Abstract:
BACKGROUND:The purpose of this study was to determine how common sleep-related desaturation with preserved awake resting pulse oximetric saturation (SpO(2)) was in a large cohort of adult cystic fibrosis (CF) patients with variable degrees of pulmonary disease. We then determined whether nocturnal desaturation could reliably be predicted from standard clinical and exercise parameters. METHODS:Seventy CF patients participated in the study (mean [SD] age, 27.3 [8.7] years; women, 54%; percent predicted FEV(1) [%predFEV(1)], 55.7% [23.9%]). Nocturnal, resting, and exercise SpO(2) were measured. Nocturnal oximetry was measured in the patient's home. Maximal oxygen capacity (Vo(2)max) was determined from a graded exercise test on a stationary bicycle ergometer. The Shwachman-Kulczycki (S-K) illness severity score was calculated incorporating categories of functional capacity, physical examination, nutrition, and chest radiograph. RESULTS:Multivariate analysis reported significant differences (p < 0.0001) between pulmonary disease severity and overall distribution of nocturnal SpO(2), with the main difference being for patients with severe pulmonary disease (%predFEV(1) of < 50%) compared to patients with mild or moderate disease in the SpO(2) intervals of 100 to 96% (p < 0.0001) and 90 to 86% (p = 0.0001). Pulmonary function, S-K clinical scores, f1.gif" BORDER="0">O(2)max, and resting and maximal SpO(2) correlated significantly (p < 0.05) with nocturnal SpO(2) levels. Stepwise discriminant analysis identified %predFEV(1) (or S-K scores) and resting SpO(2) as the parameters that could best discriminate patients not likely to experience nocturnal desaturation. Specifically, our equation could predict 91% of cases less likely to nocturnally desaturate, but could only modestly predict those more likely to desaturate (i.e., 26% of cases). CONCLUSIONS:Spirometric parameters and measurements of awake resting oxygenation are of limited utility in predicting nocturnal desaturation. Nocturnal oximetry should be considered in patients with moderate to severe lung disease even with preserved awake resting SpO(2).
journal_name
Chestjournal_title
Chestauthors
Frangolias DD,Wilcox PGdoi
10.1378/chest.119.2.434subject
Has Abstractpub_date
2001-02-01 00:00:00pages
434-41issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)38219-2journal_volume
119pub_type
杂志文章相关文献
CHEST文献大全abstract::A retrospective study of 34 patients (33 male and one female) was conducted to evaluate a potential correlation between patient survival, propensity to metastasize and specific subtypes of pulmonary adenocarcinomas as determined by ultrastructural examination. Previous electron microscopic studies of pulmonary adenoca...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.5.581
更新日期:1983-11-01 00:00:00
abstract::Nocturnal noninvasive ventilation (NNV), the provision of ventilatory assistance via a noninvasive interface mainly during sleep, has assumed an important role in the management of chronic hypoventilatory syndromes. This review focuses on recent developments related to the use of NNV to treat various forms of chronic ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.07-1527
更新日期:2008-05-01 00:00:00
abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.6.1794
更新日期:1992-12-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the usefulness of routinely inserting a hollow airway exchange catheter (jet stylet) prior to tracheal extubation of adult patients with risk factors for difficult tracheal intubation. DESIGN:Prospective, 1-year study of 40 consecutive patients undergoing mechanical ventilation who had one...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.6.1660
更新日期:1997-06-01 00:00:00
abstract::Fatal pulmonary embolism (PE) is a major cause of mortality in patients with spinal cord injury. In order to ascertain those characteristics that might predict this event, we reviewed the records of all patients with autopsy-proven massive PE admitted to a regional spinal cord care center over a 5-year period. The inf...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.3.853
更新日期:1994-03-01 00:00:00
abstract:STUDY OBJECTIVES:To study the location, distribution, and intensity of pain in a sample of adult cardiac surgery patients during their postoperative hospital stay. DESIGN:In a prospective study, pain location, distribution (number of pain areas per patient), and intensity (0 to 10 numerical rating scale) were document...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.2.391
更新日期:2000-08-01 00:00:00
abstract::Care of ventilator-dependent patients requires considerable resources, yet the long-term outcomes of this type of care have rarely been described. We retrospectively investigated the posthospital course of elderly patients who survived an episode of prolonged ventilator dependency to describe survival rates, subsequen...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.5.1120
更新日期:1989-11-01 00:00:00
abstract:STUDY OBJECTIVES:Levofloxacin is a fluoroquinolone antimicrobial agent for which pharmacodynamic relationships between the maximum serum antibiotic concentration (Cmax)/minimum inhibitory concentration (MIC) ratio and/or the area under the serum concentration-time curve during a 24-h dosing period (AUC(0-24))/MIC ratio...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.128.4.2093
更新日期:2005-10-01 00:00:00
abstract::Cumulative dose response curves to inhaled methacholine were established in 24 "healthy" children of asthmatic parents and 7 healthy children of healthy parents. Atopic children of asthmatic parents demonstrated higher bronchial hyperreactivity (BHR) than nonatopic children. The BHR was about ten times less than in th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.97.2.285
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Over the last 25 years, a growing number of clinical trials have evaluated novel sepsis therapies. To promote uniformity in inclusion criteria for patient enrollment, the American College of Chest Physicians and Society of Critical Care Medicine first published consensus conference definitions for sepsis in ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.1.242
更新日期:2005-01-01 00:00:00
abstract::The effects of erythromycin on the NADPH oxidase activity in the neutrophils of normal subjects and patients with bronchiolitis were investigated. In the patients receiving erythromycin, NADPH oxidase activity was significantly lower in a whole-cell system than that before therapy. Erythromycin was also found to inhib...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.4.1191
更新日期:1993-10-01 00:00:00
