Abstract:
:We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of corticosteroid therapy was 5.4 days and the mean total dose was 660 mg of methylprednisolone. Cryptococcus neoformans and Listeria monocytogenes infection each occurred once within one month of therapy in corticosteroid-treated patients; no other noteworthy acute corticosteroid toxicity was noted. Since all patients with imminently lethal PCP received corticosteroids, we could not assess the effect of these agents on acute mortality. After six months the rates of new AIDS-related diagnoses and of post-hospitalization mortality were equivalent in the two groups. We also have critically reviewed the available literature regarding this use of corticosteroids.
journal_name
Chestjournal_title
Chestauthors
Lambertus MW,Goetz MB,Murthy AR,Mathisen GEdoi
10.1378/chest.98.1.38subject
Has Abstractpub_date
1990-07-01 00:00:00pages
38-43issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)41226-2journal_volume
98pub_type
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