Hypothalamic-pituitary-adrenal function in extrinsic asthma.

Abstract:

:Hypothalamic-pituitary-adrenal function in a well-defined, carefully selected group of 25 patients with extrinsic asthma was assessed by measuring plasma levels of adrenocorticotropic hormone (ACTH) and of 11-deoxycorticol after administration of metyrapone and by measuring the level of cortisol following stimulation with cosyntropin. No difference was demonstrated between asthmatic subjects and 20 normal age-matched controls. In addition, neither the response of the level of ACTH nor of 11-deoxycortisol correlated with the duration of asthma or the severity as assessed in 23 patients by tests of pulmonary function. We conclude that there is no abnormality in hypothalamic-pituitary-adrenal function in patients with extrinsic asthma, and we suggest that previous data suggesting such an abnormality may reflect heterogeneous groups of patients, inaccurate methods, and the variability of normal responses to ACTH and stimulation with metyrapone.

journal_name

Chest

journal_title

Chest

authors

Morrish DW,Sproule BJ,Aaron TH,Outhet D,Crockford PM

doi

10.1378/chest.75.2.161

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

161-6

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)30520-1

journal_volume

75

pub_type

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