Occult pulmonary abnormalities in asymptomatic asthmatic children.

Abstract:

:The pulmonary status of 178 asymptomatic asthmatic children with normal time-volume spirograms was further evaluated using flow-volume loops, body plethysmographic studies, and blood gas tensions in arterialized capillary blood. Residual volume (RV) was abnormal in 26%, total lung capacity (TLC) in 33%, RV/TLC% in 41%, and arterial oxygen pressure in 23% of them. All values for expiratory flow measured relative to observed vital capacity (VC), (ie, the forced expiratory volume in one second [FEV1], the mean forced expiratory flow during the middle half of the forced vital capacity [FEF25-75%; FVC], FEV1/VC, and the instantaneous forced expiratory flow after 75% and after 50% of the FVC has been exhaled) were normal, and VC was subnormal in only five instances, but flow rates measured relative to TLC were abnormal in 26% of the patients. Some abnormality of pulmonary function was present in all but 13% of these asymptomatic children. Reliance upon conventional evaluation of pulmonary function by forced expiratory spirograms and freedom from wheezing may frequently give the clinician a false impression of the true conditon of the lungs of the asthmatic child.

journal_name

Chest

journal_title

Chest

authors

Cooper DM,Cutz E,Levison H

doi

10.1378/chest.71.3.361

subject

Has Abstract

pub_date

1977-03-01 00:00:00

pages

361-5

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)40389-2

journal_volume

71

pub_type

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