Abstract:
:Although nearly 3,000 e-cigarette-related hospitalizations have been reported in North America, the long-term outcomes in these patients have not been described. We followed an 18-year-old boy who survived acute critical illness and respiratory failure related to 5 months of e-cigarette use. Chronic irreversible airflow obstruction and markedly abnormal 129Xe MRI ventilation heterogeneity was observed and persisted 8 months after hospital discharge, despite improvement in quality-of-life and chest CT findings. Lung clearance index and oscillometry measures were also highly abnormal at 8 months postdischarge. Although 129Xe MRI ventilation abnormalities were dominant in the lung apices and central lung regions, the pattern of ventilation defects was dissimilar to ventilation heterogeneity observed in patients with obstructive lung disease, such as asthma and COPD. Our findings underscore the long-term functional impacts of e-cigarette-related lung injury in survivors of critical illness; longitudinal evaluations may shed light on the pathophysiologic mechanisms that drive e-cigarette-related lung disease.
journal_name
Chestjournal_title
Chestauthors
Eddy RL,Serajeddini H,Knipping D,Landman ST,Bosma KJ,Mackenzie CA,Dhaliwal I,Parraga Gdoi
10.1016/j.chest.2020.06.005subject
Has Abstractpub_date
2020-10-01 00:00:00pages
e147-e151issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(20)31669-Xjournal_volume
158pub_type
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