Pathologic and radiologic differences between idiopathic and collagen vascular disease-related usual interstitial pneumonia.


BACKGROUND:Patients with usual interstitial pneumonia (UIP) associated with collagen vascular disease (CVD) have been reported to have a better prognosis than those with idiopathic pulmonary fibrosis with a UIP pattern (IPF/UIP) seen on histology. The aim of this study was to evaluate the pathologic and radiologic differences between the two conditions and their relationship with clinical outcome. METHODS:A retrospective review of 100 patients (CVD-UIP, 39 patients; IPF/UIP, 61 patients) with UIP pattern diagnosed by surgical lung biopsy at one tertiary referral center. RESULTS:The median follow-up period was 34.4 months. The CVD-UIP group was younger, included more women and nonsmokers, and showed better survival than the IPF/UIP group. Pathologically, CVD-UIP patients had fewer fibroblastic foci and smaller honeycombing (HC) spaces with higher germinal centers and total inflammation scores than IPF/UIP patients. Radiologically, CVD-UIP patients had a lower emphysema score and more likely a nontypical UIP pattern without HC. The germinal centers score was the best distinguishing feature between CVD-UIP and IPF/UIP patients (odds ratio, 2.948; p = 0.001) and was marginally related to survival (p = 0.076). The HC score (hazard ratio [HR], 1.134; p < 0.001), total lung capacity (TLC) [HR, 0.932; p = 0.004], and age (HR, 1.052; p = 0.017) were significant predictors of survival in all patients with UIP histology, regardless of the presence of CVD. Among IPF/UIP patients, those with positive autoantibodies were pathologically more similar to CVD-UIP than to IPF/UIP without autoantibodies, despite no difference in survival between them. CONCLUSIONS:The germinal centers score was the best discriminative between CVD-UIP and IPF/UIP patients; it was of marginal prognostic significance. Age, TLC, and HC score were independent prognostic factors in all patients with UIP histology.






Song JW,Do KH,Kim MY,Jang SJ,Colby TV,Kim DS




Has Abstract


2009-07-01 00:00:00
















  • Cardiac tamponade secondary to giant lymph node hyperplasia (Castleman's disease)

    abstract::A unique association of giant lymph node hyperplasia (Castleman's disease) and cardiac tamponade is presented. Although pleural effusions have been previously described with Castleman's disease, the authors believe this to be the first report of pericardial effusion and tamponade with this entity. The development of e...


    pub_type: 杂志文章


    authors: Nicolosi AC,Almassi GH,Komorowski R

    更新日期:1994-02-01 00:00:00

  • Low and High Blood Eosinophil Counts as Biomarkers in Hospitalized Acute Exacerbations of COPD.

    abstract:BACKGROUND:Characterizing acute exacerbations of COPD (AECOPD) and individualizing therapy is challenging. Key exacerbation therapies include antibiotics and systemic corticosteroids. Blood eosinophils, when either low or high, may offer a simple, inexpensive distinction to predict beneficial responses to these therapi...


    pub_type: 杂志文章,多中心研究


    authors: MacDonald MI,Osadnik CR,Bulfin L,Hamza K,Leong P,Wong A,King PT,Bardin PG

    更新日期:2019-07-01 00:00:00

  • Snoring, nocturnal hypoxemia, and the effect of oxygen inhalation.

    abstract::Men who snore heavily have an increased incidence of hypertension, angina, stroke, and neuropsychologic dysfunction, which may be due to nocturnal oxygen desaturation. Nocturnal oxygen therapy might be beneficial to such individuals by improving oxygenation and relieving tissue hypoxia. Twenty-eight asymptomatic heavy...


    pub_type: 杂志文章


    authors: Block AJ,Hellard DW,Cicale MJ

    更新日期:1987-09-01 00:00:00

  • Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.

    abstract:STUDY OBJECTIVES:To determine the selective vasodilatory effects of two inhaled "NONOate" aerosols in a closed chest pig model of acute pulmonary hypertension (APH). METHODS:APH was induced by IV infusion of the prostaglandin H(2)/thromboxane A(2) receptor agonist (U46619). Aerosolized diethylenetriamine nitric oxide ...


    pub_type: 杂志文章


    authors: Lam CF,van Heerden PV,Ilett KF,Caterina P,Filion P

    更新日期:2003-03-01 00:00:00

  • The Coronavirus Disease 2019 Pandemic's Effect on Critical Care Resources and Health-Care Providers: A Global Survey.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has severely affected ICUs and critical care health-care providers (HCPs) worldwide. RESEARCH QUESTION:How do regional differences and perceived lack of ICU resources affect critical care resource use and the well-being of HCPs? STUDY DESIGN AND METHODS:Betw...


