Abstract:
:Normal subjects were exposed to an aerosol of Escherichia coli endotoxin. Carbon monoxide diffusion (Dco), spirometry, blood neutrophils, white blood cells, and platelets were determined at various times thereafter. A significant decrease in Dco and an increase in blood neutrophils was found, with a maximum effect 4 to 8 h after exposure. Exposure to distilled water caused a tendency for Dco to decrease and a significant increase in blood neutrophils. No effect on spirometry or body temperature was detected. It is suggested that the changes observed represent an inflammation at the alveolar level that appears at dose levels of endotoxin below those which cause bronchoconstriction and fever.
journal_name
Chestjournal_title
Chestauthors
Herbert A,Carvalheiro M,Rubenowitz E,Bake B,Rylander Rdoi
10.1378/chest.102.4.1095subject
Has Abstractpub_date
1992-10-01 00:00:00pages
1095-8issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(16)34285-4journal_volume
102pub_type
杂志文章相关文献
CHEST文献大全abstract:BACKGROUND:Skeletal muscle dysfunction occurring as a result of ICU admission associates with higher mortality. Although preadmission higher BMI correlates with better outcomes, the impact of baseline muscle and fat mass has not been defined. We therefore investigated the association of skeletal muscle and fat mass at ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.10.023
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Cigarette smoking is associated with worse symptoms in asthma and abnormal segmental airways in healthy subjects. We tested the hypothesis that current symptom control in smokers with asthma is associated with altered segmental airway dimensions measured by CT scan. METHODS:In 93 subjects with mild, moderat...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-1119
更新日期:2015-03-01 00:00:00
abstract::The literature on pulmonary function testing in sarcoidosis is critically reviewed. The results indicate that pulmonary function tests are not a reliable means for detecting the presence of parenchymal sarcoidosis, nor do they provide an accurate estimate of the extent of parenchymal disease. There are at present no k...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.4.640
更新日期:1980-10-01 00:00:00
abstract::Pulmonary embolism (PE) is a common disorder that is accompanied by significant morbidity and mortality. Although anticoagulation is the standard treatment for PE, thrombolytic therapy, with its ability to produce rapid clot lysis, has long been considered an attractive alternative. Although many studies have been per...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.115.6.1695
更新日期:1999-06-01 00:00:00
abstract::A 53-year-old woman with a large pericardial effusion and tamponade presented with signs of IHSS including a grade 4/6 apical systolic murmur, severe SAM, early systolic aortic valve closure and a small hypercontractile left ventricle but at most borderline left ventricular hypertrophy. Following pericardiocentesis, t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.91.4.631
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVES:Studies documenting the increased incidence of exercise-induced bronchospasm (EIB) in figure skaters have employed a method that incorporates on-ice exercise with rink-side spirometry. The literature suggests that bronchial provocation challenge testing is better than exercise testing for identifying EIB. To...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.3.649
更新日期:1999-03-01 00:00:00
abstract::Rupture of the left ventricular free wall after acute myocardial infarction (AMI) has been regarded as uniformly fatal unless emergency surgical repair is performed. Among 2,862 patients admitted with AMI to our ICU during the last 8 years, 107 patients developed rupture of the left ventricular free wall. Twenty-nine ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.2.565
更新日期:1996-02-01 00:00:00
abstract::The need for fiberoptic bronchoscopy in the patient with hemoptysis and a normal or nonlocalizing chest roentgenogram remains a subject of debate. Currently, diagnostic fiberoptic bronchoscopy is recommended as the investigative procedure of choice. To develop predictors that identify the patient in whom fiberoptic br...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.1.70
更新日期:1988-01-01 00:00:00
abstract::Six young cocaine users, median age 35.5 years (range 27 to 44 years) experienced acute myocardial infarction. The close temporal correlation in two cases between cocaine use and clinical infarction and the relative paucity of atherosclerotic blockage of the coronary arteries in the others, as demonstrated by autopsy ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.5.729
更新日期:1984-11-01 00:00:00
abstract:STUDY OBJECTIVE:Oral theophylline treatment may be helpful in controlling severe asthma during pregnancy. This treatment, however, has been suspected of causing both complications and malformations. The objective of this investigation was to study the influence of theophylline treatment on the course of pregnancy and d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.3.642
更新日期:1995-03-01 00:00:00
abstract::Nineteen consecutive patients with clinically suspected sarcoidosis underwent 67Ga-scintigraphy prior to transbronchial lung biopsy (TBLB) to determine if 67Ga uptake in lung parenchyma would increase the diagnostic yield of the biopsy procedure. Biopsies were obtained from the areas showing parenchymal uptake on the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.82.1.7
更新日期:1982-07-01 00:00:00
abstract:STUDY OBJECTIVES:To examine the main therapeutic response patterns to high doses of salbutamol and to determine the factors that contribute to outcome in acute severe asthma. SETTING:The emergency department (ED) of a large, urban hospital with primary and referral care responsibilities. PATIENTS AND DESIGN:One hundr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.3.593
更新日期:1998-03-01 00:00:00
abstract:STUDY OBJECTIVES:Although inhaled beta2-agonists are in widespread use, several reports question their potential arrhythmogenic effects. The purpose of this study was to evaluate the cardiac electrophysiologic effects of a single, regular dose of an inhaled beta2-agonist in humans. DESIGN:Prospective study. SETTING:T...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.6.2057
更新日期:2005-06-01 00:00:00
