Abstract:
INTRODUCTION:CD14 is a cell surface glycoprotein expressed mainly on mature monocytes and macrophages. Soluble CD14 (sCD14) is present in normal plasma and is found increased in serum of patients with septicemia, polytrauma, and sarcoidosis. In active sarcoidosis, increased levels of sCD14 in BAL supernatant have been demonstrated. STUDY OBJECTIVE:To investigate sCD14 levels in BAL of pulmonary tuberculosis (PTB), another inflammatory disease characterized by granuloma formation. METHODS:BAL was performed in 12 patients with active but untreated PTB and 12 healthy persons. Cytologic and immunocytologic characteristics were determined. sCD14 was measured by a sandwich enzyme-linked immunosorbent assay. RESULTS:The level of sCD14 in patients with PTB was increased compared with controls (mean +/- SEM: 34.4 +/- 9.6 ng/mL vs 11.5 +/- 2.2 ng/mL; p = 0.02). No correlation was found between sCD14 levels and BAL cell differentials or lymphocyte surface markers. CONCLUSION:Similar to sarcoidosis, increased levels of sCD14 are found in BAL supernatant of PTB patients.
journal_name
Chestjournal_title
Chestauthors
Hoheisel G,Zheng L,Teschler H,Striz I,Costabel Udoi
10.1378/chest.108.6.1614subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1614-6issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(15)45117-7journal_volume
108pub_type
杂志文章相关文献
CHEST文献大全abstract::Proteomics is the study of the entire protein complement of the genome (the proteome) in a biological system. Proteomic studies require a multidisciplinary approach and have only been practical with the convergence of technical and methodologic improvements including the following: advances in mass spectrometry and ge...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.130.2.567
更新日期:2006-08-01 00:00:00
abstract:STUDY OBJECTIVES:The management of stable patients with COPD depends on the severity of symptoms and airflow limitation. Regarding inflammation, corticosteroids are the only medications that are recommended for use, and only under restricted circumstances. Corticosteroids tend to undertreat or overtreat patients with C...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.2.375
更新日期:2004-08-01 00:00:00
abstract::The measurement of the activity of acid hydrolases and of alkaline phosphatase in bronchial aspirates obtained through bronchoscopic procedures from a series of 300 patients forms the basis for a screening program to diagnose bronchial malignant neoplasms more effectively. We define such a screening test as one permit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.2.150
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:No studies have attempted to examine the genetic influence on the habit of snoring. The aim of the present study was to examine whether an association existed between self-reported snoring and family history of snoring and a number of genetic markers. MATERIAL AND METHODS:The data were derived from a primar...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.5.1289
更新日期:1995-05-01 00:00:00
abstract::A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual asso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1.111
更新日期:1980-07-01 00:00:00
abstract:STUDY OBJECTIVES:To investigate intracranial pressure (ICP) changes and their mechanisms in chronic hypercapnia. DESIGN:After 12 male Wistar rats were maintained in CO2-mixed air (mean PaCO2, 71.0 mm Hg) for 21 weeks, their ICP levels were measured during the breathing of 0, 5, 10, 12, and 14% CO2-mixed air before and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.5.1402
更新日期:1999-05-01 00:00:00
abstract::We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of cort...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.38
更新日期:1990-07-01 00:00:00
abstract::Aortic intramural hematoma (IMH) is related to but is pathologically distinct from aortic dissection. In this potentially lethal entity, there is hemorrhage into the aortic media in the absence of an intimal tear. Although intimal disruption is not present, the prognosis is similar to that of classic aortic dissection...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.120.4.1340
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Acute respiratory tract infections (ARTIs) are among the main causes of morbidity and mortality in children. The bacterial extract OM-85 BV (bronchovaxom) has shown protective effect for ARTIs on children. We report a double-blind, placebo-controlled, parallel, prospective clinical trial to assess the safety...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.119.6.1742
更新日期:2001-06-01 00:00:00
abstract::Data from various different types of cross-sectional studies are reviewed in order to examine hypotheses about the etiology of asthma and to more precisely define its relationship with nonspecific bronchial hyperreactivity (NSBH). Although cross-sectional studies have not clarified the precise etiologic links, they ha...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.91.6_supplement.114s
更新日期:1987-06-01 00:00:00
abstract::Cardiac imaging with dipyridamole infusion has been proposed as an exercise-independent tool for the diagnosis of coronary artery disease. Dipyridamole acts through the accumulation of adenosine, which reduces sympathetic tone in vasomotor nuclei of the brainstem and inhibits norepinephrine release in noradrenergic ne...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.102.2.444
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited response to currently available therapies. Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury. However, in IPF, ATII cells die and are replace...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.03.021
更新日期:2016-09-01 00:00:00
abstract::We studied eight patients with miliary tuberculosis (TB). In all instances, tuberculomatous lesions were demonstrated in the aspirated bone marrow. We conclude that the bone marrow aspiration has great value in diagnosing miliary TB because it provides sufficient material to permit examination of serial sections as ne...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.3.690
更新日期:1994-09-01 00:00:00
abstract::Extrinsic compression of the left main coronary artery (LMCA) can occur in patients with severe pulmonary hypertension and enlarged pulmonary artery trunk. It has been usually described in the setting of congenital defects such as atrial septal defect, ventricular septal defect, and, more rarely, isolated persistent d...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.08-2922