    pub_type: 杂志文章


    authors: Wahlster S,Sharma M,Lewis AK,Patel PV,Hartog CS,Jannotta G,Blissitt P,Kross EK,Kassebaum NJ,Greer DM,Curtis JR,Creutzfeldt CJ

    更新日期:2020-09-11 00:00:00

  • Massive pulmonary emboli in children: does fiber-optic-guided embolectomy have a role? Review of the literature and report of two cases.

    abstract::Massive pulmonary emboli is a rare disease in children, with only 39 reported cases in the last 50 years. Almost 50% of the patients died suddenly without receiving medical treatment. Most of the patients who were managed medically (70% of the treated patients) underwent surgical pulmonary embolectomy with 80% surviva...


    pub_type: 杂志文章,评审


    authors: Eini ZM,Houri S,Cohen I,Sion R,Tamir A,Sasson L,Mandelberg A

    更新日期:2013-02-01 00:00:00

  • Mortality probability model III and simplified acute physiology score II: assessing their value in predicting length of stay and comparison to APACHE IV.

    abstract:BACKGROUND:To develop and compare ICU length-of-stay (LOS) risk-adjustment models using three commonly used mortality or LOS prediction models. METHODS:Between 2001 and 2004, we performed a retrospective, observational study of 11,295 ICU patients from 35 hospitals in the California Intensive Care Outcomes Project. We...


    pub_type: 杂志文章,多中心研究


    authors: Vasilevskis EE,Kuzniewicz MW,Cason BA,Lane RK,Dean ML,Clay T,Rennie DJ,Vittinghoff E,Dudley RA

    更新日期:2009-07-01 00:00:00

  • Is protected specimen brush a reproducible method to diagnose ICU-acquired pneumonia?

    abstract:UNLABELLED:Protected specimen brush (PSB) is considered to be one of the standard methods for the diagnosis of ventilator-associated pneumonia, but to our knowledge, intraindividual variability in results has not been reported previously. PURPOSE:To compare the results of two PSB performed in the same subsegment on pa...


    pub_type: 杂志文章


    authors: Timsit JF,Misset B,Francoual S,Goldstein FW,Vaury P,Carlet J

    更新日期:1993-07-01 00:00:00

  • Cardiopulmonary exercise testing in children: an individualized protocol for workload increase.

    abstract:OBJECTIVES:To investigate the feasibility of individualized workload increments, as used in adults, for exercise testing in children; and to investigate whether this individualized protocol makes it possible to satisfy the usual criteria for maximal exercise (clinical exhaustion, predicted maximum heart rate [HRmax], o...


    pub_type: 杂志文章


    authors: Karila C,de Blic J,Waernessyckle S,Benoist MR,Scheinmann P

    更新日期:2001-07-01 00:00:00

  • Prediction of successful ventilator weaning using airway occlusion pressure and hypercapnic challenge.

    abstract::We studied eleven patients during 14 attempts at weaning from mechanical ventilation to determine whether central ventilatory drive, measured as airway occlusion pressure 0.1 s after onset of inspiration (P 0.1), during spontaneous breathing before and during a brief hypercapnic challenge, could accurately predict the...


    pub_type: 杂志文章


    authors: Montgomery AB,Holle RH,Neagley SR,Pierson DJ,Schoene RB

    更新日期:1987-04-01 00:00:00

  • Repetitive ventricular fibrillation preceded by both ST segment depression and elevation during acute myocardial ischemia.

    abstract::A patient had repetitive ventricular fibrillation preceded by alternating ST segment depression and elevation. The ECG changes were confined to the precordial leads only, reflecting subendocardial and transmural ischemia, respectively. It is speculated that the patient exhibited consecutive episodes of subtotal and to...


    pub_type: 杂志文章


    authors: Rechavia E,Sagie A,Kusniec J,Mager A,Sclarovsky S

    更新日期:1988-06-01 00:00:00

  • Proadrenomedullin improves Risk of Early Admission to ICU score for predicting early severe community-acquired pneumonia.

    abstract:BACKGROUND:Whether proadrenomedullin (ProADM) improves the performance of the Risk of Early Admission to ICU (REA-ICU) score in predicting early, severe community-acquired pneumonia (ESCAP) has not been demonstrated. METHODS:Secondary analysis was completed of the original data from 877 consecutive patients with commu...


    pub_type: 杂志文章,多中心研究


    authors: Renaud B,Schuetz P,Claessens YE,Labarère J,Albrich W,Mueller B

    更新日期:2012-12-01 00:00:00

  • Complete endobronchial occlusion by Kaposi's sarcoma in the absence of cutaneous involvement.

    abstract::Bronchopulmonary Kaposi's sarcoma (KS) occurs in 20 percent of AIDS patients with cutaneous involvement; however, complete endobronchial occlusion is uncommon. Moreover, bronchopulmonary KS is infrequent in the absence of cutaneous manifestations. We report a case of documented complete endobronchial obstruction by KS...


