Abstract:
UNLABELLED:STUDY OBJECTIVES AND DESIGN: Health-related quality of life (QoL) instruments are generally used for studies of asthma in specialized settings. For primary care use, there is a need for brief and simple questionnaires for structured patient-reported outcomes. We validated the Mini-Asthma Quality of Life Questionnaire (Mini-AQLQ), using the Asthma Quality of Life Questionnaire with standardized activities (AQLQ[S]) as the "gold standard." The Asthma Control Questionnaire (ACQ) was validated against the symptoms domain of the AQLQ(S). Patients were characterized by the Short Form-36 Health Survey (SF-36). SUBJECTS:One hundred eight patients (68 women) with asthma diagnosed by their physicians from 24 primary care centers completed two visits (2 to 3 months apart). Their mean SF-36 scores were lower than the national norm for all domains. RESULTS:The Mini-AQLQ and ACQ correlated well with the AQLQ(S). Reliability, determined in 57 patients with stable AQLQ(S) scores, was good. Both brief questionnaires detected improvement or deterioration of patients at the group level. Global ratings of disease severity by patients or clinicians correlated poorly with disease-specific QoL scores. CONCLUSIONS:The Mini-AQLQ and ACQ instruments are sufficiently simple and robust to be suitable for research and quality of care monitoring in primary care at the group level. They may, after further validation, even be useful in the management of individual patients.
journal_name
Chestjournal_title
Chestauthors
Ehrs PO,Nokela M,Ställberg B,Hjemdahl P,Wikström Jonsson Edoi
10.1378/chest.129.4.925subject
Has Abstractpub_date
2006-04-01 00:00:00pages
925-32issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)38807-3journal_volume
129pub_type
杂志文章,多中心研究相关文献
CHEST文献大全abstract::Human lung mast cells have been reported recently to contain small amounts of the elastolytic protease present in the neutrophil and implicated in the pathogenesis of alveolar wall destruction in emphysema. Since mast cells are numerous within alveolar walls, release of inflammatory mediators (and possibly elastase) b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.1.119
更新日期:1988-07-01 00:00:00
abstract:STUDY OBJECTIVE:Immune and inflammatory mechanisms could play a significant role in pulmonary arterial hypertension (PAH) genesis or progression, especially in patients with connective tissue diseases. Immunosuppressive therapy should be better evaluated in this setting. STUDY DESIGN:Monocentric retrospective study. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.1.182
更新日期:2006-07-01 00:00:00
abstract:STUDY OBJECTIVES:Nasal polyps frequently appear in patients with cystic fibrosis (CF). The aims of this study were to focus on what problems (symptoms, endoscopic findings, and laboratory correlates) nasal polyps cause the CF patient, and how these correlate to the total health situation of this patient group. PATIENT...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.1.40
更新日期:2002-01-01 00:00:00
abstract::Alterations in peripheral vascular tone are presumed to contribute to circulatory failure during severe sepsis. Decreased venous tone with venous pooling may decrease effective circulatory blood volume, while decreased arterial tone with redistribution of systemic blood may compromise tissue nutrient flow. We compared...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.363
更新日期:1989-08-01 00:00:00
abstract::The objective of this study was to determine the following: (1) if standard clinical evaluation is sufficient to provide an accurate estimate of hemodynamic status of unstable ICU patients; (2) the impact of pulmonary artery catheterization (PAC) on diagnosis and treatment plan; and (3) whether therapy provided after ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.6.1451
更新日期:1991-06-01 00:00:00
abstract::Three patients under two years of age are described with unusual fistulas involving the brachiocephalic arteries and the innominate vein or the superior vena cava. Two patients were asymptomatic, and one newborn was cyanotic and in congestive failure. This unusual presentation has only rarely been reported in thoracic...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.92.5.897
更新日期:1987-11-01 00:00:00
abstract::Cocaine use is associated with adverse events in nearly every organ system. Cardiovascular complications include hemorrhagic and ischemic stroke, aortic dissection, cardiomyopathy, accelerated coronary artery disease, myocardial infarction, and sudden cardiac death. Syncope may be the presenting symptom in these condi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.1.275
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:It is unknown if the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. METHODS:We reviewed records from 177 patients with HP...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2623
更新日期:2013-08-01 00:00:00
abstract::Selection of patients with lung cancer who are most likely to benefit from chemotherapeutic treatment would be a substantial step forward. Therefore, a prospective study in predictive chemosensitivity testing in vitro using the fast green assay (FGA) as developed by Weisenthal et al was carried out. Sixty-six pretreat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.5.1358
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Although the physiologic range of pulmonary artery systolic pressure (PASP) has been reported, data on how it is manifested in athletes are limited. The aim of the present study was to explore the full spectrum of PASP and the long-term training impact in a large population of highly trained athletes. METHO...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.10-1260
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:In daily clinical work, we often face delayed or recurrent pneumothorax after radiofrequency (RF) ablation for lung tumors, but a large study on this theme has not been done. Thus, we examined the rate of delayed or recurrent pneumothorax after RF ablation for lung tumors and the risk factors associated with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-1499
更新日期:2009-04-01 00:00:00
abstract::We describe 12 patients with simultaneous bilateral spontaneous pneumothorax (SBSP). They represent 4 percent of patients with spontaneous pneumothorax seen at our hospital from 1971 to 1990. Five of the 12 had no underlying lung disease. In the seven remaining patients, SBSP was secondary to histiocytosis X, lymphang...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.4.1142
更新日期:1994-04-01 00:00:00
abstract:STUDY OBJECTIVES:To describe the prevalence of parental prompting to smoke (eg, parent requests that their child light the parent's cigarette in his/her own mouth) in a sample of families, and to assess the agreement between child and parent reports of the prompting behaviors. DESIGN, SETTING, AND PARTICIPANTS:A total...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.125.2.429
更新日期:2004-02-01 00:00:00
