Factitious methemoglobinemia caused by hyperlipemia.

Abstract:

:Hyperlipemia in an acyanotic patient with diabetic ketoacidosis, alcoholism, and pancreatitis produced a falsely elevated concentration of methemoglobin (19 percent) and a lower-than-expected oxygen saturation measured with an automated spectrophotometer (IL-282 CO-Oximeter). In addition, there was a "normal" hemoglobin level despite a low hematocrit reading. In vitro studies showed that hyperlipemia corresponding to triglyceride levels of 500 mg/100 ml and greater produced erroneously high values for methemoglobin and total hemoglobin and "negative" values for carboxyhemoglobin. These abnormalities disappeared when the excessive lipids were removed by washing the erythrocytes in physiologic saline solution.

journal_name

Chest

journal_title

Chest

authors

Spurzem JR,Bonekat HW,Shigeoka JW

doi

10.1378/chest.86.1.84

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

84-6

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40333-2

journal_volume

86

pub_type

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