Bronchoprotective effects of leukotriene receptor antagonists in asthma: a meta-analysis.

Abstract:

STUDY OBJECTIVE:Cysteinyl leukotrienes are important proinflammatory mediators in the pathogenesis of asthma. Since bronchial hyperresponsiveness is a noninvasive surrogate marker of asthmatic airway inflammation, we evaluated the bronchoprotection afforded by leukotriene receptor antagonists (LTRAs). DESIGN:Systematic review of randomized, placebo-controlled trials in which LTRAs were administered for >or= 5 days. Studies in which active drug was administered as a first-line or second-line therapy were used. SETTING:MEDLINE, BIDS, and Cochrane Library data registers. MEASUREMENTS:The doubling dose/dilution difference that caused a 20% fall in the FEV(1) between LTRA and placebo. RESULTS:Thirteen trials (353 subjects) fulfilled eligibility criteria. Combining the results the overall weighted estimated protection amounted to a 0.85 doubling dose shift (95% confidence interval, 0.69 to 1.02). CONCLUSION:Since the estimated protection amounted to almost one doubling dose, this reinforces the role of LTRAs as anti-inflammatory therapy in asthma.

journal_name

Chest

journal_title

Chest

authors

Currie GP,Lipworth BJ

doi

10.1378/chest.122.1.146

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

146-50

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)46291-4

journal_volume

122

pub_type

杂志文章,meta分析

相关文献

CHEST文献大全
  • Influence of autonomic neuropathy of different severities on the hypercapnic drive to breathing in diabetic patients.

    abstract::To investigate the effects of the autonomic nervous system on control of breathing, the neuromuscular (mouth occlusion pressure at 0.1 s after onset of inspiration [P0.1]) and ventilatory (minute ventilation [VE]) response to progressive hyperoxic hypercapnia was assessed in diabetic patients with autonomic dysfunctio...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.112.1.145

    authors: Tantucci C,Scionti L,Bottini P,Dottorini ML,Puxeddu E,Casucci G,Sorbini CA

    更新日期:1997-07-01 00:00:00

  • Adjuvant Chemotherapy for Early-Stage Non-small Cell Lung Cancer.

    abstract::Lung cancer is the leading cause of cancer-related mortality in the developed world. Non-small cell lung cancer (NSCLC) represents 85% of cases of lung cancer, and patients have a poor 5-year survival rate. Approximately one third of NSCLC patients present with early-stage disease that is amenable to potentially curat...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.128.4.2933

    authors: Visbal AL,Leighl NB,Feld R,Shepherd FA

    更新日期:2005-10-01 00:00:00

  • The therapeutic potential of nitric oxide in lung transplantation.

    abstract::Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously adm...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.5.1360

    authors: Meyer KC,Love RB,Zimmerman JJ

    更新日期:1998-05-01 00:00:00

  • Radiation Exposure in the Medical ICU: Predictors and Characteristics.

    abstract:BACKGROUND:Patients admitted to the medical ICU (MICU) are often subjected to multiple radiologic studies. We hypothesized that some endure radiation dose exposure (cumulative effective dose [CED]) in excess of annual US federal occupational health standard limits (CED ≥ 50 mSv) and 5-year cumulative limit (CED ≥ 100 m...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2018.01.019

    authors: Krishnan S,Moghekar A,Duggal A,Yella J,Narechania S,Ramachandran V,Mehta A,Adhi F,Vijayan AKC,Han X,Wang X,Dong F,Martin C 3rd,Guzman J

    更新日期:2018-05-01 00:00:00

  • Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy.

    abstract:BACKGROUND:We sought to determine the efficacy and safety of perioperative treatment with methylprednisolone on the development of lung injury after pulmonary thromboendarterectomy. METHODS:This was a randomized, prospective, double-blind, placebo-controlled study of 98 adult patients with chronic thromboembolic pulmo...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.10-2639

    authors: Kerr KM,Auger WR,Marsh JJ,Devendra G,Spragg RG,Kim NH,Channick RN,Jamieson SW,Madani MM,Manecke GR,Roth DM,Shragg GP,Fedullo PF

    更新日期:2012-01-01 00:00:00

  • Sputum trace metals are biomarkers of inflammatory and suppurative lung disease.