更新日期:2009-06-01 00:00:00
abstract::Repeated aortic prosthetic valve endocarditis and aortic root abscesses were successfully treated by implantation of a valved conduit into the ascending aorta and by placement of saphenous vein grafts to the aorta distal to the conduit and to the right and left anterior descending coronary arteries. This procedure pro...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.85.6.832
更新日期:1984-06-01 00:00:00
abstract::The potential for significant interaction between PEEP and the peripheral microcirculations is not as well appreciated as are its central circulatory effects. Therefore, we studied the effects of PEEP, 15 mm Hg, on microvascular fluid flux in the hindlimb of ten mature sheep. Changes in prefemoral lymph flow (QL) and ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.5.1142
更新日期:1989-11-01 00:00:00
abstract:STUDY OBJECTIVES:The aim was to evaluate demographic, clinical, and laboratory variables in febrile patients, with or without a microbiologically confirmed infection, for prediction of death, in comparison to the systemic inflammatory response syndrome (SIRS) and its criteria, such as abnormal temperature, tachycardia,...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.6.1533
更新日期:1998-06-01 00:00:00
abstract::The definition of a standard therapy for resectable esophageal cancer remains a clinical controversy. In the past decade, a variety of strategies have been developed in an attempt to improve local control and decrease the all too common problem of distant metastases. Preoperative treatment with radiotherapy or chemoth...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.116.suppl_3.466s
更新日期:1999-12-01 00:00:00
abstract::A ventricular inhibited unipolar pacing system in a case of so-called pacemaker syndrome was successfully converted into an atrioventricular sequential system without replacing the ventricular lead. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.3.436
更新日期:1980-03-01 00:00:00
abstract::The history holds the central role in distinguishing among asthma, chronic bronchitis, and emphysema. A personal or family history of atopy, a history of seasonal worsening of disease in response to a known environmental agent, perhaps seasonal, and marked variability in the severity of airflow obstruction, often with...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.87.1.35s
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Club cell secretory protein (CCSP) is a protective biomarker associated with annual decline in lung function. COPD progression results from an imbalance between injury and repair initially triggered by cigarette smoking. OBJECTIVE:We investigated the effect of CCSP as a therapeutic strategy to restore the b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-1174
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Acquired somatic mutations induced by oxidative stress may contribute to the molecular pathogenesis of chronic inflammatory airway diseases. The objective of this study was to assess the intensity of oxidative DNA damage and the presence of microsatellite DNA instability (MSI), a marker of acquired somatic m...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-1653
更新日期:2012-05-01 00:00:00
abstract::Although nearly 3,000 e-cigarette-related hospitalizations have been reported in North America, the long-term outcomes in these patients have not been described. We followed an 18-year-old boy who survived acute critical illness and respiratory failure related to 5 months of e-cigarette use. Chronic irreversible airfl...
journal_title:Chest
pub_type:
doi:10.1016/j.chest.2020.06.005
更新日期:2020-10-01 00:00:00
abstract::The pulmonary status of 178 asymptomatic asthmatic children with normal time-volume spirograms was further evaluated using flow-volume loops, body plethysmographic studies, and blood gas tensions in arterialized capillary blood. Residual volume (RV) was abnormal in 26%, total lung capacity (TLC) in 33%, RV/TLC% in 41%...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.71.3.361
更新日期:1977-03-01 00:00:00
abstract:STUDY OBJECTIVES:There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in clinical CO poisoning (range, 36 to 131 min, respectively). Other rep...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.117.3.801
更新日期:2000-03-01 00:00:00
abstract:STUDY OBJECTIVE:We assessed the usefulness of endobronchial ultrasonography in the determination of the depth of tumor invasion of the tracheobronchial wall. METHODS:We performed a needle-puncture experiment on normal tissue of 45 specimens to determine the laminar structure of the tracheobronchial wall. In addition, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.6.1500
更新日期:1999-06-01 00:00:00
abstract::Airway pressure release ventilation (APRV), a new ventilatory support technique, was compared with conventional intermittent positive-pressure ventilation plus PEEP (CPPV) in 18 patients with severe acute respiratory failure. Patients were initially stabilized on CPPV and then switched to APRV. The APRV provided effec...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.2.460
更新日期:1991-08-01 00:00:00
abstract::To determine if the timing of interposed abdominal compressions (IAC) affects the augmented blood flow during this form of cardiopulmonary resuscitation (CPR), we performed early-onset or late-onset abdominal compressions at three vascular volumes in nine dogs. Early-onset IAC began immediately following chest compres...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.6.1206
更新日期:1988-06-01 00:00:00
abstract::A 20-year-old woman developed severe shortness of breath 4 h after a cesarean section. Chest roentgenogram showed a pleural effusion and tension pneumothorax; insertion of a chest tube drained liquid stool. At surgery she was found to have a left diaphragmatic defect with herniation, strangulation, and perforation of ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.3.950
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Eosinophils contain granule proteins such as eosinophil cationic protein (ECP) that have proinflammatory effects on airways. ECP may be released on activation of eosinophils into the plasma and is widely used as a marker of bronchial hyperreactivity and allergic inflammation. Environmental factors as well as...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.121.4.1111
更新日期:2002-04-01 00:00:00