Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control.

Abstract:

BACKGROUND:Combination therapy with inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs), or treatment with high doses of ICSs alone improves asthma control when therapy with low-dose ICSs is not sufficient. However, it is not known which of these treatment options is more effective in sustaining asthma control. OBJECTIVES:To evaluate the effect of increasing the ICS dosage vs adding LABAs on the time spent with well-controlled asthma or poorly controlled asthma. METHODS:Post hoc analysis of the Formoterol and Corticosteroid Establishing Therapy study, which compared a fourfold increase in the budesonide dose with and without formoterol. RESULTS:Time with well-controlled asthma was improved by 19% (95% confidence interval [CI], 3 to 35%; p = 0.017) by adding formoterol, 24 microg/d, to therapy with budesonide, 200 microg/d, compared to 2% (95% CI, -9 to 12%; p = 0.76) with therapy with budesonide, 800 microg/d, alone. Time with well-controlled asthma was further improved by 29% (95% CI, 13 to 47%; p < 0.001) by adding formoterol to therapy with budesonide, 800 microg/d. Time with poorly controlled asthma was significantly reduced using the same interventions by 43% (95% CI, 25 to 57%), 22% (95% CI, 7 to 44%), and 50% (95% CI, 30 to 64%), respectively. Adding formoterol to budesonide was significantly more effective in increasing time with well-controlled asthma when compared to increasing the budesonide dose fourfold (increase, 16%; 95% CI, 1 to 33%; p = 0.035), with a trend for a greater reduction in time with poor control (decrease, 21%; 95% CI, -5 to 42%). CONCLUSION:The addition of formoterol to therapy with low-dose budesonide increases the probability of well-controlled asthma compared to a substantial increase in the dose of an ICS.

journal_name

Chest

journal_title

Chest

authors

O'Byrne PM,Naya IP,Kallen A,Postma DS,Barnes PJ

doi

10.1378/chest.08-1018

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1192-1199

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(09)60018-0

journal_volume

134

pub_type

杂志文章,随机对照试验

相关文献

CHEST文献大全
  • Respiratory failure due to pulmonary lymphangitis carcinomatosis.

    abstract::A man with primary lung cancer developed respiratory failure due to lymphangitis carcinomatosis that was diagnosed by transbronchial lung biopsy specimen. After combination chemotherapy with high-dose etoposide and cisplatin (CDDP), he was able to cease oxygen therapy and showed improvement of his lymphangitis carcino...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.3.967

    authors: Fujita J,Yamagishi Y,Kubo A,Takigawa K,Yamaji Y,Takahara J

    更新日期:1993-03-01 00:00:00

  • A 2-Year-Old Boy With Hypoxemia, Pulmonary Hypertension, and Digital Clubbing.

    abstract:CASE PRESENTATION:A 2-year-old boy was referred to the Ankara University School of Medicine Children's Hospital with a history of recurrent respiratory distress and cyanosis since birth. His medical history was significant for premature birth at 31 weeks via cesarean section, as an infant of a diabetic mother. There wa...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2020.08.2103

    authors: Zirek F,Akova BŞ,Özcan G,Fitoz S,Çobanoğlu N

    更新日期:2021-01-01 00:00:00

  • Prospective randomized trial of talc slurry vs bleomycin in pleurodesis for symptomatic malignant pleural effusions.

    abstract:OBJECTIVE:Symptomatic malignant pleural effusions are common sequelae in patients with certain malignancies. Pleurodesis via bedside thoracostomy is the current treatment option most commonly used. To our knowledge, this is the first prospective randomized trial to examine which agent, bleomycin or talc slurry, is supe...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.112.2.430

    authors: Zimmer PW,Hill M,Casey K,Harvey E,Low DE

    更新日期:1997-08-01 00:00:00

  • The lung in immunoblastic lymphadenopathy.

    abstract::Immunoblastic lymphadenopathy presents with fever, malaise, cough, dyspnea, lymphadenopathy, hepatosplenomegaly, hypergammaglobulinemia, interstitial pulmonary infiltrates, mediastinal adenopathy, and effusions. The diagnosis is made on the basis of lymph node biopsy. Based on the course in our patients and the cases ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.3.312

    authors: Bradley SL,Dines DE,Banks PM,Hill RW

    更新日期:1981-09-01 00:00:00

  • Increased proportions of peripheral blood gamma delta T cells in patients with pulmonary tuberculosis.