    pub_type: 杂志文章


    authors: Chin R Jr,Jones DF,Pegram PS,Haponik EF

    更新日期:1994-05-01 00:00:00

  • Dyphylline aerosol attenuates antigen-induced bronchoconstriction in experimental canine asthma.

    abstract::This study compared the bronchodilator effect in experimental canine asthma of dyphylline administered by aerosol and intravenous routes in doses producing equivalent concentrations of the drug in the plasma. Pulmonary resistance (RL) was calculated from simultaneous measurements of pressure and flow during fixed-volu...


    pub_type: 杂志文章


    authors: Hirshman CA,Lawyer C,Downes H,Farbood A,Rodgers R,Gerber N

    更新日期:1981-04-01 00:00:00

  • A 60-year-old woman with cough, dyspnea, and atelectasis 19 years after liver transplant.

    abstract::A 60-year-old black woman presented with nonproductive cough of 1-month duration. She had also experienced rapidly progressive dyspnea for 1 week and one bout of vomiting a day before presentation. Her symptoms had failed to improve with a course of amoxicillin-clavulanate. Her medical history was significant for diab...


    pub_type: 杂志文章


    authors: Panchabhai TS,Bandyopadhyay D,Alraiyes AH,Mehta AC,Almeida FA

    更新日期:2015-10-01 00:00:00

  • Transition from exercise to rest. Ventilatory and arterial blood gas responses.

    abstract::The mechanisms leading to rapid changes in arterial blood gas values soon after exercise ends have not been well established. To further study these phenomena, we exercised seven normal male volunteers to exhaustion on a cycle ergometer with a 25-W/min ramped protocol measuring arterial blood gas values, and breath-by...


    pub_type: 杂志文章


    authors: O'Neill AV,Johnson DC

    更新日期:1991-05-01 00:00:00

  • Angioimmunoblastic lymphadenopathy presenting as superior vena caval obstruction.

    abstract::A 60-year-old man presented with features of superior vena cava (SVC) obstruction. On evaluation, he was diagnosed as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). SVC obstruction due to AILD, to our knowledge, has not been described. ...


    pub_type: 杂志文章


    authors: Sanghvi S,Kothari AS,Hathi BC,Sharma RG

    更新日期:1991-12-01 00:00:00

  • Pre- and postoperative pulmonary function abnormalities in coronary artery revascularization surgery.

    abstract::Pulmonary function studies were conducted one to two days prior to, two weeks after, and an average of 116 days after coronary artery revascularization surgery. Preoperation it was found that 11 of 19 patients had mild to moderate obstruction, 8 of 17 had diffusing capacity less than 80 percent of predicted, and 9 of ...


    pub_type: 杂志文章


    authors: Braun SR,Birnbaum ML,Chopra PS

    更新日期:1978-03-01 00:00:00

  • A 72-Year-Old Man With a Violaceous Rash and Sepsis.

    abstract:CASE PRESENTATION:A 72-year-old man presented to our ED less than 24 hours following the acute onset of nausea, vomiting, and diarrhea. Within 12 hours of symptom onset, he noted bilateral lower extremity pain and swelling. His pain was associated with a new violaceous irregular rash on the anterior aspect of both feet...




    authors: Gittens AT,Clarke JD,Abdelbaki S,Kwon JS

    更新日期:2020-02-01 00:00:00

  • Pulse transit time improves detection of sleep respiratory events and microarousals in children.

    abstract:OBJECTIVES:To evaluate the additional information provided by pulse transit time (PTT), a noninvasive tool, when using during polysomnography for the diagnosis of sleep breathing disorders in a pediatric population. MAIN FINDINGS:Respiratory and microarousals events were scored twice. The first scoring was performed u...


    pub_type: 杂志文章


    authors: Pépin JL,Delavie N,Pin I,Deschaux C,Argod J,Bost M,Levy P

    更新日期:2005-03-01 00:00:00

  • Effect of a nasogastric tube on esophageal pressure measurement in normal adults.

    abstract::We studied the correspondence between fluctuations of esophageal pressure measured before and after placement of a nasogastric (NG) tube in six normal volunteers. Flow, airway pressure, and esophageal pressure data from at least 20 breaths were recorded in seven ventilatory conditions in two body postures: 0 degree (s...


    pub_type: 杂志文章


    authors: Niknam J,Chandra A,Adams AB,Nahum A,Ravenscraft SA,Marini JJ

    更新日期:1994-07-01 00:00:00

  • The Future of Lung Transplantation.

    abstract::The field of lung transplant has made significant advances over the last several decades. Despite these advances, morbidity and mortality remain high when compared with other solid organ transplants. As the field moves forward, the speed by which progress can be made will in part be determined by our ability to overco...


