Abstract:
:Cumulative dose response curves to inhaled methacholine were established in 24 "healthy" children of asthmatic parents and 7 healthy children of healthy parents. Atopic children of asthmatic parents demonstrated higher bronchial hyperreactivity (BHR) than nonatopic children. The BHR was about ten times less than in the atopic parents of asthmatic children, indicating marked increase in BHR with age in atopic members of asthmatic families. Six weeks of treatment with cromolyn sodium (disodium cromoglycate) decreased BHR significantly (p less than 0.05) in eight atopic children, while no change occurred in BHR in five nonatopic children.
journal_name
Chestjournal_title
Chestauthors
Bruderman I,Cohen R,Schachter Jdoi
10.1378/chest.97.2.285subject
Has Abstractpub_date
1990-02-01 00:00:00pages
285-7issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)40657-9journal_volume
97pub_type
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