    abstract::There is a small population of peripheral T cells bearing the gamma delta T-cell receptor, which may be involved in the defense against invading microorganisms and tumor cells. The present study was designed to evaluate the levels of gamma delta T cells in patients with pulmonary tuberculosis, bacterial pneumonia, chr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.1.195

    authors: Ito M,Kojiro N,Ikeda T,Ito T,Funada J,Kokubu T

    更新日期:1992-07-01 00:00:00

  • Peripheral arterial embolism due to a left ventricular diverticulum in a young adult.

    abstract::A 32-year-old man was admitted to the emergency department of our hospital after experiencing a peripheral arterial embolism. Investigation of the possible embolic sources in an otherwise asymptomatic patient revealed the existence of a left ventricular diverticulum. The left ventricular diverticulum is a rare congeni...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.127.4.1452

    authors: Parthenakis FI,Kochiadakis GE,Patrianakos AP,Hamilos MI,Mitrouska I,Katsamouris AN,Vardas PE

    更新日期:2005-04-01 00:00:00

  • Small cell lung cancer. Case report.

    abstract::The selection of appropriate chemotherapeutic and/or radiation therapy for small cell lung cancer should be done after careful diagnosis and staging workup. A patient with small cell lung cancer is presented and explanation given for each step in diagnosis and staging. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.6_supplement.241s

    authors: O'Donnell WJ

    更新日期:1995-06-01 00:00:00

  • The prevalence of exercise-induced bronchospasm among US Army recruits and its effects on physical performance.

    abstract:STUDY OBJECTIVES:To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults. DESIGN:Observational, retrospective study. SETTING:Fort Jackson, SC, May to July 1998. PARTICIPANTS:One hundred thirty-seve...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.119.6.1676

    authors: Sonna LA,Angel KC,Sharp MA,Knapik JJ,Patton JF,Lilly CM

    更新日期:2001-06-01 00:00:00

  • Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)? The Dutch CNSLD Study Group. The Dutch Chronic Nonspecific Lung Disease Study Groups.

    abstract:BACKGROUND:The institution of inhaled corticosteroids is generally advocated for effective treatment of patients with asthma. It is yet unknown what is the best time to start inhaled corticosteroid therapy and especially whether delayed introduction is harmful. PHASE 1: In a previous study in patients with asthma and C...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.110.1.35

    authors: Overbeek SE,Kerstjens HA,Bogaard JM,Mulder PG,Postma DS

    更新日期:1996-07-01 00:00:00

  • Do radiographic criteria for emphysema predict physiologic impairment?

    abstract:OBJECTIVE:The functional consequences of pulmonary emphysema have been estimated from autopsy studies. This antemortem study correlates structure as assessed by criteria applied to chest radiographs and function in earlier disease. SUBJECTS AND METHODS:Four thousand one hundred seven male shipyard and construction wor...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.5.1225

    authors: Kilburn KH,Warshaw RH,Thornton JC

    更新日期:1995-05-01 00:00:00

  • Combined aortic and mitral valve replacement in an adult with Scheie's disease.

    abstract::Mitral, aortic, and coronary arterial disease have been described in the various mucopolysaccharidoses. We report the first successful combined aortic and mitral valve replacement in an adult female patient with severe aortic and mitral stenosis due to Scheie's syndrome, a mucopolysaccharide storage disease. Both annu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.1.209

    authors: Butman SM,Karl L,Copeland JG

    更新日期:1989-07-01 00:00:00

  • Tropical pulmonary eosinophilia.

    abstract::Tropical pulmonary eosinophilia (TPE) usually affects people living in the tropics, especially those in Southeast Asia, India, and certain parts of China and Africa. However, owing to the rising frequency of world-wide travel and the migration between continents, this disease is increasingly seen in the West, where th...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.6.1673

    authors: Ong RK,Doyle RL

    更新日期:1998-06-01 00:00:00

  • Interferon-related bronchiolitis obliterans organizing pneumonia.

    abstract::We present an unusual case of a patient with chronic hepatitis C who experienced dyspnea, fever, and cough after 2 1/2 months' treatment with interferon. His radiograph demonstrated diffuse pulmonary infiltrates and bronchoalveolar lavage fluid showed an increase in lymphocytes, especially CD8-positive cells. The lung...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.2.612

    authors: Ogata K,Koga T,Yagawa K

    更新日期:1994-08-01 00:00:00

  • Lower prevalence of positive atopic skin tests in lung cancer patients.