    pub_type: 杂志文章,评审


    authors: Young KA,Dilling DF

    更新日期:2019-03-01 00:00:00

  • Effect of continuous positive airway pressure on the rapid shallow breathing index in patients following cardiac surgery.

    abstract:OBJECTIVES:To compare the rapid shallow breathing index (RSBI) under different ventilatory support settings prior to extubation trials. DESIGN:Prospective study. SETTING:Cardiac surgery unit at a university hospital. PATIENTS:A total of 33 coronary artery bypass grafting patients ready for extubation. INTERVENTIONS...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: El-Khatib MF,Jamaleddine GW,Khoury AR,Obeid MY

    更新日期:2002-02-01 00:00:00

  • Video-assisted contralateral treatment for bronchial stump diastasis after left pneumonectomy.

    abstract::Postoperative bronchial stump failure is a life-threatening complication, and several surgical approaches and procedures have been developed to close the stump. In this report, we describe a case of left mainstem bronchial stump diastasis after pneumonectomy for lung cancer, in which the bronchial stump was re-closed ...


    pub_type: 杂志文章


    authors: Tsunezuka Y,Sato H,Kodama T

    更新日期:2000-03-01 00:00:00

  • Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy.

    abstract:BACKGROUND:We sought to determine the efficacy and safety of perioperative treatment with methylprednisolone on the development of lung injury after pulmonary thromboendarterectomy. METHODS:This was a randomized, prospective, double-blind, placebo-controlled study of 98 adult patients with chronic thromboembolic pulmo...


    pub_type: 杂志文章,随机对照试验


    authors: Kerr KM,Auger WR,Marsh JJ,Devendra G,Spragg RG,Kim NH,Channick RN,Jamieson SW,Madani MM,Manecke GR,Roth DM,Shragg GP,Fedullo PF

    更新日期:2012-01-01 00:00:00

  • Whole-lung lavage in alveolar proteinosis by a modified lavage technique.

    abstract::Whole-lung lavage is the only efficient treatment in pulmonary alveolar proteinosis. A 36-year-old woman with severe pulmonary alveolar proteinosis confirmed by video-assisted thoracoscopic lung biopsies underwent repetitive whole-lung lavages without improvement. A modified technique consisting of manual ventilation ...


    pub_type: 杂志文章


    authors: Bingisser R,Kaplan V,Zollinger A,Russi EW

    更新日期:1998-06-01 00:00:00

  • Re-evaluation of bone marrow aspiration in the diagnosis of miliary tuberculosis.

    abstract::We studied eight patients with miliary tuberculosis (TB). In all instances, tuberculomatous lesions were demonstrated in the aspirated bone marrow. We conclude that the bone marrow aspiration has great value in diagnosing miliary TB because it provides sufficient material to permit examination of serial sections as ne...


    pub_type: 杂志文章


    authors: Kinoshita M,Ichikawa Y,Koga H,Sumita S,Oizumi K

    更新日期:1994-09-01 00:00:00

  • Pulmonary developmental anomaly associated with Klippel-Feil syndrome and anomalous atrioventricular conduction.

    abstract::We report the findings in a patient with Klippel-Feil syndrome and associated agenesis of right upper and middle lobes, hypoplasia of the right lower lobe of the lung, and Lown-Ganong-Levine syndrome. To our knowledge, such an association has not been previously described. ...


    pub_type: 杂志文章


    authors: Bhagat R,Pant K,Singh VK,Pant C,Gupta A,Jaggi OP

    更新日期:1992-04-01 00:00:00

  • Time course of hemosiderin production and clearance by human pulmonary macrophages.

    abstract::Tracheal aspirates from four previously healthy infants with acute pulmonary hemorrhage, and small volume bronchial lavages from children undergoing flexible fiberoptic bronchoscopy were examined for pulmonary alveolar macrophages (PAM) containing hemosiderin. Hemosiderin formation was also studied in vitro. Macrophag...


    pub_type: 杂志文章


    authors: Sherman JM,Winnie G,Thomassen MJ,Abdul-Karim FW,Boat TF

    更新日期:1984-09-01 00:00:00

  • Underreading of the tuberculin skin test reaction.

    abstract:STUDY OBJECTIVE:The tuberculin skin test is the best diagnostic method to detect tuberculous infection. How accurate is interpretation of the test? DESIGN:Observational study. SETTING:Both general hospital and university hospital. PARTICIPANTS:One hundred seven health-care professionals, including 52 practicing pedi...


    pub_type: 杂志文章


    authors: Kendig EL Jr,Kirkpatrick BV,Carter WH,Hill FA,Caldwell K,Entwistle M

    更新日期:1998-05-01 00:00:00