynamics on pulmonary function in patients with mitral stenosis. After PTMC, dramatic improvements in pulmonary hemod...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.2.290

    authors: Yoshioka T,Nakanishi N,Okubo S,Kunieda T,Ishikura F,Nagata S

    更新日期:1990-08-01 00:00:00

  • Indwelling pleural catheters reduce inpatient days over pleurodesis for malignant pleural effusion.

    abstract:BACKGROUND:Patients with malignant pleural effusion (MPE) have limited prognoses. They require long-lasting symptom relief with minimal hospitalization. Indwelling pleural catheters (IPCs) and talc pleurodesis are approved treatments for MPE. Establishing the implications of IPC and talc pleurodesis on subsequent hospi...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.11-2657

    authors: Fysh ETH,Waterer GW,Kendall PA,Bremner PR,Dina S,Geelhoed E,McCarney K,Morey S,Millward M,Musk AWB,Lee YCG

    更新日期:2012-08-01 00:00:00

  • Thrombocytopenia in the intensive care unit.

    abstract:STUDY OBJECTIVE:To determine the prevalence of thrombocytopenia in an ICU and assess which factors were associated with thrombocytopenia. DESIGN:A review of the medical records of patients admitted during 3 separate months during 1 academic year. Patients must have survived at least 12 h in the ICU. SETTING:A medical...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.4.1243

    authors: Baughman RP,Lower EE,Flessa HC,Tollerud DJ

    更新日期:1993-10-01 00:00:00

  • Usefulness of fine-needle aspiration biopsy of spleen in diagnosis of sarcoidosis.

    abstract::Fine-needle aspiration biopsy of the spleen was carried out in 557 patients. In 381 cases, the aspiration was performed because of suspected sarcoidosis. The sensitivity of the technique was 59 percent and the specificity 97 percent. The cytologic picture of the spleen was abnormal in 184 patients with sarcoidosis and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.2.193

    authors: Selroos O,Koivunen E

    更新日期:1983-02-01 00:00:00

  • Limitations of the fast green assay for chemosensitivity testing in human lung cancer.

    abstract::Selection of patients with lung cancer who are most likely to benefit from chemotherapeutic treatment would be a substantial step forward. Therefore, a prospective study in predictive chemosensitivity testing in vitro using the fast green assay (FGA) as developed by Weisenthal et al was carried out. Sixty-six pretreat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.5.1358

    authors: Smit EF,de Vries EG,Meijer C,Mulder NH,Postmus PE

    更新日期:1991-11-01 00:00:00