Cholesterol in pleural effusions. A diagnostic aid.

Abstract:

:In this prospective study of 70 patients with pleural effusion, the underlying disease could be identified in 62 cases. By predefined criteria, 31 of these effusions were classified as transudates and 31 as exudates. Pleural fluid protein content, LDH activity and cholesterol level were measured to investigate their utility in differentiating the exudates from the transudates. Protein and LDH levels, and their pleural fluid-to-serum ratios, resulted in erroneous classification of 11 to 15 percent of the effusions. Mean cholesterol level in malignant effusions was 94 mg/dl, 76 mg/dl in inflammatory effusions and 30 mg/dl in the transudates. Using a dividing line of 60 mg/dl to separate the exudates from the transudates, only 5 percent were incorrectly classified. Elevated cholesterol levels in exudates seem to be independent of the serum levels. Our findings indicate that the pleural fluid cholesterol level is a simple and cost-effective aid in differentiating exudative from transudative pleural effusions.

journal_name

Chest

journal_title

Chest

authors

Hamm H,Brohan U,Bohmer R,Missmahl HP

doi

10.1378/chest.92.2.296

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

296-302

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)43459-2

journal_volume

92

pub_type

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