Complications of corticosteroid therapy in patients with the acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia.

Abstract:

:We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of corticosteroid therapy was 5.4 days and the mean total dose was 660 mg of methylprednisolone. Cryptococcus neoformans and Listeria monocytogenes infection each occurred once within one month of therapy in corticosteroid-treated patients; no other noteworthy acute corticosteroid toxicity was noted. Since all patients with imminently lethal PCP received corticosteroids, we could not assess the effect of these agents on acute mortality. After six months the rates of new AIDS-related diagnoses and of post-hospitalization mortality were equivalent in the two groups. We also have critically reviewed the available literature regarding this use of corticosteroids.

journal_name

Chest

journal_title

Chest

authors

Lambertus MW,Goetz MB,Murthy AR,Mathisen GE

doi

10.1378/chest.98.1.38

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

38-43

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)41226-2

journal_volume

98

pub_type

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