Abstract:
BACKGROUND:Lung transplantation is a good therapeutic option for end-stage lung disease. Data on thromboembolic complications following lung transplantation are scarce. STUDY OBJECTIVES:To evaluate the incidence of thromboembolic events following lung transplantation, and to determine their possible association with hypercoagulable state. DESIGN:Retrospective study in a single, tertiary-care, university-affiliated referral center. SUBJECTS AND METHOD:The records of 70 patients who underwent lung transplantation in our institution between September 1997 and September 2003 were reviewed for thromboembolic complications. Parameters pertaining to risk of thrombophilia were measured in the patients with thromboembolic complications. RESULTS:Thromboembolic complications developed in 6 of the 70 patients (8.6%) at 4 to 24 months after transplantation: deep vein thrombosis (DVT) in 2 patients, pulmonary embolism (PE) in 1 patient, both DVT and PE in 1 patient, and retinal vein thrombosis in 2 patients. The fibrinogen level was elevated in all six patients, and factor VIII, IX, and/or XI levels were elevated in five patients. Heterozygosity for 5 10-methylene tetrahydrofolate reductase was documented in two patients, and mutation for factor II or factor V-Leiden mutation was found in one patient. Levels of protein C and protein S and activated protein C resistance were within normal range in all patients. Four patients had mildly elevated levels of at least one antiphospholipid antibody; none had a positive lupus anticoagulant test result. Overall, all patients demonstrated abnormalities on hypercoagulability tests. CONCLUSIONS:Thromboembolic complications occur at a high rate (8.6%) in lung transplant recipients and are associated with abnormalities in hypercoagulability. The cause remains unclear. Our results should prompt a high index of suspicion for these potentially fatal complications, which would lead to early diagnosis and successful treatment.
journal_name
Chestjournal_title
Chestauthors
Izbicki G,Bairey O,Shitrit D,Lahav J,Kramer MRdoi
10.1378/chest.129.2.412subject
Has Abstractpub_date
2006-02-01 00:00:00pages
412-6issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)38765-1journal_volume
129pub_type
杂志文章相关文献
CHEST文献大全abstract::Two rules of good graphs are presented and explicated. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.130.2.620
更新日期:2006-08-01 00:00:00
abstract:CASE PRESENTATION:A 69-year-old man consulted for a 3-day history of fever, wet cough, and yellow-green phlegm. He denied having any dyspnea, chest pain, hemoptysis, swallowing disorders, choke, chills, asthenia, anorexia, or weight loss. He reported a continuous dry cough and three episodes of pneumonia in the past 4 ...
journal_title:Chest
pub_type:
doi:10.1016/j.chest.2020.07.033
更新日期:2020-12-01 00:00:00
abstract::The preponderance of evidence indicates that high airway pressure is not by itself injurious to the lung. Rather, overdistention of the lung appears to be the fundamental mechanism underlying VALI. The physician must bear in mind the factors (ie, flow-resistive pressure losses, respiratory muscle activity, and abnorma...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.105.1.242
更新日期:1994-01-01 00:00:00
abstract::Chemical sclerosis of the pleural space is used to prevent recurrence of spontaneous pneumothorax. To test whether sclerosis restricts diaphragmatic excursion, we measured diaphragmatic excursion by ultrasonography in subjects with unilateral pleural sclerosis and compared it with diaphragmatic excursions in normal su...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.2.374
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:We sought to determine the impact of OSA syndrome (OSAS) on symptoms and quality of life (QoL) among patients with posttraumatic stress disorder (PTSD). In addition, we assessed adherence and response to positive airway pressure (PAP) therapy in this population. METHODS:This was a case-controlled observatio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0693
更新日期:2016-02-01 00:00:00
abstract::The determination of effective dynamic and static relationships between pressure and volume aided in the diagnosis of pulmonary disease, its course, and the effects of therapy in 22 patients receiving continuous mechanical ventilation. These measurements were made on multiple occasions early in the course of mechanica...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.70.6.740
更新日期:1976-12-01 00:00:00