abstract::To determine if a regimen of intravenous and oral corticosteroids reduces the relapse rate after treatment of decompensated COPD in the ED, 30 patients were studied. Forty-five visits in which intravenous and oral corticosteroids were given (T visits) were compared with an equal number of matched visits in which they ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.4.845
更新日期:1990-10-01 00:00:00
abstract::A case of subaortic stenosis caused by two discrete membranes is presented. Following demonstration of the two distinct sites of obstruction by intraventricular pressure gradients and angiocardiogram, the two membranes were excised through a transaortic approach. The importance of being aware of the occurrence of this...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.1.104
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2017.05.011
更新日期:2017-11-01 00:00:00
abstract::In November 2007, the Josiah Macy, Jr. Foundation convened a conference to address a number of complex issues concerning continuing education (CE) in the health professions. Participants concluded that CE, as currently practiced, does not focus adequately on improving clinician performance and patient care, is too dep...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-1022
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The incidence and outcomes of disseminated intravascular coagulation (DIC) are incompletely defined. Therefore, we aimed to evaluate the trends in incidence and outcomes of critically ill patients with DIC. METHODS:We conducted a population-based, retrospective cohort study evaluating consecutively admitted...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2112
更新日期:2013-05-01 00:00:00
abstract::In patients with acquired or congenital heart diseases, the systolic pulmonary artery pressure (PAPs) can be predicted using continuous-wave Doppler ultrasound (CWD) measurement of the peak velocity of a tricuspid regurgitation (TR) jet. The aim of this study was to determine whether CWD could be used to accurately es...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.6.1258
更新日期:1989-12-01 00:00:00
abstract::A patient with the sick sinus syndrome accompanying mirror-image dextrocardia which was associated with double superior venae cavae and an absent inferior vena cava is presented. A permanent transvenous demand pacemaker was inserted because of repeated episodes of dizziness and a documented 31/2-second period of asyst...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.4.558
更新日期:1976-04-01 00:00:00
abstract::To assess the value of bronchoalveolar lavage (BAL) for diagnosis, understanding, and treatment of amiodarone-associated pneumonitis, we examined the results of BAL total and differential cell counts and phenotyping of lymphocytes in 22 patients with this lung disorder and in 33 normal subjects. Overall, the total cel...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.5.1177
更新日期:1991-05-01 00:00:00
abstract::The long-term pulmonary consequences of right middle lobe syndrome (RMLS) in childhood are not known. Therefore, outcome was evaluated in 17 children with RMLS diagnosed in early childhood (mean age, 3.3 years; SD, 1.1 year). Mean age at follow-up was 10.1 years (SD, 2.6 years). RMLS was defined as atelectasis of the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.1.150
更新日期:1995-07-01 00:00:00
abstract::We studied the incidence and mechanisms of cardiovascular complications and postoperative respiratory insufficiency associated with GA and Nd:YAG laser endobronchial tumor resection. The records of 73 patients undergoing 87 procedures were reviewed. Preoperative status, anesthetic methods and perioperative complicatio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.1.72
更新日期:1991-01-01 00:00:00
abstract::A transcutaneous oxygen sensor was used to detect the development of hypoxemia in patients undergoing fiberoptic bronchoscopy. Measurements of transcutaneous PO2 (tcPO2) correlated well with arterial PO2 (PaO2), and correctly detected all instances when PaO2 was less than 65 mm Hg. The sensor was noninvasive and cause...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.89.4.543
更新日期:1986-04-01 00:00:00
abstract::Pulmonary function studies were performed before and after one-time administration of an inhaled bronchodilator to ascertain the relative diagnostic value of using FVC, FEF25-75%, static lung volumes, Raw, and/or sGaw measurements, in addition to the FEV1, to assess the reversibility of chronic airways obstruction in ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.541
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Chlorofluorocarbons (CFCs) used as propellants in metered-dose inhalers deplete stratospheric ozone, which results in serious public health concerns. Albuterol has been reformulated in the non-ozone-depleting propellant, hydrofluoroalkane-134a (HFA albuterol). OBJECTIVES:The primary objective was to compare...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.115.4.945
更新日期:1999-04-01 00:00:00
abstract::An original method of treatment for main bronchus fistula occurring after pneumonectomy was described in 1961. The operation is performed via a median sternotomy and the carinal region exposed. The main bronchi can then be divided in an area not involved with infection. We describe ten patients who underwent this proc...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.2.379
更新日期:1989-02-01 00:00:00
abstract::A protocol was originally designed to study breathing control during and following cardiac arrest in humans, taking advantage of the period of pulseless ventricular fibrillation (PVF) produced while testing a newly implanted cardioverter-defibrillator device. A patient aged in his 60s with New York Heart Association c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.12-2950
更新日期:2013-10-01 00:00:00
abstract::The effects of one hour exposures of healthy nonsmoking human volunteers to submicrometer H2SO4 droplets via nasal mask on tracheobronchial mucociliary particle clearance were studied using two different sized monodisperse gamma-tagged Fe2O3 test aerosols. The larger sized Fe2O3 aerosol, 7.5 micrometers AMAD, was depo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.80.6.873
更新日期:1981-12-01 00:00:00
abstract::The aim of this study was to investigate whether the demonstration of plasma cells (PC), which are normally absent in bronchoalveolar lavage (BAL) fluid, facilitates differentiation among pulmonary disorders. Initial BAL fluid samples of 1,260 patients were analyzed. In 83 of these, PC were found. Of these 83, 47 were...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.6.1720
更新日期:1993-06-01 00:00:00