A pharmacologic study on CO2 responsiveness of intracranial pressure in rats with chronic hypercapnia.

Abstract:

STUDY OBJECTIVES:To investigate intracranial pressure (ICP) changes and their mechanisms in chronic hypercapnia. DESIGN:After 12 male Wistar rats were maintained in CO2-mixed air (mean PaCO2, 71.0 mm Hg) for 21 weeks, their ICP levels were measured during the breathing of 0, 5, 10, 12, and 14% CO2-mixed air before and after the i.v. administration of nitro-L-arginine methyl ester (L-NAME). The ICP responses to i.v. norepinephrine and i.v. adenosine were also tested. Ten rats that were maintained in room air served as the control group. RESULTS:The mean ICP in the study group (5.9 mm Hg) was not significantly different from the mean ICP in the control group. In the study group, the ICP response to changes in PaCO2 was significantly blunted when compared to the response seen in the control group. In both groups, i.v. norepinephrine significantly increased the ICP. In the control group but not in the study group, i.v. L-NAME suppressed the ICP response to changes in PaCO2. In both groups, i.v. adenosine significantly increased the ICP. CONCLUSIONS:The ICP response to PaCO2 was blunted in rats with chronic hypercapnia, and the mechanism of this reduced response may involve nitric oxide.

journal_name

Chest

journal_title

Chest

authors

Kondo T,Kumagai M,Takei F,Ohta Y

doi

10.1378/chest.115.5.1402

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

1402-6

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)35300-9

journal_volume

115

pub_type

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