The therapeutic potential of nitric oxide in lung transplantation.

Abstract:

:Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously administered (inhaled) nitric oxide can mediate pulmonary vasodilatation and improve pulmonary function in some patients with lung injury, treatment of lung allograft recipients with inhaled nitric oxide may ameliorate ischemia-reperfusion injury, thereby improving perioperative pulmonary function and diminishing ventilatory support requirements. This review examines the biology of nitric oxide and present data that support its potential therapeutic effects for lung transplant recipients.

journal_name

Chest

journal_title

Chest

authors

Meyer KC,Love RB,Zimmerman JJ

doi

10.1378/chest.113.5.1360

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

1360-71

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)47551-8

journal_volume

113

pub_type

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