Abstract:
:To assess the responsiveness of the cerebral vessels to chronic hypercapnia, we measured middle cerebral artery flow velocity by transcranial Doppler ultrasound in 20 normal subjects and in 14 COLD patients before and after stimulation by progressive hypercapnia (rebreathing test) or by intravenous administration of an acetazolamide bolus. The results showed no statistically significant difference in baseline flow velocity between the normal subjects and the COLD patients. The COLD patients showed a reduced cerebral vascular responsiveness to both stimuli. Cerebral blood flow is normal in chronic hypercapnia and the mechanism by which compensation is achieved leads to a decrease in cerebral vascular responsiveness.
journal_name
Chestjournal_title
Chestauthors
Clivati A,Ciofetti M,Cavestri R,Longhini Edoi
10.1378/chest.102.1.135subject
Has Abstractpub_date
1992-07-01 00:00:00pages
135-8issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)35857-3journal_volume
102pub_type
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