    abstract::Allergy prick skin testing was performed on 137 newly diagnosed patients with primary lung cancer and 137 age-(+/- 3 years) and sex-matched randomly selected control subjects. We also compared 38 patients with lung cancer and 38 of their closest in age, same-sex siblings. Demographic data, personal, medical, smoking a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.2.241

    authors: McDuffie HH,Cockcroft DW,Talebi Z,Klaassen DJ,Dosman JA

    更新日期:1988-02-01 00:00:00

  • Postinfluenza toxic shock syndrome.

    abstract::Postinfluenza toxic shock syndrome is a recently described entity that results from a respiratory tract infection with toxin-producing Staphylococcus aureus following an episode of influenza or influenzalike illness. This report describes a 19-year-old man who developed an influenza B respiratory infection complicated...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.95.5.1153

    authors: Prechter GC,Gerhard AK

    更新日期:1989-05-01 00:00:00

  • Usefulness of core roll preparations in immediate assessment of neoplastic lung lesions: comparison to conventional CT scan-guided lung fine-needle aspiration cytology.

    abstract:INTRODUCTION:CT scan-guided fine-needle aspiration (FNA) of lung nodules is a well-established diagnostic technique. In our institution, both FNA and tissue core biopsy (using a 20-gauge needle) under CT scan guidance are routinely performed during the same procedure, and a preliminary diagnosis (an immediate assessmen...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.126.3.739

    authors: Chandan VS,Zimmerman K,Baker P,Scalzetti E,Khurana KK

    更新日期:2004-09-01 00:00:00

  • Pulmonary section development influences general medical house officer interests and ABIM certifying examination performance.

    abstract::To determine whether sectional development in pulmonary and critical care medicine influences medical house officers' (HO) interests and knowledge about respiratory medicine, we reviewed HO performance on the American Board of Internal Medicine (ABIM) certifying examination during 4 years before and 5 years after reor...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.2.533

    authors: Haponik EF,Bowton DL,Chin R Jr,Adair NE,Lykens MG,Alford PT,Bass DA

    更新日期:1996-08-01 00:00:00

  • Reason-Giving and Medical Futility: Contrasting Legal and Social Discourse in the United States With the United Kingdom and Ontario, Canada.

    abstract::Disputes regarding life-prolonging treatments are stressful for all parties involved. These disagreements are appropriately almost always resolved with intensive communication and negotiation. Those rare cases that are not require a resolution process that ensures fairness and due process. We describe three recent cas...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2016.05.026

    authors: Bosslet GT,Baker M,Pope TM

    更新日期:2016-09-01 00:00:00

  • Inflammatory mediators in BAL fluid as markers of evolving pneumonia in leukocytopenic patients.

    abstract:STUDY OBJECTIVES:Pneumonia during chemotherapy-induced leukocytopenia is a major cause of overall treatment failure in patients with hematologic malignancies. To improve outcome in these high-risk patients, early diagnosis of pulmonary infiltrates and institution of adequate antimicrobial treatment are mandatory. To id...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.112.5.1214

    authors: Kiehl MG,Ostermann H,Thomas M,Birkfellner T,Kienast J

    更新日期:1997-11-05 00:00:00

  • Cough in Ambulatory Immunocompromised Adults: CHEST Expert Panel Report.

    abstract:BACKGROUND:Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However, it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating cond...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.07.039

    authors: Rosen MJ,Ireland B,Narasimhan M,French C,Irwin RS,CHEST Expert Cough Panel.

    更新日期:2017-11-01 00:00:00

  • Dynamics of left ventricular diastolic filling during exercise: a Doppler echocardiographic study of boys 10 to 14 years old.

    abstract:STUDY OBJECTIVE:Factors influencing diastolic filling of the left ventricle may serve as critical determinants of both maximal cardiac output and oxygen uptake. This study was conducted to assess diastolic filling dynamics of the left ventricle during progressive upright cycle exercise in children. METHODS:Twelve boys...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.1.145

    authors: Rowland T,Mannie E,Gawle L

    更新日期:2001-07-01 00:00:00

  • Hemoptysis due to MDI therapy in a patient with permanent tracheostomy: treatment with mask AeroChamber.

