Abstract:
STUDY OBJECTIVE:Cysteinyl leukotrienes are important proinflammatory mediators in the pathogenesis of asthma. Since bronchial hyperresponsiveness is a noninvasive surrogate marker of asthmatic airway inflammation, we evaluated the bronchoprotection afforded by leukotriene receptor antagonists (LTRAs). DESIGN:Systematic review of randomized, placebo-controlled trials in which LTRAs were administered for >or= 5 days. Studies in which active drug was administered as a first-line or second-line therapy were used. SETTING:MEDLINE, BIDS, and Cochrane Library data registers. MEASUREMENTS:The doubling dose/dilution difference that caused a 20% fall in the FEV(1) between LTRA and placebo. RESULTS:Thirteen trials (353 subjects) fulfilled eligibility criteria. Combining the results the overall weighted estimated protection amounted to a 0.85 doubling dose shift (95% confidence interval, 0.69 to 1.02). CONCLUSION:Since the estimated protection amounted to almost one doubling dose, this reinforces the role of LTRAs as anti-inflammatory therapy in asthma.
journal_name
Chestjournal_title
Chestauthors
Currie GP,Lipworth BJdoi
10.1378/chest.122.1.146subject
Has Abstractpub_date
2002-07-01 00:00:00pages
146-50issue
1eissn
0012-3692issn
1931-3543pii
S0012-3692(16)46291-4journal_volume
122pub_type
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