abstract::Thirty-three patients with T3,N2,M0 or T4,N2,M0, non-small-cell lung cancer (NSCLC) took part in a phase 2 study in an attempt to evaluate the feasability of neoadjuvant chemotherapy followed by surgery and thoracic radiotherapy. Chemotherapy consisted of daily administration of the following treatment: etoposide, 100...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.106.5.1451
更新日期:1994-11-01 00:00:00
abstract::Bronchial stump fistula occurred on the seventh postoperative day in a 45-year-old man who underwent right pneumonectomy for T2N2M0 adenocarcinoma of the lung. It was attributable to ventilator-related barotrauma during treatment of ARDS from multiple pulmonary emboli. A frequently lethal complication, its presentatio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.654
更新日期:1988-03-01 00:00:00
abstract::Measurement of lung volumes is an integral part of complete pulmonary function testing. Some lung volumes can be measured during spirometry; however, measurement of the residual volume (RV), functional residual capacity (FRC), and total lung capacity (TLC) requires special techniques. FRC is typically measured by one ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-2964
更新日期:2012-08-01 00:00:00
abstract::To assess the diagnostic value of telescoping plugged catheters (TPC) in human immunodeficiency virus (HIV)-infected patients with pulmonary infiltrates (PI), we performed a prospective clinical study in 71 episodes of fever and PI in 66 HIV-infected patients (five patients had two different episodes of fever and PI)....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.1.76
更新日期:1992-07-01 00:00:00
abstract:STUDY OBJECTIVES:To analyze the physiologic effects and tolerance of mechanical insufflation-exsufflation (MI-E) by means of mechanical cough assistance (Cough Assist; JH Emerson Company; Cambridge, MA) for children with neuromuscular disease. DESIGN:Prospective clinical trial. SETTING:Physiology laboratory of a pedi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.07-1615
更新日期:2008-01-01 00:00:00
abstract::We present a case in which the radiographic appearance of a bipolar pacing lead mimics a wire fracture. Recognition of this normal finding--due to lead construction--will help avoid erroneous diagnosis of wire fracture on chest x-ray films. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.2.302
更新日期:1985-08-01 00:00:00
abstract::The effect of combined administration of different dose ratios of dobutamine (DB) and dopamine (DA) (DB/DA ratio of 1:1; 1.5:0.5; 2:0; 0.5:1.5; and 0:2), with the added dose kept constant (10 micrograms/kg/min-20 micrograms/kg/min), on right ventricular function (measured by the thermal washout method with the aid of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.5.1197
更新日期:1992-05-01 00:00:00
abstract::The concentrations of gentamicin, netilmicin, and amikacin were determined after one single intravenous injection in uninfected pleural fluid after thoracotomy and in purulent pleural empyemas. The mean peak concentrations in the pleural fluid after the injection of gentamicin (1.5 mg/kg), netilmicin (2.0 mg/kg), and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.530
更新日期:1988-03-01 00:00:00
abstract:STUDY OBJECTIVES:Poor dental hygiene has been linked to respiratory pathogen colonization in residents of long-term care facilities. We sought to investigate the association between dental plaque (DP) colonization and lower respiratory tract infection in hospitalized institutionalized elders using molecular genotyping....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.5.1575
更新日期:2004-11-01 00:00:00
abstract::A patient is reported who had Histoplasma capsulatum endocarditis, a rare form of disseminated histoplasmosis. He also had disseminated intravascular coagulopathy and defects in cell-mediated immune responses to Histoplasma antigens. Prompt etiologic diagnosis was made by stain of tissue from a mouth ulcer and confirm...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.5.791
更新日期:1980-11-01 00:00:00
abstract::Indirect evidence from airway pressure recordings in mechanically ventilated patients suggests that the diaphragm exhibits contractile activity beyond that required to trigger a ventilator-assisted breath. We used the diaphragmatic EMG to provide direct evidence of persistent contractile activity and studied the effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.1.130
更新日期:1989-07-01 00:00:00
abstract::In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.101.3.810
更新日期:1992-03-01 00:00:00
abstract::We investigated 654 subjects of a small Lombardy (Italy) town between 15 and 64 years of age who were representative of the general population. By clinical examination, the sample included 535 normal subjects (164 normal smokers, 341 normal nonsmokers, 30 normal subjects with acute upper respiratory illness within 30 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.1.26
