Bronchial response to methacholine in "healthy" children of asthmatic parents. Effect of treatment with cromolyn sodium.

Abstract:

:Cumulative dose response curves to inhaled methacholine were established in 24 "healthy" children of asthmatic parents and 7 healthy children of healthy parents. Atopic children of asthmatic parents demonstrated higher bronchial hyperreactivity (BHR) than nonatopic children. The BHR was about ten times less than in the atopic parents of asthmatic children, indicating marked increase in BHR with age in atopic members of asthmatic families. Six weeks of treatment with cromolyn sodium (disodium cromoglycate) decreased BHR significantly (p less than 0.05) in eight atopic children, while no change occurred in BHR in five nonatopic children.

journal_name

Chest

journal_title

Chest

authors

Bruderman I,Cohen R,Schachter J

doi

10.1378/chest.97.2.285

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

285-7

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40657-9

journal_volume

97

pub_type

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