    abstract::Persistent minor hemoptysis resulted from extensive granulation tissue on the main carina and adjacent bronchi due to frequent spraying of metered-dose inhaler (MDI)-generated aerosol medications directly into a permanent tracheostomy. Salbutamol, containing oleic acid, was considered the most likely cause. After an A...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.1.279

    authors: Newhouse MT

    更新日期:1999-01-01 00:00:00

  • Natural history of tako-tsubo cardiomyopathy.

    abstract:BACKGROUND:Stress-induced or tako-tsubo cardiomyopathy (TTC) is a rare acute cardiac syndrome characterized by transient left ventricular (LV) dysfunction of uncertain cause and outcome. This study sought to assess the long-term outcome of patients with TTC. METHODS:One-hundred sixteen consecutive patients were prospe...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.10-1041

    authors: Parodi G,Bellandi B,Del Pace S,Barchielli A,Zampini L,Velluzzi S,Carrabba N,Gensini GF,Antoniucci D,Tuscany Registry of Tako-Tsubo Cardiomyopathy.

    更新日期:2011-04-01 00:00:00

  • Recovery of the ventilatory and upper airway muscles and exercise performance after type A botulism.

    abstract::We studied six patients with type A botulism to determine the degree of initial respiratory compromise and to quantitate the time course and extent of recovery of the ventilatory and upper airway muscles and exercise performance. The VM weakness was identified in all patients early after botulism. Upper airway muscle ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.3.620

    authors: Wilcox PG,Morrison NJ,Pardy RL

    更新日期:1990-09-01 00:00:00

  • The role of thoracic radiotherapy in the management of limited-stage small cell lung cancer: past, present, and future.

    abstract::The role of thoracic radiation therapy in the management of limited-stage small cell lung cancer (SCLC) is reviewed. Although chest irradiation has been used to treat SCLC for over four decades, its standard role in the management of limited-stage disease was established only during the last decade. Multiple prospecti...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.112.4_supplement.259s

    authors: Kumar P

    更新日期:1997-10-01 00:00:00

  • Methodologic standards for diagnostic test research in pulmonary medicine.

    abstract:STUDY OBJECTIVES:To determine conformance with methodologic standards in the evaluation of diagnostic tests. DATA SOURCES:MEDLINE database search (1992 to 1997) of nine prominent general medicine and six subspecialty journals for articles that report discriminative properties of diagnostic tests in pulmonary medicine....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.3.877

    authors: Heffner JE,Feinstein D,Barbieri C

    更新日期:1998-09-01 00:00:00

  • Pulmonary hyperinflation following Nd-YAG laser resection of an obstructing mainstem tumor.

    abstract::Nd-YAG laser resection of a completely obstructing right mainstem tumor in a 36-year-old man was complicated by right lung hyperinflation and left lung collapse and accompanying ventilatory failure. This was attributed to obstruction of the right mainstem bronchus during exhalation, but not inhalation, in a patent but...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.6.1302

    authors: Fairfax WR,Rollins RJ

    更新日期:1988-06-01 00:00:00

  • The utility of sonographic features during endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in patients with lung cancer: a standard endobronchial ultrasound image classification system.

    abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high yield for lymph node staging of lung cancer. The aim of this study was to assess the utility of sonographic features of lymph nodes during EBUS-TBNA for the prediction of metastasis in p...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-2006

    authors: Fujiwara T,Yasufuku K,Nakajima T,Chiyo M,Yoshida S,Suzuki M,Shibuya K,Hiroshima K,Nakatani Y,Yoshino I

    更新日期:2010-09-01 00:00:00

  • Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia.

    abstract:OBJECTIVE:To assess the effect of baseline variables, including treatment, on outcome in patients with nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). DESIGN:Retrospective analysis of data from two prospective, randomized, double-blind studies. SETTING:Multinational study with 134 site...

    journal_title:Chest

    pub_type: 杂志文章

    doi:

    authors: Wunderink RG,Rello J,Cammarata SK,Croos-Dabrera RV,Kollef MH

    更新日期:2003-11-01 00:00:00

  • The effect of a peak flow-based action plan in the prevention of exacerbations of asthma.

    abstract:STUDY OBJECTIVE:To determine the effect of a symptom-based and a peak flow-based action plan in preventing acute exacerbations in subjects with poorly controlled asthma. DESIGN:A randomized controlled trial in which subjects who had required urgent treatment for their asthma were allocated to receive no action plan, a...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.112.6.1534

    authors: Cowie RL,Revitt SG,Underwood MF,Field SK

    更新日期:1997-12-01 00:00:00