    abstract:BACKGROUND:Induced sputum cytology and protein biomarkers can be used to assess airways inflammation. Increases in sputum iron have been described in inflammatory lung disease. We hypothesized that other sputum metals may be affected by airways inflammation and investigated their potential value as biomarkers. METHODS...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-1047

    authors: Gray RD,Duncan A,Noble D,Imrie M,O'Reilly DS,Innes JA,Porteous DJ,Greening AP,Boyd AC

    更新日期:2010-03-01 00:00:00

  • Diagnosis of pneumothorax by ultrasound immediately after ultrasonically guided aspiration biopsy.

    abstract::We report two cases of pneumothorax detected by echographic examination immediately after ultrasonically guided aspiration biopsy and confirmed by chest x-ray film. The pneumothorax was characterized by the disappearance of the lung tumor. In the real-time image, the respiratory excursions of the visceral pleura also ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.3.855

    authors: Targhetta R,Bourgeois JM,Chavagneux R,Balmes P

    更新日期:1992-03-01 00:00:00

  • Postnasal drip causes cough and is associated with reversible upper airway obstruction.

    abstract::We prospectively evaluated nine patients with cough from postnasal drip for evidence of extrathoracic upper airway obstruction. Patients compared before treatment to normal control subjects had physiologic evidence of extrathoracic upper airway obstruction; their mean FIF50%/FEF50% and FIF25-75%/FEF25-75% ratios of 0....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.85.3.346

    authors: Irwin RS,Pratter MR,Holland PS,Corwin RW,Hughes JP

    更新日期:1984-03-01 00:00:00

  • Differential coronary calcification on electron-beam CT between syndrome X and coronary artery disease in patients with chronic stable angina pectoris.

    abstract:STUDY OBJECTIVES:The differential diagnosis of syndrome X and coronary artery disease (CAD) in patients with evidence of myocardial ischemia may be difficult. The possible difference in coronary calcium detected by electron-beam CT (EBCT) between syndrome X and CAD is rarely evaluated, especially in aged patients with ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.120.5.1525

    authors: Chen LC,Chen JW,Wu MH,Liu JC,Lan GY,Ding PY,Chang MS

    更新日期:2001-11-01 00:00:00

  • Biopsy excision through a fiberoptic bronchoscope in the palliative management of airway obstruction.

    abstract::Simple biopsy resection through the rigid bronchoscope has been described in the past. We successfully performed such resection through a flexible bronchoscope in six patients with symptomatic and relatively less vascular lesions without complications. In selected patients simple biopsy resection of endobronchial lesi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.5.774

    authors: Mehta AC,Livingston DR

    更新日期:1987-05-01 00:00:00

  • Role of chest physicians in detection and treatment of occupational and environmental respiratory disease. A practice survey.

    abstract::A survey of American College of Chest Physicians (ACCP) members was conducted to determine their degree of involvement in the diagnosis and prevention of occupational and environmental respiratory disease (OERD). Although the response rate was relatively low, the results are likely to be representative. Calculations b...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.4.1156

    authors: Harber P,Scanlon PD,do Pico G,Garshick E

    更新日期:1995-04-01 00:00:00

  • Bronchial hyperreactivity in patients with mitral stenosis before and after successful percutaneous mitral balloon valvulotomy.

    abstract:OBJECTIVES:We aimed to identify the bronchial response to inhaled methacholine in patients with mitral stenosis (MS) and to clarify whether or not the bronchial hyperreactivity (BHR) is reversible after percutaneous mitral balloon valvulotomy (PBMV). PATIENTS AND SETTING:Thirty patients with MS and 28 age-matched heal...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.6.1582

    authors: Gülec S,Ertas F,Tutar E,Demirel Y,Karaoguz R,Omurlu K,Oral D

    更新日期:1999-12-01 00:00:00

  • Management of pediatric acute hypoxemic respiratory insufficiency with bilevel positive pressure (BiPAP) nasal mask ventilation.

