Characterization of the clonidine receptor site.

Abstract:

:At the cardiac sympathetic nerve terminal the alpha 2-adrenoceptor is presynaptic and appears to be located at an extrasynaptic site. This is suggested by (1) absence of evidence of autoinhibitory feedback at physiologic stimulus levels up to about 50 percent of the maximum chronotropic response in the isolated guinea pig right atrium, and (2) absence of significant competition between clonidine and synaptically released noradrenaline (NA) for the presynaptic site. In the central nervous system (CNS) cardiovascular alpha 2-receptors are probably located at a postsynaptic site in bulbospinal regions of the brain, since they produce effects identical to those of synaptic release of NA. Experiments with the clonidine analog alinidine (ST 567) suggest that there are differences in central receptor type subserving clonidine-mediated baroreflex heart rate and blood pressure changes.

journal_name

Chest

journal_title

Chest

authors

Korner PI,Angus JA,Lew MJ,Heinzow BG

doi

10.1378/chest.83.2_supplement.345

subject

Has Abstract

pub_date

1983-02-01 00:00:00

pages

345-9

issue

2 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)40030-3

journal_volume

83

pub_type

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