The lung in immunoblastic lymphadenopathy.

Abstract:

:Immunoblastic lymphadenopathy presents with fever, malaise, cough, dyspnea, lymphadenopathy, hepatosplenomegaly, hypergammaglobulinemia, interstitial pulmonary infiltrates, mediastinal adenopathy, and effusions. The diagnosis is made on the basis of lymph node biopsy. Based on the course in our patients and the cases presented in previous reports, a suggested program of treatment for immunoblastic lymphadenopathy includes administration of moderate doses of steroids initially, with a subsequent increase to a higher dosage if desired improvement does not occur. Chemotherapy with three drugs, cyclophosphamide, vincristine, and prednisone, is indicated if remission using steroids fails. The diagnostic dilemma of whether pulmonary infiltrates are due to the disease itself or to pulmonary infection or to cytotoxic changes from chemotherapy always exists and often requires specimens from either transbronchoscopic or open-lung biopsy for definitive diagnosis and treatment.

journal_name

Chest

journal_title

Chest

authors

Bradley SL,Dines DE,Banks PM,Hill RW

doi

10.1378/chest.80.3.312

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

312-8

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)39466-1

journal_volume

80

pub_type

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