    abstract:OBJECTIVES:To evaluate the efficacy and complications of noninvasive nasal mask bilevel continuous positive airway pressure ventilation in pediatric patients with hypoxemic respiratory insufficiency. DESIGN:Retrospective chart review. SETTING:Intensive care unit, university affiliated tertiary care children's hospita...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.4.1059

    authors: Fortenberry JD,Del Toro J,Jefferson LS,Evey L,Haase D

    更新日期:1995-10-01 00:00:00

  • Clinical characteristics and outcome of severe melioidosis requiring intensive care.

    abstract:STUDY OBJECTIVE:To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN:Retrospective chart review. SETTING:Two ICUs from a tertiary-care teaching hospital. PATIENTS:Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTER...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.5.3674

    authors: Chan KP,Low JG,Raghuram J,Fook-Chong SM,Kurup A

    更新日期:2005-11-01 00:00:00

  • Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia.

    abstract:STUDY OBJECTIVES:The Fas-Fas ligand (FasL) pathway is a representative system of apoptosis-signaling receptor molecules. We previously described that this pathway may play an important role in the pathogenesis of fibrosing lung diseases. In this study, we hypothesized that soluble form of Fas (sFas) and FasL (sFasL) ma...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.451

    authors: Kuwano K,Kawasaki M,Maeyama T,Hagimoto N,Nakamura N,Shirakawa K,Hara N

    更新日期:2000-08-01 00:00:00

  • Beliefs among pulmonologists and thoracic surgeons in the therapeutic approach to non-small cell lung cancer.

    abstract:STUDY OBJECTIVES:The physicians who initially evaluate patients with non-small cell lung cancer (NSCLC) strongly impact the course of therapy. Their beliefs in treatment and prognosis may contribute to practices of variable quality and appropriateness. We sought to better describe beliefs among pulmonologists and thora...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.1.129

    authors: Schroen AT,Detterbeck FC,Crawford R,Rivera MP,Socinski MA

    更新日期:2000-07-01 00:00:00

  • The relationship of sleepiness and blood pressure to respiratory variables in obstructive sleep apnea.

    abstract::As a follow-up to a previous assessment of complications of sleep-disturbed breathing in 265 patients, we have reevaluated measures of sleepiness and hypertension in patients with obstructive sleep apnea (OSA) (n = 518), central sleep apnea (n = 50), and subclinical sleep-disordered breathing (SDB) (n = 107). Both sub...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.4.966

    authors: Mendelson WB

    更新日期:1995-10-01 00:00:00

  • Homogeneity of bronchopulmonary distribution of 99mTc aerosol in normal subjects and in cystic fibrosis patients.

    abstract::We characterized the bronchopulmonary distribution of a 0.9 percent saline aerosol (1.12 microM) labelled with 99mTc sulfur colloid in nine normal subjects and five patients with CF. Homogeneity of distribution was quantified using indices derived from computerized analysis of Anger camera pulmonary images including s...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.4.822

    authors: Laube BL,Links JM,LaFrance ND,Wagner HN Jr,Rosenstein BJ

    更新日期:1989-04-01 00:00:00

  • Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure.

    abstract:STUDY OBJECTIVES:There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in clinical CO poisoning (range, 36 to 131 min, respectively). Other rep...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.117.3.801

    authors: Weaver LK,Howe S,Hopkins R,Chan KJ

    更新日期:2000-03-01 00:00:00

  • Clinical significance of a multiple biomarker assay in patients with lung cancer. A study with logistic regression analysis.

    abstract::The relative usefulness of a combination of some tumor markers, such as CEA, AFP, ferritin and NSE for the diagnosis of lung cancer was assessed by multiple logistic analysis. Serum concentration of these markers was determined in 68 patients with lung cancer (50 with NSCLC and 18 with SCLC, in 68 patients with benign...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.3.639

    authors: Lombardi C,Tassi GF,Pizzocolo G,Donato F

    更新日期:1990-03-01 00:00:00

  • Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock.

    abstract:STUDY OBJECTIVE:To examine the hemodynamic and metabolic short-term effects of hypophosphatemia correction in patients with septic shock receiving catecholamine therapy. DESIGN:Prospective, single cohort study. SETTING:ICU, university hospital. PATIENTS:Ten patients with septic shock and hypophosphatemia below 2 mg/...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.6.1698

    authors: Bollaert PE,Levy B,Nace L,Laterre PF,Larcan A

    更新日期:1995-06-01 00:00:00

  • Immediate hypersensitivity to tuberculin. In vivo and in vitro studies.

