Abstract:
:Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously administered (inhaled) nitric oxide can mediate pulmonary vasodilatation and improve pulmonary function in some patients with lung injury, treatment of lung allograft recipients with inhaled nitric oxide may ameliorate ischemia-reperfusion injury, thereby improving perioperative pulmonary function and diminishing ventilatory support requirements. This review examines the biology of nitric oxide and present data that support its potential therapeutic effects for lung transplant recipients.
journal_name
Chestjournal_title
Chestauthors
Meyer KC,Love RB,Zimmerman JJdoi
10.1378/chest.113.5.1360subject
Has Abstractpub_date
1998-05-01 00:00:00pages
1360-71issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)47551-8journal_volume
113pub_type
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