abstract::As the actual mortality and morbidity of obstructive sleep apnea syndrome (OSAS) have been unknown heretofore, we undertook a follow-up study of 198 OSAS patients seen at the Stanford Sleep Disorders Clinic between 1972 and 1980, for whom either tracheostomy (71 patients) or weight loss (127 patients) had been recomme...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.6.1200
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Lowest receptor occupancy for a drug occurs at trough prior to the next dose. Previous studies have focused on the effects of triple therapy at peak dose intervals using forced expiratory maneuvers. Impulse oscillometry (IOS) and body plethysmography (PLETH) are more sensitive than spirometry to assess inhal...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.10-0247
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Infused and inhaled treprostinil are effective for treatment of pulmonary arterial hypertension (PAH), although their administration routes have limitations. This study assessed the efficacy and safety of bid oral sustained-release treprostinil in the treatment of PAH with a concomitant endothelin receptor a...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.11-2212
更新日期:2012-12-01 00:00:00
abstract::Recurrent pericardial effusion or tamponade can complicate malignant disease. The medical approach with pharmacologic agents has a high recurrence rate. Balloon pericardiotomy (BP) may provide a less invasive alternative to surgery. We performed BP in ten high-risk patients with malignant pericardial tamponade (MPT). ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1499
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The antisynthetase syndrome consists of interstitial lung disease (ILD), arthritis, myositis, fever, mechanic's hands, and Raynaud phenomenon in the presence of an antisynthetase autoantibody, most commonly anti-Jo-1. It is believed that all the antisynthetases are associated with a similar clinical profile,...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-2233
更新日期:2009-06-01 00:00:00
abstract::Sleep health is a multidimensional construct that includes adequate duration, quality, and appropriately timed sleep that may be influenced by environmental factors. In this review, we focus on how an individual's living and sleeping environment, both the surrounding neighborhood physical and social features and the a...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2019.12.002
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Unlike studies on leg exercise, reports on the regulation of dynamic hyperinflation during arm exercise are scanty. We ascertained the following in patients with COPD: (1) whether and to what extent upper-limb exercise results in dynamic hyperinflation, and (2) the mechanism whereby an arm-training program (...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1225
更新日期:2005-09-01 00:00:00
abstract::A radioaerosol procedure using 99mcTc-DTPA (diethylene triamine penta acetate) was used to evaluate the permeability of the pulmonary epithelium in smokers and nonsmokers. The average clearance of this indicator from the lungs of smokers without significant airway obstruction exceeded that found in normal subjects by ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.1.6
更新日期:1983-01-01 00:00:00
abstract::A series of 24 adult male patients undergoing thoracotomy were found to have a reduction in their cough pressures in the immediate postoperative period to 29 percent of their preoperative values. Cough pressures still averaged only 50 percent of control values one week following surgery, with slow return toward normal...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.6.654
更新日期:1975-06-01 00:00:00
abstract::Recent studies have suggested that vasodilators may acutely improve pulmonary hemodynamics in patients with chronic obstructive pulmonary disease and cor pulmonale, but the effects of long-term therapy have not been assessed. We evaluated the hemodynamic and gas exchange effects of nitrendipine, a calcium channel bloc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.1.141
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Patients with malignant pleural effusion (MPE) have limited prognoses. They require long-lasting symptom relief with minimal hospitalization. Indwelling pleural catheters (IPCs) and talc pleurodesis are approved treatments for MPE. Establishing the implications of IPC and talc pleurodesis on subsequent hospi...
journal_title:Chest
pub_type: 杂志文章,多中心研究
doi:10.1378/chest.11-2657
更新日期:2012-08-01 00:00:00
abstract:INTRODUCTION:The current invasive and noninvasive methods for delivering long-term ventilatory support rely on cumbersome patient interfaces that may interfere with upper airway function. To overcome these limitations, a novel system was developed to ventilate conscious, spontaneously breathing dogs through a self-cont...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.122.5.1742
更新日期:2002-11-01 00:00:00
abstract:STUDY OBJECTIVE:To examine the relation of smoking habits and development of asthma in a large cohort of US women. DESIGN:Prospective cohort study. PARTICIPANTS:Among 74,072 women, 34 to 68 years of age, who were free of major diseases, we documented 671 incident asthma cases and 798 incident cases of chronic bronchi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1557
更新日期:1995-12-01 00:00:00
abstract::A 60-year-old man presented with features of superior vena cava (SVC) obstruction. On evaluation, he was diagnosed as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). SVC obstruction due to AILD, to our knowledge, has not been described. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.6.1721
更新日期:1991-12-01 00:00:00
abstract::We present the first case (to our knowledge) of acetaminophen-induced eosinophilic pneumonia. Although the patient had taken an acetaminophen-containing combination drug, Kinuya-chinnetsu, for only three days, the abnormal shadow on his chest radiograph continued for about a month. Lymphocyte stimulation tests showed ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.1.291
更新日期:1993-07-01 00:00:00
abstract::The purpose of this study was to determine the number of procedures necessary to become proficient in flexible fiberoptic bronchoscopic examination. I performed 99 bronchoscopic procedures during a formal training program under the direct supervision of instructors with varying experience. There were no statistical di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.1.65
更新日期:1980-01-01 00:00:00
abstract::Tests of overall lung function often reveal abnormalities in elderly smokers, but lung function is less consistently deranged in young smokers. Since airway closure at higher than normal lung volumes is thought to be an early indicator of lung dysfunction in asymptomatic smokers, we used 133xenon to measure regional r...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.79.1.12
更新日期:1981-01-01 00:00:00