    abstract::Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occur...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.1.33

    authors: Tarlo SM,Day JH,Mann P,Day MP

    更新日期:1977-01-01 00:00:00

  • Efficacy of positive vs negative pressure ventilation in unloading the respiratory muscles.

    abstract::We compared the efficacy of positive pressure ventilation (PPV) vs negative pressure ventilation (NPV) in providing ventilatory muscle rest for five normal subjects and six patients with chronic obstructive pulmonary disease (COPD). All participants underwent measurement of transdiaphragmatic pressure (Pdi), pressure ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.4.850

    authors: Belman MJ,Soo Hoo GW,Kuei JH,Shadmehr R

    更新日期:1990-10-01 00:00:00

  • Tension fecal pneumothorax in a postpartum patient.

    abstract::A 20-year-old woman developed severe shortness of breath 4 h after a cesarean section. Chest roentgenogram showed a pleural effusion and tension pneumothorax; insertion of a chest tube drained liquid stool. At surgery she was found to have a left diaphragmatic defect with herniation, strangulation, and perforation of ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.3.950

    authors: Lacayo L,Taveras JM 3rd,Sosa N,Ratzan KR

    更新日期:1993-03-01 00:00:00

  • The effect of inflammation on mucociliary clearance in asthma: an overview.

    abstract::Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus....

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.118.4.1142

    authors: Del Donno M,Bittesnich D,Chetta A,Olivieri D,Lopez-Vidriero MT

    更新日期:2000-10-01 00:00:00

  • Rheumatoid nodules in the trachea.

    abstract::We describe the first case of endotracheal rheumatoid nodules in a 45-year-old Chinese man with rheumatoid arthritis. He developed exacerbation of polyarthritis, new subcutaneous nodules and fibrosing alveolitis. At bronchoscopy, four whitish nodules were detected at the tracheal wall, and biopsy showed fibrinoid necr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.1.301

    authors: Ip MS,Wong MP,Wong KL

    更新日期:1993-01-01 00:00:00

  • The prevalence and predictors of respiratory-related work limitation and occupational disability in an international study.

    abstract:BACKGROUND:Work-related symptoms and disability due to respiratory disease are common and costly among working-age adults. To investigate this problem, we analyzed data on respiratory symptoms related to the workplace and occupational disability from the European Community Respiratory Health Survey (ECRHS). METHODS:Th...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Blanc PD,Burney P,Janson C,Torén K

    更新日期:2003-09-01 00:00:00

  • Stump neuroma masquerading as recurrent malignancy on chest roentgenogram.

    abstract::An amputation neuroma is a nerve's attempt at repair following amputation. While many are asymptomatic, some present as a painful mass. We describe a patient who, following a forequarter amputation for sarcoma, developed a stump neuroma that was unusual because it was first discovered on a routine chest roentgenogram....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.3.684

    authors: Donnal JF,Coblentz CL,Bergin CJ

    更新日期:1989-03-01 00:00:00

  • Brief questionnaires for patient-reported outcomes in asthma: validation and usefulness in a primary care setting.

    abstract:UNLABELLED:STUDY OBJECTIVES AND DESIGN: Health-related quality of life (QoL) instruments are generally used for studies of asthma in specialized settings. For primary care use, there is a need for brief and simple questionnaires for structured patient-reported outcomes. We validated the Mini-Asthma Quality of Life Ques...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.129.4.925

    authors: Ehrs PO,Nokela M,Ställberg B,Hjemdahl P,Wikström Jonsson E

    更新日期:2006-04-01 00:00:00

  • Benefits of nocturnal nasal CPAP in patients with cystic fibrosis.

    abstract::Patients with cystic fibrosis (CF) often hypoventilate during sleep with marked falls in oxygen saturation (SaO2%). This occurs most commonly during REM sleep, when there is a reduction in rib cage excursion and a fall in end-expiratory lung volume (EELV). The aim of this study was to examine the effect of nocturnal n...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.6.1717

    authors: Regnis JA,Piper AJ,Henke KG,Parker S,Bye PT,Sullivan CE

    更新日期:1994-12-01 00:00:00