更新日期:1988-01-01 00:00:00
abstract::The timing of surgical treatment of empyema remains controversial. Traditionally, thoracotomy is performed either within three weeks of diagnosis or delayed until presumed pleurodesis occurs. Often, these patients are moribund and the duration of illness impossible to determine. We report our surgical results in seven...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.4.511
更新日期:1986-10-01 00:00:00
abstract::Clinically apparent involvement of the nervous system occurs in a relatively small number of patients with sarcoidosis. The diagnosis of neurosarcoidosis is often difficult and particularly so in patients who lack either pulmonary or systemic manifestations of sarcoidosis. Furthermore, clinical features of neurosarcoi...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.112.1.220
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:The diagnosis of sarcoidosis is made by the combination of clinical features and biopsy results. The clinical features of sarcoidosis can be quite variable. We developed a Sarcoidosis Diagnostic Score (SDS) to summarize the clinical features of patients with possible sarcoidosis. METHODS:Biopsy-confirmed pa...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.05.003
更新日期:2018-11-01 00:00:00
abstract::Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and baby. Tobacco use during pregnancy has decreased in high-income countries but not in Indigenous women in Australia, New Zealand, the United States, and Canada. ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2017.06.033
更新日期:2017-10-01 00:00:00
abstract::Forty-seven cases of quadricuspid semilunar valves which were autopsied were reviewed. The ratio of quadricuspid pulmonic valve to quadricuspid aortic valve was 5:1. Among the 35 patients with quadricuspid pulmonic valves, there were ten patients with clinical and pathologic evidence of coexisting congenital cardiac d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.2.186
更新日期:1977-08-01 00:00:00
abstract::To determine if respiratory maneuvers may enhance the response to inhaled bronchodilator drugs, we evaluated the bronchodilator responses when isoproterenol was: inhaled as a bolus high (80 percent VC) compared to low (20 percent VC) lung volumes, and inhaled as a single 800 microgram dose compared to four 200 microgr...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.76.5.501
更新日期:1979-11-01 00:00:00
abstract:OBJECTIVE:To study the effect of intravenous (i.v.) terbutaline on potassium (K) and magnesium (Mg) distribution, ECG changes, and prevalence of ventricular ectopic beats in healthy subjects. DESIGN:Randomized double-blind, placebo-controlled crossover. Subjects received either placebo or terbutaline (bolus, 0.25 mg; ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.106.6.1654
更新日期:1994-12-01 00:00:00
abstract::Postinfluenza toxic shock syndrome is a recently described entity that results from a respiratory tract infection with toxin-producing Staphylococcus aureus following an episode of influenza or influenzalike illness. This report describes a 19-year-old man who developed an influenza B respiratory infection complicated...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.95.5.1153
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:It would be valuable to have a noninvasive method of measuring impaired pulmonary gas exchange in patients with lung disease and thus reduce the need for repeated arterial punctures. This study reports the results of using a new test in a group of outpatients attending a pulmonary clinic. METHODS:Inspired a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.02.001
更新日期:2018-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect of a symptom-based and a peak flow-based action plan in preventing acute exacerbations in subjects with poorly controlled asthma. DESIGN:A randomized controlled trial in which subjects who had required urgent treatment for their asthma were allocated to receive no action plan, a...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.112.6.1534
更新日期:1997-12-01 00:00:00
abstract:STUDY OBJECTIVES:To assess the functional sequelae (FS) of patients with tuberculous pleurisy (TP), to analyze the influence of different factors in the occurrence of these FS, and, finally, to evaluate the relationship between the FS and roentgenographic sequelae. DESIGN:An observational, retrospective study. SETTIN...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.6.1996
更新日期:2003-06-01 00:00:00