abstract::Natural killer-cell activity of fresh interstitial pulmonary cell populations from patients with squamous cell and adenocarcinoma of the lung and carcinoma metastatic to the lung was assessed and compared to that of apparently normal lung. No increase in the percentage of lymphoid cell populations was noted in the int...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.1.26
更新日期:1987-01-01 00:00:00
abstract::We present the first case (to our knowledge) of acetaminophen-induced eosinophilic pneumonia. Although the patient had taken an acetaminophen-containing combination drug, Kinuya-chinnetsu, for only three days, the abnormal shadow on his chest radiograph continued for about a month. Lymphocyte stimulation tests showed ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.104.1.291
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:No studies have attempted to examine the genetic influence on the habit of snoring. The aim of the present study was to examine whether an association existed between self-reported snoring and family history of snoring and a number of genetic markers. MATERIAL AND METHODS:The data were derived from a primar...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.5.1289
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:This study was designed to determine the incidence rate, define risk factors, and suggest proper management protocols for pulmonary artery (PA) rupture associated with Swan-Ganz catheters. DESIGN:This is a retrospective chart-review study. SETTING:This study involved 32,442 inpatients requiring hemodynamic...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.5.1349
更新日期:1995-11-01 00:00:00
abstract::Atrioventricular nodal alternating Wenckebach periods were defined as episodes of 2:1 atrioventricular block in which there was a gradual increase in transmission intervals of conducted beats ending in two or three consecutively blocked atrial impulses. This is one of the mechanisms whereby 2:1 atrioventricular block ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.73.1.69
更新日期:1978-01-01 00:00:00
abstract::Alterations in peripheral vascular tone are presumed to contribute to circulatory failure during severe sepsis. Decreased venous tone with venous pooling may decrease effective circulatory blood volume, while decreased arterial tone with redistribution of systemic blood may compromise tissue nutrient flow. We compared...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.363
更新日期:1989-08-01 00:00:00
abstract::Indirect evidence from airway pressure recordings in mechanically ventilated patients suggests that the diaphragm exhibits contractile activity beyond that required to trigger a ventilator-assisted breath. We used the diaphragmatic EMG to provide direct evidence of persistent contractile activity and studied the effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.1.130
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with CO...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.01.043
更新日期:2020-07-01 00:00:00
abstract:PURPOSES:Patients receiving prolonged acute mechanical ventilation (PAMV), although comprising a third of all mechanical ventilation (MV) patients, consume two-thirds of all the resources allocated to MV, and their numbers are projected to double by 2020. By virtue of their prolonged hospital length of stay (median LOS...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-0596
更新日期:2009-09-01 00:00:00
abstract::In order to assess the complications of sleep apnea, we have reviewed a data base of 619 consecutive admissions to a university sleep disorders center. Although patients with obstructive sleep apnea (OSA) described more subjective sleepiness than patients with central sleep apnea (CSA) or primary snoring (PS), the mul...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.903
更新日期:1992-04-01 00:00:00
abstract::A case of acute and recrudescent melioidosis complicated by pericarditis and pericardial effusion is described. The potential for the appearance of future cases in the United States and the necessity for physicians to remain aware of this potential diagnosis are discussed. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.2.227
更新日期:1976-02-01 00:00:00
abstract:STUDY OBJECTIVES:It has been suggested that sleep-disordered breathing (SDB) is a risk factor for ischemic heart disease, and may be associated with increased morbidity and mortality due to cardiovascular disease. The aim of this study was to examine the relation between nocturnal oxygen desaturation (NOD) due to SDB a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.124.3.936
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general populati...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.11-1474
更新日期:2012-08-01 00:00:00
abstract::Preclinical studies indicate that allogeneic human mesenchymal stem cells (MSC) may be useful for the treatment of several clinical disorders, including sepsis, acute renal failure, acute myocardial infarction, and more recently, acute lung injury (ALI). This article provides a brief review of the biologic qualities o...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.10-0518
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The study aimed to evaluate the effect of upper extremity resistance training for patients with COPD on dyspnea during activity of daily living (ADL), arm function, arm exercise capacity, muscle strength, and health-related quality of life (HRQL). METHODS:Patients were randomly assigned to an intervention o...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.10-1292
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and significance of pericardial abnormalities in systemic sclerosis (SSc)-related interstitial lung disease (ILD). METHODS:Retrospective study of 41 subjects with SSc-related ILD who underwent evaluation including thoracic high-resolution CT (HRCT) imaging, transthoracic echocard...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-2317
更新日期:2007-04-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.118.3.691
更新日期:2000-09-01 00:00:00
abstract::Postoperative bronchial stump failure is a life-threatening complication, and several surgical approaches and procedures have been developed to close the stump. In this report, we describe a case of left mainstem bronchial stump diastasis after pneumonectomy for lung cancer, in which the bronchial stump was re-closed ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.3.884
更新日期:2000-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the incidence and clinical factors related to the persistence of infarct-associated pericardial effusion (PE) after primary angioplasty. DESIGN:Consecutive case-series analysis. SETTING:Coronary care unit in a university hospital. PATIENTS:Three hundred ninety-one consecutive patients wit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.2.798
更新日期:2005-08-01 00:00:00