Skeletal muscle blood flow and venous capacitance in patients with severe sepsis and systemic hypoperfusion.

Abstract:

:Alterations in peripheral vascular tone are presumed to contribute to circulatory failure during severe sepsis. Decreased venous tone with venous pooling may decrease effective circulatory blood volume, while decreased arterial tone with redistribution of systemic blood may compromise tissue nutrient flow. We compared forearm arterial and venous tone and forearm blood flow in ten patients with and ten patients without sepsis. The FVT, MVC, and FBF were measured by air plethysmography. In the septic patients, MCV was 1.4 +/- 0.1 ml compared with 3.1 +/- 0.2 ml in nonseptic patients (p less than 0.01). The FVT was 13.4 +/- 1.0 mm Hg/ml in septic patients versus 7.0 +/- 0.5 mm Hg/ml in nonseptic patients (p less than 0.01). The ratio of FBF to cardiac output was 0.28 +/- 0.07 percent in septic patients and 0.31 +/- 0.07 percent in nonseptic patients. These data suggest that increased peripheral venous capacitance and redistribution of skeletal muscle blood flow are not present in patients with sepsis.

journal_name

Chest

journal_title

Chest

authors

Astiz ME,Rackow EC,Haydon P,Karras G,Weil MH

doi

10.1378/chest.96.2.363

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

363-6

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)45931-8

journal_volume

96

pub_type

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