Abstract:
:At the cardiac sympathetic nerve terminal the alpha 2-adrenoceptor is presynaptic and appears to be located at an extrasynaptic site. This is suggested by (1) absence of evidence of autoinhibitory feedback at physiologic stimulus levels up to about 50 percent of the maximum chronotropic response in the isolated guinea pig right atrium, and (2) absence of significant competition between clonidine and synaptically released noradrenaline (NA) for the presynaptic site. In the central nervous system (CNS) cardiovascular alpha 2-receptors are probably located at a postsynaptic site in bulbospinal regions of the brain, since they produce effects identical to those of synaptic release of NA. Experiments with the clonidine analog alinidine (ST 567) suggest that there are differences in central receptor type subserving clonidine-mediated baroreflex heart rate and blood pressure changes.
journal_name
Chestjournal_title
Chestauthors
Korner PI,Angus JA,Lew MJ,Heinzow BGdoi
10.1378/chest.83.2_supplement.345subject
Has Abstractpub_date
1983-02-01 00:00:00pages
345-9issue
2 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(15)40030-3journal_volume
83pub_type
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