Abstract:
:A study to assess the effect of the long-term use of triamcinolone acetonide (TA) on adrenal function was conducted with 143 male and female patients with asthma who were randomly assigned to receive 800, 1200, or 1,600 micrograms of TA daily for six months. Adrenal function was assessed prior to treatment and after two weeks and one, three, and six months of TA use. The effect of TA was evaluated by measuring plasma cortisol levels just prior to and 30 min after a bolus IV injection of 0.25 mg cosyntropin. Adrenal suppression was assumed if the plasma concentration of cortisol did not increase by at least 7 micrograms/dl from the prestimulation value, and remained below 18 micrograms/dl 30 min after the cosyntropin injection. Urine collected for 24 h prior to each cosyntropin stimulation was assayed for free cortisol and related metabolites to confirm suppression. Although all treatment regimens caused some reduction in the 24-h excretion of corticosteroid products, none of the mean values was below the normal ranges. The mean data indicate that TA had no significant effect on adrenal function at any dose or at any time for the patients overall. Individually, three patients exhibited some reduction in adrenal function.
journal_name
Chestjournal_title
Chestauthors
Altman LC,Findlay SR,Lopez M,Lukacsko P,Morris RJ,Pinnas JL,Ratner PH,Szefler SJ,Welch MJdoi
10.1378/chest.101.5.1250subject
Has Abstractpub_date
1992-05-01 00:00:00pages
1250-6issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(16)34124-1journal_volume
101pub_type
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